HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE

D. Gareeva; N. Zagidullin; I. Lakman; R. Islamova; Sh. Zagidullin

doi:10.15829/1560-4071-2016-4-eng-190-194

HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE

D. Gareeva, N. Zagidullin, I. Lakman, R. Islamova, Sh. Zagidullin

https://doi.org/10.15829/1560-4071-2016-4-eng-190-194

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Abstract

Pathological heart rate turbulence (HRT) after premature ventricular complexes (PVCs) in patients with coronary heart disease (CHD) and myocardial infarction (MI) may predict higher mortality rate. Aim. To estimate the predictive power HRT in 5 year observational study in patients with CHD. Material and methods. 173 patients with CHD and in whom HRT was possible to record, were analyzed from 2010-2011 until 2015 with survival rate and turbulence slope (TS) and turbulence onset (TO) estimation. Results. Pathological TO showed no correlation with survival rate (p>0,05) but pathological TS in 5 years period (p=0,00026) correlated with survival rate with post-MI patients. Moreover, it had a predictive power also with non-MI patients (p=0,0032). The survival (Kaplan-Mayer) curves between normal and pathological TS started to divide from the 36 months of observation. Presence of nTS in post MI patients increased mortality rate in 5,14 times (p=0,00002) and in non-MI — in 4,99 times (p=0,00002). Conclusions. HRT slope parameter showed to be highly effective in mortality risk prediction in patients with CHD.

Keywords

heart turbulence rate, total mortality, myocardial infarction

About the Authors

D. Gareeva

Bashkir State Medical University
Russian Federation

clinical resident of Department of Internal Medicine;

assistant in Cardiology Department, city hospital N21,

450000, Ufa, Lenin str, 3

N. Zagidullin

Bashkir State Medical University
Ufa

I. Lakman

Ufa State Aviation Technical University
Ufa

R. Islamova

Ufa State Aviation Technical University
Ufa

Sh. Zagidullin

Bashkir State Medical University
Ufa

References

1. Moss AJ, Hall WJ, Cannom DS, et al. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. N Engl J Med. 2006;335:1933-40.

2. Lanza GA, Sgueglia GA, Angeloni G, et al. Prognostic value of heart rate turbulence and its relation to inflammation in patients with unstable angina pectoris. Am J Cardiol. 2009;15:103(8):1066-72.

3. Bauer A, Malik M, Schmidt G, et al. Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: International Society for Holter and Noninvasive Electrophysiology Consensus. J Am Coll Cardiol. 2008; 52: 1353-65.

4. Bauer A, Malik M, Barthel P, et al. Turbulence dynamics: an independent predictor of late mortality after acute myocardial infarction. Int J Cardiol. 2006;107:42-7.

5. Tsvetnikova AA, Yuarngart ER, Parmon EV, et al. Heart rate turbulence: methodological aspects. — AS Saint-Petersburg: INKART 2008, 32c.

6. Gareeva DF, Zagidullin BI, Nagaev IA, et al. Heart rate turbulence as a predictor of the risk of cardiovascular death. Practical medicine. 2012; 6: 39-43.

7. Zuern CS, Barthel P, Bauer A. Heart rate turbulence as risk-predictor after myocardial infarction. Front Physiol. 2011 Dec 12;2:99. doi:10.3389/fphys.2011.00099. eCollection 2011. PubMed PMID: 22180744; PubMed Central PMCID: PMC3238051.

8. Barthel P, Schneider R, Bauer A, et al. Risk stratification after acute myocardial infarction by heart rate turbulence. Circulation. 2003;108:1221-6.

9. Exner DV, Kavanagh KM, Slawnych MP, et al., on behalf of REFINE Investigators. Noninvasive risk assessment early after a myocardial infarction the REFINE study. J Am CollCardiol. 2007;50:2275-84.

10. Stein PK, Deedwania P. Usefulness of abnormal heart rate turbulence to predict cardiovascular mortality in high-risk patients with acute myocardial infarction and left ventricular dysfunction (from the EPHESUS study). Am J Cardiol. 2009;103:1495–1499.

11. Sestito A, Valsecchi S, Infusino F, et al. Differences in heart rate turbulence between patients with coronary artery disease and patients with ventricular arrhythmias but structurally normal hearts. Am J Cardiol. 2004;93:1114–8.

12. Bauer A, Barthel P, Schneider R. et al. Improved stratification of autonomic regulation for risk prediction in post-infarction patients with preserved left ventricular function (ISARRisk). Eur Heart J. 2009;30:576-83.

13. Bauer A, Kantelhardt JW, Barthel P. et al. (2006а). Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study. Lancet. 2006;367:1674-81.

Supplementary files

	1. HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE
	Subject	Heart turbulence rate; total mortality; myocardial infarction.
	Type	Материалы исследования
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	2. Гареева Д.Ф. Таблица 1
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Review

For citations:

Gareeva D., Zagidullin N., Lakman I., Islamova R., Zagidullin Sh. HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE. Russian Journal of Cardiology. 2016;(4-eng):190-194. https://doi.org/10.15829/1560-4071-2016-4-eng-190-194

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)

	Title	HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE
	Creator (or owner) of file	Gareeva Diana
	Subject	Heart turbulence rate; total mortality; myocardial infarction.
	Type	Материалы исследования
Brief description	Pathological heart rate turbulence (HRT) after premature ventricular complexes(PVCs) in patients with coronary heart disease (CHD) and myocardial infarction (MI) may predict higher mortality rate. Aim. To estimate the predictive power HRT in 5 year observational study in patients with CHD. Methods.173 patients with CHD and in whom HRT was possible to record, were analyzed from 2010-2011 until 2015 with survival rate and turbulence slope (TS) and turbulence onset (TO) estimation. Results. Pathological TO showed no correlation with survival rate (p>0.05) but pathological TS in 5 years period (p=0.00026) correlated with survival rate with post-MI patients. Moreover, it had a predictive power also with non-MI patients (p=0.0032). The survival (Kaplan-Mayer) curves between normal and pathological TS started to divide from the 36 months of observation (Fig. 1). Presence of nTS in post MI patients increased mortality rate in 5.14 times (p=0.00002) and in non-MI – in 4.99 times (p=0.00002). Conclusions. The pathological heart rate turbulence slope parameter showed to be highly effective in mortality risk prediction in patients with coronary heart disease. Key words. Heart turbulence rate, total mortality, myocardial infarction.
	Date	2016-01-29
Language	en

	Title	Гареева Д.Ф. Таблица 2
	Date	2016-01-31

	Title	Гареева Д.Ф. Таблица 3
	Date	2016-01-31

	Title	Гареева Д.Ф. Таблица 4
	Date	2016-01-31

	Title	Гареева Д.Ф. Таблица 5
	Date	2016-01-31

	Title	Гареева Д.Ф. Таблица 1
	Type	Анализ данных
	Date	2016-01-31

	Title	Гареева Д.Ф.Название рисунков
	Date	2016-01-31

	Title	ГарееваДФ.Список авторов
	Date	2016-01-31

	Title	ГарееваДФ.Список сокращений
	Date	2016-01-31

	Title	ГарееваДФ.Списоклитературы
	Date	2016-01-31

	Title	ГарееваДФ.Текст статьи
	Date	2016-01-31

	Title	ГарееваДФ.Титульный лист
	Date	2016-01-31

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Russian Journal of Cardiology

HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE

Full Text:

Abstract

Keywords

About the Authors

References

Supplementary files

Review

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