FIRST RUSSIA-BASED STUDY OF POLYMORPHISM rs2200733 CHROMOSOME 4q25 ASSOCIATION WITH DEVELOPMENT OF THE LONE ATRIAL FIBRILLATION

V. A. Shulman; S. Yu. Nikulina; N. V. Aksyutina N; E. E. Poplavskaya; B. V. Nazarov; V. N. Maksimov

doi:10.15829/1560-4071-2016-10-28-31

FIRST RUSSIA-BASED STUDY OF POLYMORPHISM rs2200733 CHROMOSOME 4q25 ASSOCIATION WITH DEVELOPMENT OF THE LONE ATRIAL FIBRILLATION

V. A. Shulman, S. Yu. Nikulina, N. V. Aksyutina N, E. E. Poplavskaya, B. V. Nazarov, V. N. Maksimov

https://doi.org/10.15829/1560-4071-2016-10-28-31

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Abstract

Atrial fibrillation (AF) is one of the most prevalent tachiarrhythmias, with at date non fully understood etiology. Recently, the attention is paid to genetic determinants of AF.

Aim. To assess the role of rs2200733 polymorhpism on the chromosome 4q25 in development of AF in Russian population.

Material and methods. Totally, 76 patients studied with AF, and control group, number 73 persons without cardiovascular pathology. All participants underwent laboratory and genetic investigations.

Results. A statistically significant prevalence of genotype ТТ is found (21,21% vs 4,11%, р=0,015) and allele Т (34,85% vs 19,86%, р=0,03) in the group of patients with the lone AF comparing to the controls. Therefore, TT genotype and T allele of rs2200733 chromosome 4q25 could be predictors of unknown origin AF development.

Keywords

atrial fibrillation, chromosome 4q25, rs2200733

About the Authors

V. A. Shulman

V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation

S. Yu. Nikulina

V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation

N. V. Aksyutina N

V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation

E. E. Poplavskaya

V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation

B. V. Nazarov

V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk

V. N. Maksimov

Scientific-Research Institute of Therapy and Prevention, Novosibirsk, Russia
Russian Federation

References

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Review

For citations:

Shulman V.A., Nikulina S.Yu., Aksyutina N N.V., Poplavskaya E.E., Nazarov B.V., Maksimov V.N. FIRST RUSSIA-BASED STUDY OF POLYMORPHISM rs2200733 CHROMOSOME 4q25 ASSOCIATION WITH DEVELOPMENT OF THE LONE ATRIAL FIBRILLATION. Russian Journal of Cardiology. 2016;(10):28-31. (In Russ.) https://doi.org/10.15829/1560-4071-2016-10-28-31

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)

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	Title	Сопроводительное письмо
	Date	2016-06-06

	Title	титульный лист
	Date	2016-06-28

	Title	Рисунок1
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок2
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок3
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок4
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок5
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок6
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок7
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Рисунок8
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Конфликт
	Type	Исследовательские инструменты
	Date	2016-06-06

	Title	Этика
	Type	Исследовательские инструменты
	Date	2016-06-06

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Russian Journal of Cardiology

FIRST RUSSIA-BASED STUDY OF POLYMORPHISM rs2200733 CHROMOSOME 4q25 ASSOCIATION WITH DEVELOPMENT OF THE LONE ATRIAL FIBRILLATION

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Abstract

Keywords

About the Authors

References

Supplementary files

Review

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