Parameters of lipid transport system as well as that of haemostasis have been studied in coronary heart disease (CHD) patients (n = 70) having at least one of two major CHD risk factors - arterial hypertension (AH) and dyslipoproteinemia (DLP). Patients with combination of AH and DLP significantly differed from those with isolated DLP by higher levels of total and low density lipoprotein cholesterol, triglycerides and apolipoprotein B. As compared with patients with isolated AH they differed by elevated systolic and diastolic blood pressure. The increased blood thrombogenicity (combination of disturbances in haemostasis resulted in enhanced thrombosis) was high both in hypertensive and dyslipidemic subjects. However, while in group with isolated DLP there was a predominance of decreased anticoagulation and fibrinolysis, in patients with isolated AH the major impact was related to elevated platelet aggregation. Thus, unfavorable shifts in lipoprotein and haemostasis parameters found in patients with AH and DLP could be regarded as markers of their atherothrombogenicity.

According to standard ECG and daily ECG monitoring, myocardium repolarization processes and heart rate variability in patients with Coronary Heart Disease (CHD) combined with gastroesophageal reflux disease (GERD) have been studied.

Patients with combined pathology have higher duration and asynchrony of myocardium repolarization processes (average QT duration and dispersion) have been found compared to patients with isolated CHD and GERD. A combination of GERDE and CHD is associated higher heart rate rigidity compared to CHD alone. The results confirm the "complicating" significance of GERD in CHD.

Patients surviving non-ST-segment-elevation acute coronary syndrome constitute a group of high coronary risk and sudden death risk and are therefore in particular need of adequate and proper rehabilitation and secondary prevention including physical training. 122 patients surviving non-Q-wave myocardial infarction or an episode of unstable angina have been studied, with mild to moderate arterial hypertension (mean age 52. 26± 0. 56 years), in the period of stabilization 3-8 weeks following the onset of the acute period. The main group (80 subjects) underwent controlled systematic physical training of moderate intensity for 3 months, leading to improved central hemodynamical parameters, left ventricle diastolic function, increased tolerance to physical stress, promoting blood pressure decrease, which, in overall, improved the clinical course of the disease and led to early restoration of working capacity, decreased invalidation, decreased the risk of cardiovascular complications.

Detailed echocardiographic study of 85 patients with various forms of syphilis (secondary, of skin and mucous membranes, early occult and seroresistant) has revealed disorders of left ventricle diastolic function in 93. 4 %. They manifested as accelerated transmitral blood flow in early diastole and a tendency to its decrease during atrial systole, decreased systolic and increased diastolic antegrade flows in pulmonary veins. Disorders of heart diastolic function were combined with evidence of increased left ventricle end diastolic pressure.

Evaluation to determine the relationship between coronary reserve and myocardium diastolic function was performed in 58 patients surviving a Q-wave myocardial infarction an average of 2. 4 months ago. All patients underwent a hyperventilation test and transesophageal cardiac pacing (TECP) with simultaneous registration chest reogram, determination of left ventricle end diastolic pressure (EDP) and evaluation of diastole duration. On TECP 2 variants of ST depression changes have been detected: wave-like and progressively deepening. Temporary decrease of ST depression was associated with prolonged diastole and decreased EDP / IN the second case shortened diastole was revealed along with EDP increased more than twofold. Therefore heterogeneity of patients following MI has been shown, with vaspospastic reactions possible to reproduce in a part of those patients, associated with altered IV diastolic filling and a phenomenon of intermittent myocardium ischemia.

Whereas evolution changes of central hemodynamics in healthy subjects and patients with arterial hypertension (AH) at various ages, literature lacks data on aging changes of hemodynamics in capacity vessels. The issue of possible influence of functional changes in the venous system on the development of postural hypotension in hypertensive subjects of various age groups is also studied insufficiently. 140 patients with moderate arterial hypertension aged 17 to 50 have been studied. Main values of central hemodynamics and peripheral venous blood Suppl.y at baseline and following an active postural test have been analyzed. The results of the study suggest progressing of venous hypertension patterns in AH patients with age and decrease of adequate vascular Suppl.y on the part of capacity vessels during a postural test.

The previouse experimental studies revealed that mezenchimal bone marrow stem cells (MSC) have the ability of differentiating into cardiomiocytes in vitro and in vivo inducting angiogenesis and restoring the impared myocardial function. At that, the cell technology capacities in clinical cardiology remain unstudied.

Starting from January 2003 8 patients suffering from heart failure underwent the transplantation of autological MSC with different stages of cultivation: MSC was administered intracoronary to 6 and intramuraly to the post-infarction cardiosclerosis zone.

 In three cases the MSC were marked with thallium-20 Idirectly before transplantation in order to define the location of MSC during the hours after transplantation. The results of radionuclide scintigraphy demonstrated that in 1, 5 hours after intracoronary administration and in 6, 5 hours after intramyocardial injection MSC remain in the zone of administration. In 1 month after the transplantation the improvement of regional perfusion and diastolic function was observed in old patients. Significant growth of functional ischemia of the left ventricle from 31 to 40 % was observed in patient suffering from ИКМП after intramural administration of MSC. In 1 month after MSC transplantation quality of life and phisical stress tolerance improvement was observed. Intracoronary administered MSC remain in coronary artery, through which MSC was administered. Intracoronary and intramural administration of MSC improves functional indices of retractive myocardial function, increases physical stress tolerance and life quality of patients suffering from chronic heart failure.

The influence of calcium antagonists and β-blockers on platelet function and rheological blood characteristics in patients with ischemic blood disease.

The efficacy of the new drug form of nifedipine with prolonged action - Nifecard-XL in treatment of arterial hypertension.

The influence of cardioselective β1-blocker Nebivolol on external respiration function in patients with ischemic heart disease accompanied by chronic obstructive bronchitis was studied. 39 patients randomized on 2 groups were examined. The basic group (n = 20) took nebivolol in daily dose 5 mg, the control group (n = 19) took placebo. The duration of therapy was 30 days. External respiration function was investigated by spirographic method on "Spirograph SP 01 "K" before and after the treatment. The following indicator were observed: lung vital capacity (LVC), forced LVC (FLVC), forced expiratory volume (FEV1), Tiffno index (FEV1 / FLVC), maximal free pulmonary breathing capacity (FPBC), peak expiratory flow rate (PEFR) 25 % LVC (PFR 25 % - patency of large bronchus), PFR 50 % (patency of mean bronchus) PFR 75 % (patency of small bronchus). Initially all patients had trachea-bronchial permeability abnormalities. There was evident antianginal action in time of nebivolol therapy. Impairment of external respiration function rates was not been observed.

In aim to study efficacy and safety of propafenone (Propanorm), open prospective поп randomized study in-patients with paroxysmal form of auricular fibrillation (AF) was carried out. 31 patients - 16 men (51,6 % ) and 15 women (48,4 % ) with mean age 58, 1± 8 years were included in the study. The paroxysmal form AF was observed in 29 patients (93,5 % ), persistent form - in 2 patients (6,5 % ). The reason of arrhythmia in 21 patients (67,7 % ) was ischemic heart disease, in 12 patients (38,7 % >) - arterial hypertension, in 2 patients (6,4 % ) - rheumatic heart diseases, in 1 patient (3,2 % ) - idiopathic AF. The medication for rapid relief of symptoms of paroxysmal auricular fibrillation was administered in single stress dose 600 mg per os. Propanorm restored the rhythm in 74,2 % > patients. The disorder of intraventricular conduction on EKG became evi-dentin 7 patients (22,5 % ) in time from 2to 16. 5 hours (on average 5, 1 hour), atrioventricular heart block of I stage - in 2 patients (6,45 % ), aberrant ventricular complex - in 2 patients (6,45 % ), pacemaker migration and sinus bradycardia - in 1 patient (3,2 % ). This disorders eliminated independently without special intervention. Extracardiac side effects during single intake were not observed. Propafenone appeared to be high-performed antiarrhythmic medication in rapid relief of symptoms of paroxysmal auricular fibrillation. Its application is possible in the outpatient setting.

In a randomized open crossover study clinic equivalence of two drug forms of enalapril (Renitec®and Епат® in patients with arterial hypertension (AH) was compared. 46 patients with mild to moderate AH (mean age 57, 0 ± 12, 5years) have been studied. All underwent courses of treatment with Renitec® and Enam® 4 weeks each. Every drug's initial daily dose was 10 mg and increased to 20 mg daily in case of insufficient antihypertensive effect. The effect of treatment was evaluated by daily BP dynamics. After 4 weeks therapy Enam® and Renitec® resulted in reliable indices reduction both systolic BP (SBP) and diastolic BP (DBP). At the end of a course of treatment with Enam® SBP decreased to 16, 8 mm Hg, DBP to 8, 2 mm Hg (in both cases p < 0,001). Under the influence of Renitec® SBP decreased to 19, 1 mm Hg, DBP to 9, 6 mm Hg (in both cases the tendency to more marked effect of Renitec® was noted, but differences between two medications were not statistically significant. During the course of both medications insignificant inauthentic increase of HR was observed. The dose-effect analysis showed that for achieving the equal level of SBP reduction the dose of Enam® should be slightly higher, at the same time the cost of therapy with much as Renitec® BP reduction was less in treatmentwith Enam®, then with Renitec®. Two drugforms of enalapril Enam® and Renitec® are clinically equivalent, at the same time the daily therapy of AH in treatment with Enam® prove to be significantly inexpensive.

The article deals with the study of influence of autovenous ultraviolet irradiation of blood (AUIB) in monotherapy and in combination with acetylsalicylic acid on hemostasis state in patients on out-patients rehabilitation stage after myocardial infarction. 26 men were included in the study. 16 patients of the first group were underwent by 5 procedures of AUIB; 10 patients of second group combined A UIB with acetylsalicylic acid intake 250 mg daily. As the most strongly pronounced effect of AUIB was blood fibrinolytic system activation. The significant increase of soluble fibrin-monomer complex (SFMC) level was revealed that by indirection could testify to pro-thrombotic effect of method. Combined therapy by AUIB and acetylsalicylic acid resulted in increase of antiaggregant action and reduce the number of SFMC.

The dynamics of alterations some parameters of right ventricle in patients with untreated idiopathic scoliosis and after surgical treatment.

The aim of the study was to assess the influence of intravenous administration of mexicor (7mg / kg) on electrophysiological, hemodynamic action and antiarrhythmic activity of nibentan (1 mg / kg), propranolol (1,4mg / kg) and verapamil (0,4mg / kg) in acute myocardial ischemia in experimental study. The cats were examined. Changes in automatism of sinus node, conductivity and myocardial reflex excitability were estimated. Levels of intraventricular and arterial pressure were determined, antiarrhythmic activity was analyzed. Preventive use of mexicor in combination with antiarrhythmic drugs in acute occlusion of coronary artery has not been followed by their influence abatement on electrophysiological parametres of heart. The tendency to enhancement of membrane-stabilizing action of studied medications by antioxidant was observed. Mexicor not only relief antiarrhythmic activity of nibentan and propranolol and enhance protective activity of verapamil in occlusive arrhythmias, but as antioxidant reduces cardiodepressive and hypertension effect of antiarrhythmic drugs in acute occlusion of coronary artery.

Possible ways to increase effectiveness of reperfusion therapy.

Latent myocardial ischemia: relation between proved and unproved.

In study on a basement of our own research and literature data clinical course of virus myopericarditis was analyzed. Special consideration has been given to characteristics of electrocardiographic indicators, four stages of evolution of cardiographic indicators of illness were emphasized. Increase of hemorrhagic myopericarditis frequency, evidently with virus nature, was noted. Recomendations for treatment in patients suffering from myopericarditis with positive prognosis were given. At the same time, prognosis of diffuse myocarditis remains negative, and indications for its rational treatment determined insufficiently.