The influence of clinically apparent thyroid dysfunction on cardiovascular system is indisputable. However, until now there is no clarity weather hypothyroidism, particularly its subclinical form, influences the coronary heart disease (CRT)) course. 102 patients with CRT) who have no thyroid dysfunction and who have nontoxic colloid nodular goiter were included in the present study. Subclinical decrease of thyroid function was revealed in 24 patients (23 % of events). Used methods included 24-hour electrocardiography and blood pressure (BP) monitoring, determination of plasma thyroid hormones and thyrotropin, ultrasound imaging of thyroid gland. The results showed that all groups of patients with CRD independently of thyroid function have a silent myocardial ischemia prevailed over painful myocardial ischemia as in frequency and as in duration. Diastolic BP and heart rate meanings were in a reverse dependence on thyroid hormone plasma levels that was more evidential in patients with subclinical thyroid dysfunction.

There were showed that young and middle-aged women suffering from coronary artery disease (CAD) have metabolic disturbances including hypercholesterolemia in 44,8 %, hypo-alfa-cholesterolemia in 16,8 %, hypertriglyceridemia in 76,7 %, glucose intolerance in 8 % and diabetes mellitus in 5,4 % of events. 79 % of patients have excess of body weight and «androgenous» type of obesity. Hypertensive women with normal body weight have hyperinsilinemia confirmed by C-peptide meanings at 3-min and 60-min intervals of glucose tolerance test. Basal hyperinsulinemia (13 mkU. /mL) directly correlated to body mass index and waist circumference that confirmed the presence of insulin resistance in examined women.

There was research about the ages differences in blood pressure dynamics, renin-aldosteron system state and lipid profile in patients with arterial hypertension and thyreotoxicosis. It was find, that the old patients have arterial hypertension 2 degree. It was high value of an index time of hypertension, variability, the mornings rise and speed of systolic blood pressure about blood pressure monitoring. These all means a high risk of cardio-vascular complications. The old patients renin and aldosteron concentrations are normal and low. The thyreotoxicosis young and old patients blood Cortisol concentration are normal and have not different of arterial hypertension degrees. Its no dependents from patients ages. The difference character of blood lipid specter of old patients cholesterol and triglycerides are high.

Neurohumoral aspects of formation of cor pulmonale in chronic obstructive pulmonary diseases.

The aim of the study - to observe distant clinical effectiveness of balloon coronary angioplasty (BCA) in patients with double-vascular affection of bloodstream depending on completeness of myocardial revascularization. 69 patients with ischemic heart disease and with initially clinically successful performed double-vascular affection of bloodstream were included in the study. Preservation of achieved clinical success in time from 6 to 12 months after performed BCA as initial clinical success was kept in mind. Distant clinical effectiveness of BCA averaged 56,6 % (39 of 69 patients). The percentage of favourable clinical results in patients with achieved complete anatomical myocardial revascularization averaged 55,2 % (16 from 29 patients), with incomplete adequate functional anatomical revascularization averaged 54,8 % (17 from 31 patients), with incomplete anatomical revascularization (BCA of symptom connected artery (SCA)) averaged 66,7 % (6 from 9 patients). In overwhelming majority of cases restenosis of reconstruction segments was the reason of clinical condition impairment. During the stent implantation distant clinical results were slightly better independently of extent of achieved revascularization. Distant clinical results of BCA in patients with double-vascular affection of bloodstream straight depend on quantity of arteries subjected to angioplasty. Under one year observation the achievement of complete anatomical revascularization reduce the clinical effectiveness. In distant period stent implantation slightly improves clinical results of double-vascular BCA due to reduction of percentage of restenosis. Incomplete anatomical revascularization improve clinical results of BCA at impairment of two coronary arteries, therefore during selection of surgical intervention capacity is more advisable to prefer BCA.

The influence of ACE inhibitor enalapril therapy on functional activity of blood cells and vasomotor function of endothelium in patients with essential hypertension (EH) was studied. 21 patients with EH II stage and 17 almost healthy persons (all males) were included. Ultrasound of heart, radial and carotid arteries, spontaneous platelet and erythrocyte aggregation, erythrocyte deformity and leukocyte activity were assessed. The second examination of patients with EH was carried out in 12 weeks following enalapril treatment with 10-40 mg a day. Baseline increase of spontaneous platelet and erythrocyte aggregation, erythrocyte hardness and leukocyte activity were revealed in patients with EH. Antihypertensive effect of enalapril was in 15 patients (71 %). Hemoreology improvement and decrease of leukocyte activity were accompanied by increase of volume flow velocity in radial artery while endothelium-dependent vasodilation was unchanged. Long-term enalapril therapy was accompanied by improvement of hemoreology, decrease of leukocyte activity and increase volume flow velocity in radial artery. Positive dynamics of functional states of blood cells did not depend on severity of antihypertensive effect of enalapril.

Dynamics of daily blood pressure rhythm and heart rate variability in patients with arterial hypertension during a new form of nifedipine (Nifecad XL) treatment.

The application of simvastatine in arterial hypertension patients with metabolic syndrom corrects dislipoproteidemia, peroxidation syndrome, thrombocyte formation and optimized the thrombocyte hemostasis. Simvastatine inhibits decreased adhesive and aggregative function of thrombocytes. For stabilization of the correction results of metabolic processes and thrombocyte hemostasis in arterial hypertension patients with metabolic syndrom the application of simvastatine should be prolonged. With the aim of the decrease of body mass and weakening of insulin resistance in arterial hypertension patients with metabolic syndrom to suppose the combination of simvastatine with inmedicamental threatment.

Characteristics of psychologic traumatizing events in patients with myocardial infarction with different stress levels and different types of behavior activity.

Prevalence of modifying risk factors and quality of its correction were studied in 150 patients with arterial hypertension II-III stage. Study revealed poor blood pressure control, high prevalence of risk factor and insufficient quality of its correction. The most frequent risk factor was dislipidemia in 41,3 % of patients. There were no patients with control of dislipidemia by statins.

Contemporary methods of bloodstream and visual fields investigation in patients with glaucoma.

Proarrhythmic activity study of a tertiary lidocaine derivative.

Arterial hypertension in pregnancy: mechanisms of formation, prevention and therapeutic approaches.

Treatment of paroxysmal atrial fibrillation.

Prevention and treatment of thrombosis and thromboembolias with oral anticoagulants.

Clinical and prognostic significance of nonthyroidal illnes syndrome in cardiovascular diseases.

Clinical course, prognosis and therapy of chronic heart failure in patients with normal systolic and diastolic left ventricle function.