Spectral and temporal parameters of heart rate variability in patients with severe alcohol intoxication were analyzed in short-time ECG recording, as well as during 24-hour ECG monitoring. Individuals with acute alcohol heart injury and ventricular arrhythmias had reduced heart rate variability, comparing with patients not demonstrating life-threatening ventricular arrhythmias. The most powerful predictors of heart rate variability disturbances were spectral parameters in brief ECG fragments, and temporal characteristics - in 24-hour ECG monitoring.

In volunteers of various age and with varying myocardial contractility, parameters of heart rate variability (HRV) were assessed during functional test with controlled breathing (frequency control) and bicycle stress test. HRV spectral components had different sensitivity to periodical breathing of varying frequencies, with maximal reaction to ft 1 Hz diapason and 10-second breathing period. Sensitivity level correlated with heart pathology's severity. During exercise test, density persistency of 0.1 Hz component capacity depended on myocardial contractility. Sensitivity and consistency parameters of generated 0.1 Hz component can be used in assessment of heart disease severity.

Echocardiography, Dopller sonography, and heart rate variability assessment were performed in 53 subjects. A system for quantitative analysis of organic heart pathology's severity, with calculation of integral echocardiography index, has been developed. Principles of functional status dynamics, in progression of organic heart pathology, have been proposed. Moderate correlation between heart rate variability parameters, integral echocardiography index, and age, was demonstrated.

Arterial hypertension (AH) severity in hypothyrosis and thyrotoxicosis was investigated in various age groups of patients. It was demonstrated that AH associated with thyroid dysfunction might have two ethiologic forms: endocrine (linked to thyroid dysfunction), and combined (AH in anamnesis, later combined with endocrine blood pressure increase). In hypothyrosis, AH was more severe than in hyperthyrosis, that could be explained by younger age of thyrotoxic patients. Among hypothyroid individuals, combined forms of AH were prevalent, with AH in anamnesis. That might be explained by more advanced age of hypothyroid patients, and their blood lipid profile abnormalities.

Atrial ectopic activity and atrial conduction in patients with paroxysmal atrial fibrillation (AF) and sick sinus syndrome (SSS) were investigated. Two groups of individuals with coronary heart disease (CHD) and AF paroxysms were examined: 105 participants with SSS, and 115 people with normal sinus function. According to the paroxysm length, three subgroups inside each group were formed: participants with short AF paroxysms (<30 s), prolonged paroxysms (>30 s), and combined ones. In all patients with short AF paroxysms, ectopic atrial activity was prevalent. People with prolonged AF paroxysms demonstrated decreased intra-atrial conduction and increased left atrium size. In the first group, short AF paroxysms were prevalent, prolonged paroxysms were typical for the second group. Authors suggest that it might be explained by activation of ectopic automatism centers in patients with SSS. According to five-year follow-up results, in SSS, paroxysms transformed into chronic AF significantly less often than in normal sinus function. Therefore, in patients with CHD and SSS, the leading arrhythmogenic mechanism is ectopic generation of atrial impulses, and in individuals with normal sinus function, it is reentry.

Blood lipid profile, lipid peroxidation, and plasma/red blood cell antioxidant activity were studied in 127 individuals with acute and chronic leukemia. All patients, regardless of leukemia morphology, demonstrated antiatherogenic changes in lipid profile, as well as activated lipid peroxidation and decreased antioxidant reserve. These disturbances can be explained by anemia severity and diminished absolute numbers of functionally active, lipid-producing white blood cells. At autopsy, macroscopic examination of aorta and coronary artery tissue (47 cases of leukemia and 23 cases of other cancers), demonstrated significantly less manifested aortic and coronary atherosclerosis in leukemia, comparing to lung or gastro-intestinal cancers.

The aim of the study was to compare efficacy and safety of a new, prolonged-action nifedipine form - nifecard-XL, and standard nifedipine tablets, in arterial hypertension (AH). One hundred forty-seven individuals with mild to moderate AH (61 males, 86 females), aged 21-81, were included. In a randomized, cross-over study, patients were consecutively administered nifecard-XL (30 mg once a day), or corinfar (10 mg 3 times a day), for one month each. In non-responders, the dose was doubled after 2 weeks. Before 1st and 2nd course, there were control one-week periods, with all antihypertensives withdrawn. Efficacy was assessed during blood pressure (BP) office measurements and 24-hour BP monitoring. Total number of persons who completed the trial was 127. Nifecard-XL (30 mg per day) was effective in 108 articipants, and in another 29 daily dose of 60 mg was needed. Corinfar (30 mg a day) was effective in 93 patients, and another 41 individuals had to be administered 60 mg. Mean daily dose for nifecard-XL was 36.4+12.3 mg, for corinfar - 39.2+13.9 mg. According to office BP levels, nifecard-XL significantly better lowered systolic BP than corinfar. Both agents were equal in reducing diastolic BP. During 24-hour BP monitoring, nifecard-XL and corinfar significantly decreased systolic, diastolic, and mean BP, temporal indexes of systolic and diastolic BP, without any substantial differences between both agents. Adverse events were typical for this class of antihypertensives, with 33 events registered in corinfar group, and 16 - in nifecard-XL group.

The aim of the study was to assess in a double-blind, cross-over randomized trial the therapeutic equivalence of two amplodipine preparations (Cardilopin® and Norvasc®) in patients with arterial hypertension (AH). Thirty individuals with mild to moderate AH (mean age 61,2+1,7) were examined. All participants were treated with Cardilopin® and Norvasc® in six-week courses; the course consequence was randomized. The initial daily dose of amlodipine was 5 mg, in non-responders it was increased to 10 mg 2 weeks later. Treatment efficacy was assessed by rest blood pressure (BP) dynamics. Patients started the treatment with Norvasc® or Cardilopin® did not differ by main clinical characteristics. During Cardilopin treatment, systolic BP (SBP) lowered from 155,7+2,1 mm Hg to 138,8 ±1,5 mm Hg (p<0,001), diastolic BP (DBP) decreased from 95,4±l,2 mm Hg to 87,l±l,5mm Hg(p<0,001). Heart rate (HR) slightly increased -from 74,1±1,7 beats per minute (bpm) to 77,8±2,2 (non-significant). During Norvasc® treatment, SBP lowered from 156,3+2,1 mm Hg to 135,3 ±2,0 mm Hg (p<0,001), and DBP-from 95,2+1,5 mm Hgto 84,6+1,0 mm Hg (p<0,001). HR increased from 74,0+1,6 79,1+1,7 bpm (p<0,05). Authors conclude that Cardilopin® is equal to the «gold standard» amlodipine preparation, Norvasc®, by main clinical characteristics, and both medications are therapeutically equivalent to each other.

To assess influence of the natural fat tissue levels of lipophylic antioxidants and polyunsaturated fatty acids (PUFA) in patients with acute myocardial infarction (MI), on coronary heart disease (CRD) progression. Sixty patients, who had MI in 1991-92, were surveyed and included into the main group of EURAMIC study. According to the variants of CHD progression (death, recurrent MI, stroke, myocardial revascularization), all participants were divided into two groups: 25 individuals without CHD progression (Pr-), and another 35 - with CHD progression (Pr+). To study complex influence of traditional CVD risk factors, lipophylic antioxidants and PUFA levels on the long-term prognosis, as well as for assessing the individual input of each variable, multiple regression analysis was used. The results obtained have demonstrated the following: 1. Carotinoid and PUFA levels in fat tissue of acute MI patients did influence the long-term prognosis of CHD. 2. In patients with MI, decreased level of low-density lipoprotein cholesterol was a significant predictor of poor prognosis. 3. In initially normostenic MI patients, further increase in body mass index associated with worse CHD prognosis.

To study educational programs' dynamic influence on clinical symptoms and modifiable cardiovascular risk factors in patients with essential hypertension (EH), the results of the Kyrgyz Hypertensive Patient Club activity were analyzed. At baseline and during the next two years of follow-up, authors assessed disease awareness level, treatment compliance and consistency, blood pressure self-control skills, risk factors dynamics, and end-point incidence in 320 Bishkek patients with EH. Due to the educational program, awareness level had risen, and risk factor prevalence had decreased, with parallel improving in clinical symptoms.

The study involved 134 patients with coronary heart disease (CHD), aged 28-63, including 115 individuals with stable angina (functional class II), and 19 - with myocardial infarction in anamnesis. All patients underwent apex cardiography (ACG) with nitroglycerin during pain episode-free period. In patients with coronary occlusion, nitroglycerin-induced ACG dynamics was manifested only in поп-significantly diminished systolic wave asynergia, and decreased atrial complex amplitude. Patients without coronary occlusion demonstrated complete normalization of ACG. In all cases, with nitroglycerine effect reducing and, at last, disappearing, ACG returned to its baseline shape, registered before nitroglycerine administration. ACG curve typical for consistent, chronic silent coronarospasm was registered, being a manifestation of silent myocardial ischemia.