THE ROLE OF INTERLEUKIN-6 GENE IN DEVELOPMENT OF IDIOPATHIC SICK SINUS SYNDROME
https://doi.org/10.15829/1560-4071-2016-10-32-36
Abstract
Aim. To study the association of polymorphisms rs1800795 of gene IL-6 with the development of sick sinus node syndrome (SSS).
Material and methods. Totally, 109 patients studied, with idiopathic SSS, and 59 of their healthy relatives of I, II, III grade of relation, and 173 controls. Patients from main group were selected to subgroups according to sex and clinical type of the disease. All patients underwent standard clinical and instrumental cardiological assessment and molecular-genetic test of DNA. Statistics was done with software “Statistica 7.0”.
Results. There was significant predominance of homozygous genotype of rare allele of the studied gene in controls (18,5%±3,0) comparing to idiopathic SSS patients (8,5%±3,1), p=0,039, and to subgroup of males with SSS (5,2%±8 among SSS males versus 30,8%±9,1 among controls, р=0,03). Also there was significant predominance of the widespread genotype IL-6 among males with compensated SSS variant (69,2%±12,8) comparing to the controls (23,1%±8,3, р=0,005).
Conclusion. Probably the homozygous genotype GG of gene IL-6 is protective against idiopathic SSS.
About the Authors
S. Yu. Nikulina
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Competing Interests: конфликт интересов не заявляется
Russian Federation
Competing Interests: конфликт интересов не заявляется
O. V. Marilovtseva
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Competing Interests: конфликт интересов не заявляется
Russian Federation
Competing Interests: конфликт интересов не заявляется
A. A. Chernova
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Competing Interests: конфликт интересов не заявляется
Russian Federation
Competing Interests: конфликт интересов не заявляется
S. S. Tretyakova
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Competing Interests: конфликт интересов не заявляется
Russian Federation
Competing Interests: конфликт интересов не заявляется
D. A. Nikulin
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Competing Interests: конфликт интересов не заявляется
Russian Federation
Competing Interests: конфликт интересов не заявляется
V. N. Maksimov
FSBI SRI of Therapy and Prevention Medicine of SD RAMS, Novosibirsk, Russia.
Russian Federation
Competing Interests: конфликт интересов не заявляется
Russian Federation
Competing Interests: конфликт интересов не заявляется
References
1. Wu G, Cheng M, Huang H, et al. A variant of IL6R is associated with the recurrence of atrial fibrillation after catheter ablation in a Chinese Han population. PLoS One 2014; 9(6): e99623.
2. Lin MH, Sinner F, Brody J A, et al. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm 2014; 11(3): 452-7.
3. Mahemuti A, Abudureheman K, Aihemaiti X, et al. Association of interleukin-6 and C-reactive protein genetic polymorphisms levels with venous thromboembolism. Chin. Med. J. (Engl) 2012; 125(22): 3997-4002.
4. Adamopoulos S, Kolokathis F, Gkouziouta A, et al. Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy. Cytokine. 2011; 54(1): 68-73.
5. Li L, Li E, Zhang LH, et al. IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease. Genet. Mol. Res. 2015; 14(3): 8451-7.
6. Li YY, Zhou CW, Xu J, et al. Interleukin-6 C-572G gene polymorphism and coronary artery disease in Asian: a meta-analysis of 2511 subjects. Int. J. Clin. Exp. Med. 2015; 8(6): 8995-9003.
7. Tong Z, Li Q, Zhang J, et al. Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population. J. Int. Med. Res. 2013; 41(4): 1049-56.
8. Chen Z, Qian Q, Tang C, et al. Association of two variants in the interleukin-6 receptor gene and premature coronary heart disease in a Chinese Han population. Mol. Biol. Rep. 2013; 40(2): 1021-6.
9. Fragoso JM, Zuñiga-Ramos J, Arellano-González M, et al. The T29C (rs1800470) polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with restenosis after coronary stenting in Mexican patients. Exp. Mol. Pathol. 2015; 98(1): 13-7.
10. Rizzello V, Liuzzo G, Trabetti E, et al. Role of the CD14 C(-260)T promoter polymorphism in determining the first clinical manifestation of coronary artery disease. J. Cardiovasc. Med. (Hagerstown). 2010; 11(1): 20-5.
11. Dietel B, Cicha I, Voskens CJ, et al. Decreased numbers of regulatory T cells are associated with human atherosclerotic lesion vulnerability and inversely correlate with infiltrated mature dendritic cells. Atherosclerosis 2013; 230(1): 92-9.
12. Latkovskis G, Licis N, Zabunova M, et al. Common haplotype of interleukin-6 gene is associated with chronic total occlusions of coronary arteries. Int. Angiol. 2012; 31(2): 116-24.
13. Zhao X, Du JQ, Xu DY, et al. Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome [Electronic resource]. Lipids Health Dis. 2013; 12. URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554480/.
14. Lima-Neto LG, Hirata RD, Luchessi AD, et al Chlamydophila pneumonia and increased TLR4 gene expression in leukocytes are associated with acute myocardial infarction. J. B iol. Regul. Homeost. Agents. 2014; 28(3): 449-60.
15. Kiliszek M, Burzynska B, Michalak M, et al. Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction. PLoS One. 2012; 7(11): e50054.
16. Ljungman P, Bellander T, Nyberg F, et al. DNA variants, plasma levels and variability of interleukin- 6 in myocardial infarction survivors: results from the AIRGENE study. Thromb. Res. 2009; 124(1): P. 57-64.
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For citations:
Nikulina S.Yu., Marilovtseva O.V., Chernova A.A., Tretyakova S.S., Nikulin D.A., Maksimov V.N. THE ROLE OF INTERLEUKIN-6 GENE IN DEVELOPMENT OF IDIOPATHIC SICK SINUS SYNDROME. Russian Journal of Cardiology. 2016;(10):32-36. (In Russ.) https://doi.org/10.15829/1560-4071-2016-10-32-36
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