A RESISTANCE TO LEPTIN IN DEVELOPMENT OF DIFFERENT OBESITY PHENOTYPES
https://doi.org/10.15829/1560-4071-2016-4-14-18
Abstract
The underlying process of visceral obesity (VO) is frequently the resistance to regulating action of leptin on the patients food related behavior. There is ongoing research on the role of soluble leptin receptors (SLR) in the leptin signal transmittance and leptin resistance development (LR).
Aim. To study the relation of leptin metabolism parameters with insulin resistance (IR) in men with various obesity phenotypes.
Material and methods. Totally, 110 males included of the age 44-67 y.o., with arterial hypertension, absence of atherosclerosis of any area signs, and diabetes. The participants were selected to two groups according to metabolic obesity phenotype by the value of epicardial fat thickness (EFT) and body mass index. In groups we assessed the levels of insulin, HOMA-IR, serum leptine (SL), SLR and free leptin index (FLI) calculated as SL/SLR, lipid profile including apoproteines A1 and B (ApoA1, ApoB). EFT was measured via echocardiography.
Results. It has been shown, that leptin metabolism disorders and LR might lead to metabolically stout phenotype (MSP) and its main complication — IR. The regression equation is formulated that links FLI with HOMA-IR.
Conclusion. Leptin metabolism disorder is related to the development of VO and IR. FLI can be used as laboratory marker of LR, as an early marker of IR risk and, possibly, further cardiometabolic complications.
About the Authors
A. V. Ott
Altai State Medical University of the Ministry of Health;
Altai Regional Cardiovascular Dispensary
Russian Federation
Barnaul
Competing Interests:
Russian Federation
Barnaul
Competing Interests:
Конфликта интересов нет
G. A. Chumakova
Altai State Medical University of the Ministry of Health;
Research Institute for Complex Issues of
Cardiovascular Diseases
Russian Federation
Competing Interests: Конфликта интересов нет
Russian Federation
Barnaul,
Kemerovo
Competing Interests: Конфликта интересов нет
N. G. Veselovskaya
Altai State Medical University of the Ministry of Health;
Research Institute for Complex Issues of
Cardiovascular Diseases
Russian Federation
Competing Interests: Конфликта интересов нет
Russian Federation
Barnaul,
Kemerovo
Competing Interests: Конфликта интересов нет
References
1. Romantsova T.I. The obesity epidemic: obvious and probable causes. Obesity and metabolism 2011; 1: 5-19. Russian (Романцова Т.И.Эпидемия ожирения: очевидные и вероятные причины. Ожирение и метаболизм 2011; 1: 5-19).
2. World Health Organisation. Global Health Risks: mortality and burden of disease attributable to selected major risks. 2009. http://www.who.int/healthinfo/global_burden_disease/global_health_risks/en/index.html (18 Dec 2009)
3. Muromtseva G.A. et al. The prevalence of risk factors noninfectious diseases in Russian population in 2012-2013. Survey ESSAY-RF. Cardiovascular therapy and prevention 2014; 13 (6): 4-11. Russian (Муромцева Г.А. и др. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012-2013 гг. Результаты исследования ЭССЕ-РФ. Кардиоваскулярная терапия и профилактика 2014; 13(6): 4-11).
4. Andrew H. Talman, Peter J. Psaltis, James D. Cameron et al. Epicardial adipose tissue: far more than a fat depot. Cardiovasc Diagn Ther 2014;4(6):416-29.
5. McLean DS, Stillman AE. Epicardial adipose tissue as a cardiovascular risk marker. Clin Lipidol 2009;4:55-62.
6. Veselovskaya N.G., Chumakova G.A., Kozarenko A.A. et al. Adipokines as the corrected risk factor of cardiovascular diseases. Russian cardiological journal. 2010;6:88-93. Russian (Веселовская Н.Г., Чумакова Г.А., Козаренко А.А. и др. Адипокины как корригируемые факторы риска сердечно-сосудистых заболеваний. Российский кардиологический журнал 2010; 6: 88-93).
7. Yingjiang Zhou, Liangyou Rui. Leptin signaling and leptin resistance. Front Med. 2013; 7(2): 207–22.
8. Blüher S, Mantzoros CS. Leptin in humans: lessons from translational research. Am J Clin Nutr. 2009; 89(3): 991S-997S.
9. Chumakova G.A., Veselovskaya N.G., Kozarenko A.A. et al. Epicardial obesity as the probable marker of metabolic syndrome. Cardiosomatics 2012; 4: 38-43. Russian (Чумакова Г.А., Веселовская Н.Г., Козаренко А.А. и др. Эпикардиальное ожирение как возможный маркер метаболического синдрома. Кардиосоматика 2012;4:38-43).
10. Chumakova G.A., Veselovskaya N.G., Ott A.V.et al. Noninvasive markers of insulin resistance in obesity patients. Russian cardiological journal 2013; 6: 28-33. Russian (Чумакова Г.А., Веселовская Н.Г., Отт А.В. и др. Неинвазивный маркёр инсулинорезистентности у пациентов с ожирением. Российский кардиологический журнал 2013; 6: 28-33).
11. Liu J, Fox CS, Hickson D et al. Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson heart study. Diabetes Care 2010; 33:1635-39.
12. Litwin SE. Normal weight obesity: is bigge really badder? Circ Cardiovasc Imaging 2012; 5: 286–88.
13. Hung Hsuchou, Bhavaani Jayaram, Abba J. Kastin et al. Endothelial cell leptin receptor mutant mice have hyperleptinemia and reduced tissue uptake. J Cell Physiol. 2013; 228(7): 1610–16.
14. Linda A Marino-Ortega, Adiel Molina-Bello, Julio C Polanco-García et al. Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs. Int J Clin Exp Med 2015; 8(7): 11260-67.
15. Guilherme AVJ, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Cell Biol. 2008; 9: 367–77.
16. Donoso MA, Muñoz-Calvo MT, Barrios V. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013; 80(5): 363-70
Supplementary files
|
1. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(93KB)
|
Indexing metadata ▾ | |
|
|
2. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(79KB)
|
Indexing metadata ▾ | |
|
|
3. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(53KB)
|
Indexing metadata ▾ | |
|
|
4. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(41KB)
|
Indexing metadata ▾ | |
|
5. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(86KB)
|
Indexing metadata ▾ | |
|
|
6. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(55KB)
|
Indexing metadata ▾ | |
|
|
7. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(51KB)
|
Indexing metadata ▾ | |
|
|
8. Неозаглавлен | |
| Subject | ||
| Type | Other | |
Download
(47KB)
|
Indexing metadata ▾ | |
Review
For citations:
Ott A.V., Chumakova G.A., Veselovskaya N.G. A RESISTANCE TO LEPTIN IN DEVELOPMENT OF DIFFERENT OBESITY PHENOTYPES. Russian Journal of Cardiology. 2016;(4):14-18. (In Russ.) https://doi.org/10.15829/1560-4071-2016-4-14-18
Views:
2379
Email this article 