The study included 15patients with coronary heart disease (CHD), post-infarction cardiosclerosis, and chronic left ventricular (LV) aneurysm. All patients underwent interventional myocardial revascularization and Dor aneurysmectomy. Myocardial scintigraphy with ^99mTc-MYOVIEW was performed at baseline (during nitroglycerine test and at rest), and 3-4 weeks after revascularization (at rest). According to baseline scintigraphy at rest data, 35 % of the segments were hypoperfused, and in 20 % the agent did not accumulate. After sublingual nitroglycerine administration, hypo- and non-perfused segment percentage reduced to 24 % and 11 %, respectively, after revascularization - to 24 % and 11 %. Single-photon emission computed tomography with ^99mTc-MYOVIEW, combined with sublingual nitroglycerin test, identifies viable myocardial zones in post-infarction LV aneurism area and might be used for predicting post-revascularization LV function recovery.

In total, 145patients with Stage 3 essential arterial hypertension (AH) were examined, including 55 individuals without diabetes mellitus (DM), 90 subjects with AH and severe Type 2 DM (in 34, total or partial plantar amputation was performed, due to diabetic foot syndrome). In patients with AH and Type 2 DM, lower extremity microcirculatory blood flow was significantly reduced; pathological microcirculation types and severe endothelial dysfunction (laser Doppler flowmetry and plasma markers) were maximally manifested in individuals after amputation. Simvastatin therapy, as a part of complex treatment, improved lower extremity microcirculation and endothelial function inpatients with AH, Type 2 DM, and normostatic or congestive-spastic microcirculation types.

In 34 women with stable coronary heart disease (CHD), heart rate variability (HVR) and trans-esophageal atrial stimulation parameters were examined after the first atrial fibrillation (AF) paroxysm. Prognostic value of these parameters in recurrent AFparoxysm risk assessment was investigated. In patients with recurrent AF paroxysm developed in the next 6 months (Group 1), HRV parameters were significantly increased, and AF paroxysm >15 s was induced by trans-esophageal stimulation in 50 % of the subjects. In Group 2 (sinus rhythm lasting for 6 months), this rate was 14, 3 % only. HRV parameters and AF paroxysm induction in trans-esophageal stimulation could be used for recurrent AF paroxysm risk assessment.

The assessment of reperfusion effectiveness in acute myocardial infarction (AMI) is an important clinical task. In 106 AMI patients with ST elevation, the dynamics of ST segment and Twave was analyzed using the data of three electrocardiograms (baseline, 3 and 48 hours after thrombolysis - ECG-1, 2, and 3, respectively). Separately for anterior and поп-anterior AMI, ST decrease degree in the lead with its maximal elevation (STmax decrease aAMI, naAMI), as well as decrease in total ST elevation in all leads with its elevation (STsum decrease aAMI, naAMI) were analyzed. Other parameters calculated included summary T wave amplitudes in leads with ST elevation on ECG-2 and ECG-3 (sumT2, sumT3), their difference between ECG-2 and ECG-3 (sumT2-sumT1) or between ECG-3 and ECG-1 (sumT3-sumT1). Reperfusion effectiveness was assessed by local left ventricular contractility index reduction 10±3 days after thrombolysis. Sensitivity and specificity of these criteria, with calculated cut-off levels, were as follows: sumT3-sumTl?28*: 68 and 76 %; STsum decrease aAMI >44, 0 % - 81 and 62 %; STsum decrease naAMI >58, 8 %* - 100 and 42 %; STmax decrease naAMI>66, 7 %* - 83 and 53 %; STmax decrease aAMI>33, 3 %* - 81 and 54 %; sumT3<10* - 98 and 30 %; sumT2-sumT1?28* - 39 and 86 %; sumT2<14 -75 and 43 % (*p<0, 05). Analyzing simple electrocardiography parameters could facilitate the assessment of myocardial reperfusion effectiveness in AMI.

The study compared hypothiazide and verospiron effects on platelet aggregation inpatients with arterial hypertension (AH) and abdominal obesity (АО). The first group (n=28) received hypothiazide for 16 weeks, the second group (n=23) was administered verospiron for the same period. Dynamics of lipid profile, plasma and platelet lipid peroxidation products, blood and platelet antioxidant potential, as well as platelet aggregation activity, were assessed. The data were analysed using Student t test. Inpatients with AH and АО, verospiron therapy had beneficial effects on peroxidation syndrome and platelet aggregation. Long-term verospiron therapy could provide more sustainable effects. Hypothiazide did not affect the parameters assessed. To reduce body weight in patients with AH and АО, verospiron therapy should be combined with non-pharmaceutical methods.

The study is focused on cardiovascular disease and mortality dynamics in teleuts, living in a specific Western Siberia region (Kuzbass), situated in ecologically adverse intra-mountain basin with very high urbanization level. The rural teleut population represents one of so called small nations. The study (2005-2006) demonstrated arterial hypertension prevalence and 35-year mortality dynamics in teleut population.

Physical efficiency was studied in 142 male students with risk factors of atherosclerosis who had endothelial dysfunction and disturbed vegetative reactivity. High values of rate - pressure product at rest and low level of physical efficiency were found in these subjects. All that indirectly testified to the decrease in oxygen transporting, "recipient" and maximum aerobic resources in young men with risk factors of atherosclerosis and endothelial dysfunction. Relationship of low physical efficiency with endothelial dysfunction and disturbance in vegetative reactivity was found in this study. Therefore, endothelial dysfunction in students with risk factors of atherosclerosis limits functional reserve of energy formation and physical efficiency indicating low level of somatic health of these subjects.

The real-world, out-patient potential of therapeutic education (ТЕ) among individuals with Type 2 diabetes mellitus (DM-2) and arterial hypertension (AH) was investigated. Provided physicians were interested and motivated to participate, the effectiveness of this ТЕ program was no less than that for DM and AH Schools. The method could be recommended as an addition to multidisciplinary, integrated management of such patients, or as an alternative, if no Schools are available.

Antiarrhtytmic medication classification (AMC) was proposed by V. Williams and modified by D. Harrison in the time when antiarrhythmic activity of cardiac receptor and ion channel activators was less known, and their effects on bilipid sarcolemma layer was not regarded as a method for bioelectrical myocardial instability correction. The authors propose to divide all antiarrhythmic medications into four groups: ion channel function modulators, cardiac receptor modulators, ion pump function modulators, and membrane protectors. Each class is divided into sub-classes and groups.