To identify main hemodynamic, renal and electrolytic disturbances in 514 patients with primary arterial hypertension (AH) and AH-compromised family history (172 men, 342 women aged 16-72 years), as well as in 254 patients (91 men, 163 women aged 24-66 years) with АН-free family history, the following procedures were performed at cardiology in-patient department: blood pressure dynamics assessment during antihypertensive therapy, echocardiography, Doppler ultrasound, retinocapillaroscopy, dynamic renoscintigraphy, renal ultrasound, renoradiography, excretory urography, renal artery angiography, renal electrolyte and uroprotein excretion assessment. Inpatients with AH in family history, AH was significantly associated with left ventricular hypertrophy, retinoangiopathy, congenital renal and renovascular malformations, together with renal dysfunction, increased glomerular filtration rate and uroprotein excretion.

The authors discuss the role of renal arterial hypertension etiology (chronic glomerulonephritis, chronic pyelonephritis) in myocardial hypertrophy development and the association between 24-hour blood pressure monitoring parameters and left ventricular myocardial mass.

In 128 patients with Type 1 diabetes mellitus (DM-1) and 38 healthy volunteers, hemodynamic component of gas-transporting system was assessed in bicycle stress test, with permanent monitoring of О₂ consumption, heart rate (HR), systolic and diastolic blood pressure (SBP, DBP). O₂ pulse was calculated, and anaerobic threshold was determined. DM-1 patients were divided into three groups: Group 1 - without clinically manifested microangiopathy; Groups 2 and 3 -with initial and progressed manifestation of late diabetic syndrome. In all three groups, comparing to controls, mean peak О2 consumption and anaerobic threshold were significantly decreased. HR at peak stress was significantly lower inpatients with late diabetic complications than in controls, and О₂ pulse was reduced in all three groups. During stress testing, Group 1 demonstrated significant SBP increase, Groups 2 and 3 - significant DBP increase, comparing to respective control levels. In DM-1 patients, disturbances of gas-transporting system hemodynamic component, registered during stress testing, develop before clinical microangiopathy manifestation. The latter progresses substantially during late diabetic syndrome evolution.

In 128 patients with Type 1 diabetes mellitus (DM-1) and 38 healthy volunteers, hemodynamic component of gas-transporting system was assessed in bicycle stress test, with permanent monitoring of О₂ consumption, heart rate (HR), systolic and diastolic blood pressure (SBP, DBP). O₂ pulse was calculated, and anaerobic threshold was determined. DM-1 patients were divided into three groups: Group 1 - without clinically manifested microangiopathy; Groups 2 and 3 -with initial and progressed manifestation of late diabetic syndrome. In all three groups, comparing to controls, mean peak О2 consumption and anaerobic threshold were significantly decreased. HR at peak stress was significantly lower inpatients with late diabetic complications than in controls, and О₂ pulse was reduced in all three groups. During stress testing, Group 1 demonstrated significant SBP increase, Groups 2 and 3 - significant DBP increase, comparing to respective control levels. In DM-1 patients, disturbances of gas-transporting system hemodynamic component, registered during stress testing, develop before clinical microangiopathy manifestation. The latter progresses substantially during late diabetic syndrome evolution.

The aim of the study was to assess long-term cardiovascular function in myocardial infarction (MI) patients who underwent thrombolysis and interventional or conservative treatment. In total, 40 patients in acute MI phase underwent systemic thrombolysis with alteplase or streptokinase. Diagnostic coronary angiography was performed at Day 2-21, demonstrating multi-vessel pathology. Interventional treatment was recommended to all participants. Coronary bypass surgery was performed in 22 individuals, 2,65 ± 0,35 months after MI. Control group included 18 patients who refused to undergo coronary intervention. Before the intervention and one year later, treadmill test and echocardiography were performed in all participants. In MI patients with multi-vessel pathology, effective systemic thrombolysis and coronary bypass surgery improved left ventricular (IV) contractility (one year later, IV ejection fraction increased from 46,7% to 50,9%). long-term results were influenced by time factor: after planned interventions, threshold capacity increase was associated with the increased in poor prognostic test results. Thrombolytic therapy and planned coronary bypass surgery improve long-term prognosis in MI patients with multi-vessel pathology.

In total, 62patients with mild to moderate arterial hypertension underwent echocardiography and Doppler cardiography. For 12 weeks, all participants received spirapril, 6 mg/d. Spirapril therapy was associated with reduced left ventricular hypertrophy and pathological heart remodeling type number.

Captopril and fosinopril potential in correcting vascular wall anti-aggregation activity among patients with arterial hypertension (AH) and metabolic syndrome (MS) has been examined. Sixteen-week fosinopril therapy was associated with vascular wall anti-aggregation activity correction. Captopril therapy did not demonstrate similar effects in the given follow-up period. For body weight reduction, fosinopril treatment should be combined with non-pharmaceutical measures.

In 445 patients after Q-wave myocardial infarction, Q-IM (mean age 54,3 years; 433 men, 12 women), echocardiography parameters of left ventricular (LV) remodeling were examined after the discharge, 6 and 12 months later. Sphericity index, systolic myocardial stress and relative heart wall thickness parameters were calculated. All patients were randomized into three intervention groups: Group I (n=87) received standard therapy (metoprolol, aspirin, statins, other medications if necessary); plus enalapril and trimetazidine; Group II (n=105) - trimetazidine; Group III (n=108) - enalapril. Control group (n=145), receiving standard therapy only, was matched by gender, age, and myocardial damage type. Six months later, echocardiography LV remodeling parameters improved in all three intervention groups (especially in trimetazidine plus enalapril group), remaining unchanged in the control group. One year later, LV remodeling parameters did not differ significantly from the baseline ones.

In 445 patients after Q-wave myocardial infarction, Q-IM (mean age 54,3 years; 433 men, 12 women), echocardiography parameters of left ventricular (LV) remodeling were examined after the discharge, 6 and 12 months later. Sphericity index, systolic myocardial stress and relative heart wall thickness parameters were calculated. All patients were randomized into three intervention groups: Group I (n=87) received standard therapy (metoprolol, aspirin, statins, other medications if necessary); plus enalapril and trimetazidine; Group II (n=105) - trimetazidine; Group III (n=108) - enalapril. Control group (n=145), receiving standard therapy only, was matched by gender, age, and myocardial damage type. Six months later, echocardiography LV remodeling parameters improved in all three intervention groups (especially in trimetazidine plus enalapril group), remaining unchanged in the control group. One year later, LV remodeling parameters did not differ significantly from the baseline ones.

The work was aimed at cardiovascular system status assessment in women with severe climacteric syndrome. This case-control study included 173 women with frequent hot flushes and 173 women without the symptom (control group). Anthropometry, lipid metabolism parameters, arterial hypertension (AH) and chronic heart failure rates were examined. Conclusion: severe, frequent hot flashes were associated with greater climacteric syndrome manifestation and higher rates of uncontrolled AH, resulting in diastolic heart failure.

The study was aimed at investigating lipid profile dynamics inpatients with vegetative-dyshormonal cardiopathy (VDC) of various genesis, and assessing the need for lipid-lowering therapy in this coronary heart disease-free group. Lipid levels were measured in 34 participants with VDC, pathological climax and menopause, 30 women with fibromyoma uteri, 32 - with premenstrual syndrome, and 39 - with post-castration syndrome. In all four groups, mean total cholesterol (TCH) level was higher than its Russian norm (5 mmol/l), and mean alpha-CH level was higher than the female norm of 1,2 mmol/l. Calculated on the basis of mean TCH and alpha-CH levels, atherogenicity index was below 3 in all four groups. Mild changes in low-density lipoprotein CH were observed in each group, with the minimal manifestation in premenstrual syndrome participants. Non-pharmaceutical therapy should be administered to all VDC patients; the decision on pharmaceutical treatment should be made individually.

In experimental settings, hystotoxic catecholamine doses depress cardiomyocyte contractility, induce arrhythmia, and heart arrest. Edema and hemorrhages in lung tissue and myocardium, myocardial hemomicrocirculation disturbances, significantly disturbed CO₂, O₂ partial pressure, and blood pH, plus increased acidosis are observed. Artificial lung ventilation (ALV) prevents fibrillation and heart arrest, edema and generalized lung hemorrhages after lethal catecholamine dose infusion. In addition, ALV prevents hypercapnia, acidosis, and increases blood oxygenation.