Study of the association of rs4646994 ACE gene and rs2070744 NOS3 gene polymorphisms with left ventricular remodeling and exercise-induced hypertension in professional athletes (review)
https://doi.org/10.15829/1560-4071-2026-6471
EDN: RKWAPT
Abstract
Regular high-intensity physical activity in professional athletes often leads to remodeling of the left ventricle and the formation of a "sports" heart. In addition, a common reaction of the cardiovascular system to intense, regular and prolonged exercise is the activation of the renin-angiotensin-aldosterone system, which also contributes to the formation of a certain phenotype of the heart muscle and an increase in cardiovascular risk. The aim of the review was to analyze current data on the role of rs4646994 of the ACE gene and rs2070744 of the NOS3 gene polymorphisms in the development of left ventricular remodeling and exercise-induced hypertension in professional athletes. A systematic literature search was used in PubMed, Scopus, Web of Science, eLIBRARY.RU and Cyberleninka. Original studies, systematic reviews, and meta-analyses of ACE and NOS3 polymorphisms in athletes were analyzed. The DD genotype of the rs4646994 ACE polymorphism is a risk factor for left ventricular remodeling and exercise-induced hypertension in professional athletes. The rs2070744 NOS3 polymorphism can modify vascular reactivity. Further prospective studies are needed to determine the clinical significance of genetic testing in sports medicine.
Supporting agencies: The study was carried out with a grant from the Russian Science Foundation № 25-25-20159 "The associative role of polymorphic allelic variants of the renin-angiotensin-aldosterone system genes with left ventricular remodeling and arterial hypertension in professional athletes as markers of predisposition to the formation of a "sports" heart", https://rscf.ru/project/25-25-20159, grant from the Krasnoyarsk Regional Science Foundation, in the organization: Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency
About the Authors
I. A. Suzdaleva
Voyno-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical Center
Russian Federation
Competing Interests:
Russian Federation
Irina Suzdaleva
Partizan Zheleznyak St., 1, Krasnoyarsk, 660022; Kolomenskaya str., 26, room 2, Krasnoyarsk, 660037
Competing Interests:
none
A. A. Chernova
Voyno-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical Center
Russian Federation
Competing Interests:
Russian Federation
Anna Chernova
Partizan Zheleznyak St., 1, Krasnoyarsk, 660022; Kolomenskaya str., 26, room 2, Krasnoyarsk, 660037
Competing Interests:
none
S. Y. Nikulina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Competing Interests:
Russian Federation
Svetlana Nikulina
Partizan Zheleznyak St., 1, Krasnoyarsk, 660022
Competing Interests:
none
O. O. Kardashova
Federal Siberian Research Clinical Center
Russian Federation
Competing Interests:
Russian Federation
Oksana Kardashova
Kolomenskaya str., 26, room 2, Krasnoyarsk, 660037
Competing Interests:
none
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- Regular intense physical activity in professional athletes leads to the development of adaptive remodeling of the left ventricle, accompanied by exercise-induced hypertension.
- Studying the polymorphisms of genes ACE and NOS3 responsible for the development of left ventricular remodeling and exercise-induced hypertension, as well as the interaction of genes with each other and environmental factors, will help in the development of a genetic panel for a comprehensive assessment of cardiovascular risk in athletes.
Review
For citations:
Suzdaleva I.A., Chernova A.A., Nikulina S.Y., Kardashova O.O. Study of the association of rs4646994 ACE gene and rs2070744 NOS3 gene polymorphisms with left ventricular remodeling and exercise-induced hypertension in professional athletes (review). Russian Journal of Cardiology. 2026;31(1S):6471. (In Russ.) https://doi.org/10.15829/1560-4071-2026-6471. EDN: RKWAPT
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