Interventional and conservative treatment effectiveness in thrombolysed patients with myocardial infarction

Abstract

The aim of the study was to assess long-term cardiovascular function in myocardial infarction (MI) patients who underwent thrombolysis and interventional or conservative treatment. In total, 40 patients in acute MI phase underwent systemic thrombolysis with alteplase or streptokinase. Diagnostic coronary angiography was performed at Day 2-21, demonstrating multi-vessel pathology. Interventional treatment was recommended to all participants. Coronary bypass surgery was performed in 22 individuals, 2,65 ± 0,35 months after MI. Control group included 18 patients who refused to undergo coronary intervention. Before the intervention and one year later, treadmill test and echocardiography were performed in all participants. In MI patients with multi-vessel pathology, effective systemic thrombolysis and coronary bypass surgery improved left ventricular (IV) contractility (one year later, IV ejection fraction increased from 46,7% to 50,9%). long-term results were influenced by time factor: after planned interventions, threshold capacity increase was associated with the increased in poor prognostic test results. Thrombolytic therapy and planned coronary bypass surgery improve long-term prognosis in MI patients with multi-vessel pathology.