RELATION OF HYPERURICAEMIA, RENAL FUNCTION AND ARTERIAL HYPERTENSION IN A LARGE REGION OF THE EASTERN SIBERIA INHABITANTS

Aim. To investigate on the prevalence of hyperuricaemia (HU) among citizens and rural areas inhabitants of Krasnoyarsk region, and to assess possible relation of HU with arterial hypertansion (AH), HU and renal function.

Material and methods. The study was done under the framework of ESSE-RF, included 1603 persons of age 25-64, had been selected by the random three-stage stratified selection. All participants underwent questionning, office BP measurement. Uric acid level (UA) was measured with urease method on Architect 8000 (USA) equipment. Statistics was done on IBM SPSS v. 22, StatSoft STATISTICA v. 10 and LibreOffice v. 5. Significance of differences by quantitative criteria was checked with Mann-Whitney criteria, by qualitative criteria — by hi-square. Differences were significant at p<0,01.

Results. The prevalence of HU in general was 30,2% among participants, with the mean UA level 338,5 mM/L (males had significantly higher). The significant higher levels were revealed in citizens than in rural inhabitants. There was no significant difference in UA level through age subgroups. Part of hypertensives was 1,27 times more than in those with normal UA (57,7% versus 45,7%), and 1,36 more prevalent in females (57,1% versus 42,1%). The similar was found in comparison of hypertensives among hyperuricaemics, and AH prevalence in Krasnoyarsk region (57,7% versus 49,4%), and almost completely due to females prevalence (57,1% versus 43,7%). The calculated glomerular filtration rate was significantly lower in HU persons than in those with normal UA.

Conclusion. A relatively high prevalence of HU was found in the territories of Krasnoyarsk region, showing higher levels than those by ESSE-RF results. In males the disordered UA level is higher than in females and more prevalent. Citizens have HU more prevalent than rural inhabitants. The relative risk of hypertension development increases in HU more than in persons with normal UA. In HU functional kidney condition is significantly impaired.

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