HEART-TYPE FATTY ACID BINDING PROTEIN-BASED ExPRESS TEST IN THE DIAGNOSTICS OF ACUTE MYOCARDIAL INFARCTION
https://doi.org/10.15829/1560-4071-2014-2-84-88
Abstract
Troponin I WB-Check-1 in the diagnostics of acute myocardial infarction (AMI).
Material and methods. The study included 38 patients who were hospitalised with
the acute coronary syndrome (ACS) diagnosis within the first 12 hours after the pain
onset. At the admission, the peripheral blood levels of CK-MB and troponin I were
qualitatively assessed using the immunochemiluminescent analyser “Access-2”
(Beckman Coulter, USA). In addition, the express test Troponin I WB-Check-1
(VEDALAB, France; sensitivity 1 ng/ml) was used. Qualitative assessment of hearttype
fatty acid binding protein (hFABP) was performed with the express test
“CardioFABP” (Biotest, Russia; sensitivity 15 ng/ml). For all tests, diagnostic
sensitivity, diagnostic specificity, positive and negative predictive value, and
diagnostic effectiveness were assessed.
Results. The express tests for hFABP and troponin I demonstrated high positive
predictive value and diagnostic specificity (100%). However, both tests also had false
negative results, and, therefore, negative predictive value was low for both the hFABP
test (23,5%) and the troponin I test (17,4%). Diagnostic sensitivity was 35,4% for the
troponin I express test and 57,6% for the hFABP express test. Diagnostic effectiveness
was higher for the hFABP express test (62,2%). All positive results of the hFABP
express test were confirmed by the other tests, which resulted in high positive
predictive value (100%) and high diagnostic specificity (100%). In patients within the
first 6 hours of ACS, diagnostic sensitivity of the hFABP express test was significantly
higher than in those with a longer ACS duration (83,3% vs. 42,8%, respectively).
Conclusion. The higher diagnostic sensitivity and diagnostic effectiveness of the
hFABP-based express test in the first 6 hours of ACS, compared to a qualitative
assessment of troponin I and a later assessment of hFABP, agrees with the earlier
obtained data and confirms the status of hFABP as the earliest marker of myocardial
necrosis.
About the Authors
V. V. RyabovRussian Federation
M. A. Kirgizova
Russian Federation
V. A. Markov
Russian Federation
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Review
For citations:
Ryabov V.V., Kirgizova M.A., Markov V.A. HEART-TYPE FATTY ACID BINDING PROTEIN-BASED ExPRESS TEST IN THE DIAGNOSTICS OF ACUTE MYOCARDIAL INFARCTION. Russian Journal of Cardiology. 2014;(2):84-88. (In Russ.) https://doi.org/10.15829/1560-4071-2014-2-84-88