The study included 86 patients aged 42;57 years, with Stage II essential arterial hypertension (AH) and no antihyperten; sive therapy during the study. All participants underwent 24;hour blood pressure (BP) monitoring, diagnostic transesophageal left atrium electrostimulation, and echocardiography. QT interval length and dispersion, as well as RR interval variability (SDNN) were analyzed. In AH patients, left ventricular hypertrophy (LVH), metabolic syndrome and pathologic types of cir; cadian BP profile were associated with sino;atrial node function suppression, and increased atrial and ventricular electric instability. Adverse electrophysiologic prognostic parameters, cardiac rhythm disturbance predictors, were diagnosed in high; risk group by 3;5 times more often than in patients without LVH or MS and with normal circadian BP profile. Therefore, car; diac electric remodeling, associated with LVH, MS, and circadian BP rhythm disturbances, increased electric instability and arrhythmia risk.

The aim of the study was to assess hypocaloric diet effects on platelet aggregation and their mechanisms in patients with arterial hypertension (AH), android obesity (AO), and impaired glucose tolerance (IGT). In total, 25 middle;aged patients with AH, AO and IGT were examined. Anthropometry, assessment of lipid profile, plasma and platelet lipid peroxidation, and platelet hemostasis were performed. All participants received hypocaloric diet for 24 weeks. In patients with AH, AO and IGT, hypocaloric diet improved lipid profile, suppressed peroxidation syndrome, beneficial; ly influenced intra;platelet aggregation mechanisms. Hypocaloric diet also decreased in vitro platelet adhesion and aggrega;
tion, especially by the end of 24;week intervention, even though control levels were not achieved. Conclusion. For adequate correction of metabolism and platelet hemostasis in patients with AH, AO and IGT, isolated administration of hypocaloric diet is not enough. Other therapeutic approaches are needed for individuals with AH, AO and IGT.

The results of myocardial cytoprotection with mildronate and trimethazidine (Preductal MB) in stable angina patients with left ventricular (LV) myocardial dysfunction, including hibernation, are presented. All participants underwent transluminal balloon angioplasty. Mildronate and trimethazidine therapy was associated with decrease in local dyscontractility index and reduced s LV myocardial dysfunction. The latter, in its turn, was associated with improved cardiac pump function and decreased LV myocardial dysfunction.

Arterial hypertension (AH) prevalence in Type 2 diabetes mellitus (DM) was studied in adult population (aged above 18 years) of Bashkortostan Republic (BR), according to WHO/ISH criteria (1999). The data were taken from the BR State DM Registry (SDMR). AH prevalence (blood pressure at least 140/90 mm Hg) was 70, 1 % (73, 9 % in females, 69, 3 % in males). In women, advanced AH stages were registered more often than in males. There was a weak correlation of female gender and AH in type 2 DM (r=0, 09).

The article is devoted to cardiovascular pathology in one of the largest Russian regions - Sakha Republic (Yakutia). Noteworthy, the regional population lives in Arctic and Sub-arctic latitudes, where numerous large-scale epidemiologic and clinical cardiology studies have been performed. The author summarizes the results of 1985-1987 and 1999-2002 studies, demonstrating special features of cardiovascular risk factors, arterial hypertension, lipid profile in Yakutia native and migrant population.

The aim of the study was to determine whether anemia is an independent predictor for recurrent myocardial infarction (MI), and to interpret the results obtained, using multiple statistics method - correlation analysis. In total, 171 patients (mean age 64, 2 ± 10 years) with acute MI were examined. All participants received thrombolytic therapy. Patients with bleeding in anamnesis or sever comorbidities were excluded from the study. Red blood cell and hemoglobin levels in capillary blood were measured at admission. The following parameters were registered: elderly age, heart failure class by Killip, coronary anamnesis duration, MI, stroke, diabetes mellitus, arterial hypertension, atrial fibrillation in anamnesis, left ventricular hypertrophy and dilatation at echocardiography. Mean follow-up period lasted for 21 days; post-MI angina and recurrent MI were registered. In multiple analysis, logistic regression and correlation analysis were performed. Post-MI angina without progression into recurrent MI was observed in 62 patients. Recurrent MI was registered in 19 participants; in this group, anemia was observed more often (47, 4 %) than in individuals without recurrent angina or MI(25 %; p = 0, 002). According to univariate analysis and logistic regression results, there was no significant correlation between anemic syndrome and post-MI angina. Anemia was an independent predictor of recurrent MI (p = 0, 03; odds ratio 3, 11; 95 % CI 1, 07-9, 0). Anemia prognostic role was confirmed by correlation analysis: patients with post-MI angina and recurrent MI substantially differed from each other, as well as from other patients, by baseline characteristics. Therefore, anemic syndrome could be regarded as an independent predictor of recurrent MI. Correlation analysis is effective in assessing multiple information on acute MI patients.

Hypoxia therapy was administered to 100 patients with coronary heart disease and Functional Class I-III heart failure. Control group consisted of 50 patients. The treatment resulted in improved myocardial work capacity, coronary reserve, and quality of life.