No 4 (2008)
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ORIGINAL ARTICLES
5-15 922
Abstract
To identify the causes and mechanisms of hypertensive crise development in primary arterial hypertension (AH), complex clinical, biochemical, hormonal, hemodynamic and instrumental examination was performed in 563 patients (189 men, 374 women aged 25-66 years) with Stage I-IIIprimary AH(WHO classification, 1997) and hypertensive crises. The control group included 619 patients (207 men, 412 women aged 31-66 years) with crise-free Stage I-III primary AH. Intracardial and central hemodynamics was assessed by echocardiography, tetrapolar rheography, and radiocardiography. Instrumental urologic examination included renoradiography, static and dynamic renal scintigraphy, ultrasound and computed renal and suprarenal tomography, excretory urography, and selective angiography of renal arteries if necessary. Glomerular filtration rate was assessed by endogenous creatinine clearance, and microproteinuria - by urinary excretion of albumin and beta-2-microglobulin. Plasma levels of hypophysis, thyroid, parathyroid, suprarenal and gonad hormones, as well as excretion of FSH, IH, aldosterone, and cyclic nucleotides was measured by radio-immunologic methods. Stressogenic, psychogenic, and neurological factors influenced hypertensive crise development and pathogenesis among more than two-thirds of primary AH patients. Hyperkinetic circulation during the crise was not explained by left ventricular hypertrophy, remodelling, or chronic pathology. Aortal and retinal pathology was more prevalent in crise-free AH patients. Crise AH course was associated with hyper-secretion of hypophyseal gonadotropins and thyrotropin, suprarenal aldosterone, and changes in the ratio of cyclic nucleotides excreted with urine. Renal pathology and dysfunction at complex clinical and instrumental examination was observed in more than two-thirds of AH patients with hypertensive crises, with high prevalence of chronic uni- or bilateral renal inflammation, nephrosclerosis in calices and renal poles. Renal artery stenosis, with uni- or bilateral changes in renogram secretory phases, functioning parenchyma reduction, and increased plasma renin activity, was less prevalent. Disturbed nitrogen-excretory and filtration renal functions were not directly related to hypertensive crise development.
16-19 306
Abstract
In total, 100 men with unstable angina (UA) were randomized into two groups, comparable by age, cardiovascular anamnesis and treatment. The intervention group (n=49) received low-intensity laser radiation (LDLR) therapy, the control group (n=51) - placebo intervention. Parameters of free-radical oxidation, nitroxidergic system, and lipid profile were assessed at Days 2 and 9. Physical stress tolerance (PST) was assessed at Days 16-18, by veloergometry. In UA patients, LILR was associated with substantial decrease in atherogenic lipid profile parameters, normalization of TBA-active product levels, nitrite concentration increase, as well as significant PST improvement inpatients with Class II-II UA.
20-24 339
Abstract
The study aimed at investigating age-related changes in vascular structure and function among obese women. In total, 83 obese females and 45 women with normal weight were divided into four age subgroups. Duplex ultrasound of common carotid arteries (CCA) and brachial arteries was performed; endothelium-dependent vasodilatation (EDVD) was studied in reactive hyperemia test. Significant increase in CCA intima-media thickness (IMT), CCA IM diameter, and EDVD reduction was observed in obese women from all age groups, compared to non-obese females. There was a strong positive correlation between IMT and age-related IM diameter increase, and a weaker, but still significant correlation between IMT and body mass index or waist/hip ratio. EDVD negatively correlated with age and waist/hip ratio.
GUIDELINES FOR THE PRACTITIONER
25-33 379
Abstract
The study assessed clinical effectiveness and safety of propanorm in patients with arterial hypertension, chronic heart failure (CHF) without left ventricular systolic dysfunction, complicated with recurrent paroxysmal or persistent atrial fibrillation (AF). It was demonstrated that propanorm was effective and safe and could be combined with beta-adrenoblockers. In 29,3% of the participants, tachyarrhythmia terminated; in another 70,7% AF episode frequency reduced by 75,5%, and total time of AF episodes decreased by 81,1%.
56-60 456
Abstract
Three-month citalopram (Opra) therapy in post-infarction rehabilitation period effectively treated affective disorders, reduced psychological stress levels and improved night sleep in patients with Type 2 diabetes mellitus and chronic heart failure. Combined therapy, including Opra, was associated with reduced angina attack incidence and autonomous dysfunction symptoms, increased physical stress tolerance and quality of life, improved cardiac structure and function.
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ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)
ISSN 2618-7620 (Online)
