The aim of the study was to clarify the role of congenital anomalies of kidneys, renal vessels and urogenital organs in arterial hypertension (AH) development and progression among young men – potential military recruits undergoing medical expertise. In total, 60 men aged 16X26 years (mean age 20,2±0,7 years), with Stage IXII AH (WHO, 1997) were examined, together with 79 parents (39 fathers, 40 mothers) aged 38X61 years (mean age 47,4±0,5 years). SeventyXone parents had Stage IXIII AH, 8 (2 men, 6 women) had normal blood pressure (BP) level. Clinical and instrumental examination included dynamic and static scintigraphy, renal ultrasound, Doppler angiography, excretory urography, measurement of endogenous creatinine glomerular filtration rate, morning albuminuria, and plasma uric acid level. ABO red blood cell antigens and rhesus factor were used as genetic markers. All recruits also underwent echocardiography and 24Xhour BP monitoring during antihypertensive medicationXfree period. AH syndrome, often hereditary, was associated with various renal pathologies diagnosed via complex clinical and instrumental examination.

In 133 patients with Stage I-II essential arterial hypertension (AH), aged 38-59 years, time parameters of heart rate variability (HRV) were compared to echocardiography data on interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), LV myocardial mass index (LVMMI) and LV wall relative thickness (LVWRT). Inpatients with AH anamnesis of less than 7 years, principal HRV parameters were higher than in participants with longer AH duration. In the latter group, increased LVMMI and LVWRT were associated with reduced HRV parameters.

The study included 25 men (mean age 29,24±0,76 years) with Stage I arterial hypertension (AH-I). The control group consisted of 25 healthy men (mean age 30,27±0,59 years). All groups underwent 24-hour blood pressure monitoring (BPM), echocardiography (EchoCG) with Doppler ultrasound, heart rate variability (HRV) assessment, and cholesterol fraction measurement. Analyzing the correlations between vegetative parameters, levels of cholesterol and its fractions, myocardial morphology and function, it has been demonstrated that in AH-I patients, the number and strength of correlations are higher than in healthy participants. This points to a possibility of more rigid neuro-humoral cardiovascular regulation in AH-I patients, comparing to healthy individuals.

То predict heart failure (HF) in 192 patients with Q-wave myocardial infarction (Q-MI), a brief cardiac volume load (VI) test was performed at MI Day 3. Group I included 50 patients with Q-MI and HF II (Killip) (n=50), Group II- 108 patients with Q-MI and no HF (left ventricular ejection fraction, IVEF >40 %), Group III - 34patients with Q-MI, no HF (IVEF>40 %), but with pathologic VI test reaction. These participants received alpha-blocking beta-blocker carvedilol instead ofmetoprolol. The control group included 20 healthy people. In controls, VI test was associated with improved IV systolic and diastolic functions (SF, DF); IV form became more ellipsoid (normal VI reaction). In Group I, VL test was associated with disturbances in SF and IV filling structure; IF form became more spheroid (pathologic reaction). In Group II, normal reaction was observed in 40 %, pathologic reaction - in 60 %. During one-year follow-up period, HF developed only in patients with pathologic VI reaction (28,1 %). long-term carvedilol therapy reduced HF incidence inpatients with uncomplicated Q-MI and pathologic VI reaction, from 28,1 % to 11,8 % (p<0,05).

In total, 70 patients with coronary heart disease (CHD) and Functional Class II-III(NYHA) chronic heart failure (CHF) were administered standard treatment combined with hirudotherapy. In more than 50% of the participants, dyspnoea and peripheral edema reduction, plus increased physical stress tolerance, were observed. In hypertensive patients, diastolic blood pressure significantly decreased, and ejection fraction increased. Hemostasis changes manifested in reduced platelet aggregation and normalized fibrinogen and SFMC levels.

Adrenal morphology and function were studied in intensively treated patients with Q-wave acute myocardial infarction (AMI). Adequate analgetic and thrombolytic therapy, as well as beta-adrenoblocker treatment, prevented adrenal medulla depletion. Contralateral adrenal reaction was heterogeneous. The results obtained provide a better understanding of adaptive reactions and medication action mechanisms in intensively treated patients with Q-wave AMI.

The study aimed to assess real-world clinical practice effectiveness and safety of simvastatin therapy in climacteric women. A prospective cohort study included 82post-menopausal women with lipid-lowering therapy indications; median age 56,5 (52,0-60,0) years. Simvastatin therapy lasted for one year. After three months of the treatment, total cholesterol (TCH) level significantly reduced, due to decreased low-density lipoprotein (LDL) CH, athemgenicity index decreased, and high to low-density lipoprotein CH ratio increased. Levels of triglycerides and high-density lipoprotein CH remained the same, as well as liver enzyme activity. Neuro-vegetative symptoms of climacteric syndrome become less manifested. Ln climacteric women, long-term simvastatin therapy controlled lipid metabolism effectively and safely.

The study aimed at identifying rapid methods of platelet (PL) hemostasis normalization in patients with arterial hypertension (AH) and metabolic syndrome (MS). Three-month therapy course, including hypocaloric diet, dosed physical exercise, pioglar and valsartan, was administered to 35patients with AH and MS. Plasma and PL lipid peroxidation dynamics, blood and PL antioxidant potential, PL hemostasis parameters were assessed. Statistical analysis included Student's t-test. Three-month complex therapy normalized primary hemostasis and reduced peroxidation syndrome in AH and MS patients. Longer treatment will strengthen the achieved beneficial effect.

In laboratory white rats, intravenous VEGF-164 injection and left coronary artery occlusion resulted in myocardial infarction development by Bay 7. In perinecrotic zone and distal areas, the increase in capillary density and exchange surface area was observed, comparing to control animals with coronary occlusion only. Therefore, VEGF-164 agent stimulated myocardial angiogenesis, with potential anti-ischemic effect, decreased necrosis area, and reduced myocardial structure reorganization.

This review focuses on liver, pancreas, and kidney dysfunction in patients after Fontaine operation.