To investigate arterial hypertension (AH) influence on stress-induced arrhythmias in coronary heart disease (CRT)) patients, we examined 196 males with previously verified CRT) and various stages of AH. All participants underwent echocardiography, bicycle stress test (BST); corrected cQT(cQT) dispersion at baseline and during BST, as well as recovery time of initial dispersion and ST segment, were calculated. AH, especially severe AH, was a risk factor for stress-induced ventricular extrasystolia (VES) in CHD patients, by promoting left ventricular hypertrophy (LVH) and myocardial electrical heterogeneity. In CHD patients with stress-induced VES, comparing to VES-free individuals, myocardial electric heterogeneity was maximal during stress tests, increasing at the very beginning of the tests. These results can be used in predicting cardiac arrhythmias incidence during physical stress.

Mechanisms of vascular tonus regulation in patients with essential arterial hypertension (EAR) and chronic heart failure (CHF) were examined by high-definition ultrasound method. EAH patients demonstrated substantially disturbed endothelium-dependent mechanisms of vascular tonus regulation, with intact endothelium-independent mechanisms. In CHE individuals, both endothelium-dependent and independent vascular reactions were disturbed. The observed changes in vasomotor reactions might precede morphological changes in vascular wall.

Heart remodeling, heart rate variability, QT dispersion, and myocardial ectopic activity were studied in arterial hypertension (AH) patients, according to their gender and age. In total, 387 individuals with AH were examined: 189 males, and 198 females. The control group included 195 relatively healthy persons (99 males, 96 females). All participants underwent echocardiography, and Hotter ECG monitoring. Hypertensive males demonstrated sympathic hypertonus, cQT dispersion, and higher rate of potentially dangerous ventricular arrhythmias, that was associated with increased risk of sudden arrhythmic death, and concentric left ventricular hypertrophy (LVH). In females aged 50-59, eccentric IVHwas more prevalent. Greater structural and functional disturbances in males could be explained by more frequent (85 %) combination of AH and coronary heart disease (CHD); 92 % > of females had isolated AH.

The aim of the study was to investigate remodeling and stiffness of elastic and muscle-type arterial walls in elderly arterial hypertension (ElAH) patients, in comparison with their relatively healthy peers. The study included 66 ElAH patients and 28 age- and gender-matched controls, with normal blood pressure (BP) levels. Ultrasound examination of brachial and common carotid arteries was performed; ultrasound vascular anatomy and stiffness parameters (pulse wave velocity, Yung and Peterson modules, circumference tension) were assessed. In ElAH, increased arterial stiffness, due to its active and passive components, was observed for both elastic and muscle-type arteries. In ElAH patients, carotid artery remodeling was more advanced than that for brachial artery. The most sensitive parameter of muscle-type artery remodeling was wall: lumen ratio.

To assess the effects of arterial hypertension (AH) and abdominal adiposity (AA) on gonarthrosis clinics, three groups of females, according to AH and/or adiposity presence, were examined. Even mild AH affected gonarthrosis clinics. The most unfavorable combination of AH and AA affected not only anthropometric parameters, intracardial hemodynamics, lipid and carbohydrate metabolism abnormalities, but also gonarthrosis clinical manifestations, increasing severity of pain syndrome and joint functional insufficiency.

Pathologic left ventricular (LV) remodeling was registered in 96. 4 % of patients with arterial hypertension (AH) and rheumatoid arthritis (RA). For AH patients, concentric LV hypertrophy (LVH) was quite typical (85 %); RA patients demonstrated similar prevalence of all LVH types: eccentric LVH (22.3 % > ), concentric LVH (27.2 % > ), concentric remodeling (36.9 %). Ln individuals with RA and AH, LV remodeling structure was similar to that in RA-free hypertensive patients. For early RA debut, eccentric LVH was more typical; development of concentric LVH depended mostly on AH characteristics. Ln combination ofRA and AH, LV systolic dysfunction was relatively rare; at the same time, silent diastolic dysfunction (DD) was registered in 70 % > of cases. Silent DD, detected during stress echocardiography, was observed in 24 % > of patients with AH and RA; Type 1 DD - in 46 % >.

Aorta and brachiocephalic artery atherosclerosis in various types of dyslipidemia (DLP) were examined. Twenty-six participant demonstrated combination of aortic and coronary or cerebral atherosclerosis: 5 patients had aortic isthmus stenosis, 8 -abdominal aortic aneurysm, 8 - bifurcation stenosis, 9 - carotid artery stenosis. Abdominal aortic aneurysm, aorta isthmus stenosis, and bifurcation stenosis were typical for familial hypercholesterolemia, carotid artery stenosis - for hypertriglyceridemia, or very low levels of high-density lipoprotein cholesterol (HDL CH). During 6-10 years of follow-up, among 21 patients (other 9 had dropped out), 6 patients died, and 9 patients underwent surgery: aortic or carotid intervention (n=3 and 6, respectively). Patients with DLP require aggressive treatment with statins orfibrates, according to DLP type, and continuous Doppler ultrasound monitoring of aorta and carotid artery morphology.

This article is focused on myocardial cytoprotectors - mildronate and trimethazidine (Preductal MB) - influence on free-radical myocardial processes in stable angina patients before and after transluminal coronary angioplasty and coronary stenting. Administration of these medications before myocardial revascularization facilitated decrease in free-radical peroxidation, due to activation of protective antioxidant enzymes.

This study is devoted to systemic enzyme therapy (wobenzym and phlogenzym) influence on hemostasis, hemorheology, and clinical course of disease inpatients (n=54) with Functional Class II-III effort angina, receiving complex therapy. Systemic enzyme therapy improved blood rheology due to decreased red and white blood cell aggregation, increased elasticity of red blood cell membrane; optimized fibrinolysis and hemocoagulation systems' status; improved angina clinical course and quality of life. Including wobenzym and phlogenzym into complex therapy ofFC II-III effort angina patients is clinically rational, effective, and safe.

The aim of this study was to investigate microcirculatory (M) changes and andothelin-1 levels in 3-month indapamide treatment. The study included 22patients with essential arterial hypertension (EAH), Stage I-II, and 12 normotensive controls. Microcirculation was assessed by laser Dopplerflowmetry, endothelin-1 level - by enzyme immunoassay method. The EAH patients demonstrated M heterogeneity, with high prevalence of pathologic M types. Indapamide was effective and safe in EAH treatment, improving M status. Serum levels of endothelin-1 correlated with Doppler flowmetric indices - Aa/IM, alpha-rhythm amplitude, as well as with blood pressure levels.

Using our original methodic of transthoracic Doppler assessment of coronary blood flow, we examined coronary resistance dynamics during physical stress tests in 12 patients with essential arterial hypertension (Group I), and 12 patients with effort angina (Group 2). In Group 1, physical exertion was associated with vascular resistance decrease in right coronary artery (RCA) basin by 66 %, comparing to baseline; in left coronary artery (LCA) basin - by 69 %. In Group 2, these figures were -58 % and +22 %, respectively. Coronary resistance increase among Group 2patients was associated with myocardial hypoand/or akinetic areas in LKA basin. The authors conclude that their methodic of transthoracic Doppler assessment of coronary blood flow enables clinicians to adequately evaluate coronary resistance dynamics during physical stress.

The study is devoted to the effects of artificial baths with sodium chloride, administered for one month per year, 2-3 years in a row, on physical workability, ventricular and supraventricular extrasystolia, pain-manifested and silent myocardial ischemia in coronary heart disease (CHD) out-patients with stable angina. Treatment efficacy was assessed by spiroveloergometry and Hotter ECG monitoring. In total, 100 patients were examined. General sodium chloride baths (one-month course for 2-3 subsequent years) demonstrated training and antiarrhythmic effects in CHD patients with extrasystolia. These beneficial effects were accompanied with improvements in physical workability and coronary heart reserve, ventricular and supraventricular extrasystolia incidence, severity of pain-manifested silent myocardial ischemia.

The study included 150 young men and women aged 16-20 (mean age 18. 2): 52 relatively healthy persons, 53 patients with vagotonic vegeto-vascular dystonia (VVD), and 45 - with sympathic VVD. All participants underwent standard clinical examination, 12-lead electrocardiography (ECG), rest cardiorhythmography at rest and during functional test with fixed breathing rate, carotid rheoencephalography. Clinical complaints were linked to autonomic cardiovascular regulation features, blood pressure (BP) liability, heart rate variability, carotid hemodynamics disturbances, external adaptation reserves. Among patients with sympathicotonic VVD, a subgroup at arterial hypertension (AH) risk could be identified, by cardiorhythmography with fixed breathing rate functional test.