In-hospital management of myocardial infarction was analyzed for 150 patients (54 women). Mean age was 59, 6+1, 1 years for men, and 69, 2+1, 1 years for women. All participants underwent thrombolysis. Patients with severe associated pathology and hemorrhage in anamnesis were excluded from the study. Red blood cell count and hemoglobin (Hb) level in capillary blood were measured at admission. Death, acute heart failure, left ventricular dysfunction (by echocardiography criteria) were registered. At discharge, anemia was observed in 42 participants. Individuals, who died from cardiogenic shock, had lowest Hb levels (128, 6 ± 4, 1 g/l), comparing to participants, who died from other causes (135, 3 ± 5, 7 g/l), and survivors (133, 1+1, 2 g/l). Anemia was an independent predictor of middle-term in-hospital mortality (odds ratio 4, 7; p < 0, 05). Predischarge ejection fraction was directly linked to Hb level at admission (t = 2, 34; p < 0, 05).

Heart rate variability was measured by cardiointervalography in 49 individuals with acute myocardial infarction (MI), during systematic physical training as a component of the out-patient rehabilitation program. Follow-up period lasted for one year. In the main group (n = 25), controlled physical training sessions, with workload of 50- 60 % from baseline level, took place twice a week. In the control group (n = 24), rehabilitation program included dosed walking, with individually calculated pace velocity. Participants were examined at baseline, 3, 6, and 12 months later. Chronic physical training decreased sympathic tonus and stabilized parasympathic tonus, normalized the work of body regulatory mechanisms. Moreover, physical training stabilized autonomic tonus and reactivity, due to declined sympathicotony. Absence of physical training resulted in significantly reduced number of patients with normal autonomic reactivity.

The study included 45 patients with coronary heart disease (CHD) and chronic heart failure (CHF) of functional class I-IV. Increased cardiac troponin T(cTnT) level could be used in verification and assessment of CHF decompensation severity. In CHF, increase in cTnT level was influenced by CHF decompensation, left ventricular systolic dysfunction and remodeling. At the same time, essential arterial hypertension, post-infarctial cardiosclerosis, permanent atrial fibrillation, left ventricular diastolic dysfunction, left atrium pathologic remodeling did not significantly influence cTnT concentration in patients with CHD and CHF.

The study included 45 patients with coronary heart disease (CHD) and chronic heart failure (CHF) of functional class I-IV. Increased cardiac troponin T(cTnT) level could be used in verification and assessment of CHF decompensation severity. In CHF, increase in cTnT level was influenced by CHF decompensation, left ventricular systolic dysfunction and remodeling. At the same time, essential arterial hypertension, post-infarctial cardiosclerosis, permanent atrial fibrillation, left ventricular diastolic dysfunction, left atrium pathologic remodeling did not significantly influence cTnT concentration in patients with CHD and CHF.

Right heart chamber hemodynamics was assessed in adolescents with various stages of scoliosis. In participants with severe scoliosis, pulmonary hypertension was detected, with increased right ventricular volume and wall thickness, as well as myocardial dysfunction.

In 54 patients with drug-resistant non-valve atrial fibrillation, causes of decreased quality of life (QoL) were studied, using the Nottingham Health Profile and Arrhythmic Patients' Life Questionnaire. The influence of hemodynamic parameters, clinical features of arrhythmia, age, and principal pathology on QoL was also investigated. Ln patients with atrial fibrillation, QoL was mostly affected by arrhythmic symptoms and associated restrictions in daily activity, worsened psycho-emotional status, sleeping disturbances. Ln this group, QoL was determined mostly not by clinical symptoms, hemodynamic parameters, principal pathology or age, but by subjective reaction to arrhythmia.

Оn-pump coronary bypass surgery was performed in 58 stable angina patients aged 43-72. Group I (n = 19) received standard coronary heart disease (CHD) treatment, together with mildronate: before the surgery, 750 mg/d for 3 days, then 750 mg/d twice a week. Group II (n = 19) received standard therapy, plus trimethazidine (Preductal MB), 70 mg/d. Group III (n = 20) did not receive any metabolic medications. Dynamics of lipid peroxidation and protective antioxidant systems status was assessed during first 24 hours after surgery. Blood samples were collected before the intervention, 6 and 24 hours later. Cardioprotectors mildronate and trimethazidin, administered before surgery, decreased blood levels of lipid peroxidation products, due to activation of protective antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GP).

In 30 patients with Type 2 diabetes mellitus (DM) and mild to moderate arterial hypertension (AH), hypotensive, antiischemic efficacy, and influence on endogenous protective systems (NO, heat shock proteins HSP 70) of a new, third-generation, cardio-selective NO-modulating beta-blocker nebivolol (nebilet) were studied. For 16 weeks, participants received nebivolol as monotherapy (2. 5-5-10 mg/d). Significant hypotensive, anti-ischemic effects of nebivolol, as well as increased endothelial NO secretion and HSP 70 synthesis, were demonstrated.

The aim of the study was to investigate hypotensive and cerebroprotective activity ofmetoprolol inpatients with essential arterial hypertension (EAR). In all participants, 24-hour blood pressure (BP) monitoring, cerebral perfusion scintigraphy, and cognitive function assessment were performed at baseline and after 6 weeks of treatment. After 6 weeks of therapy, according to 24-hour BP monitoring results, systolic and diastolic BP significantly declined. Cerebral blood flow substantially improved in parietal, frontal, and temporal areas. Cognitive function (memory, attention, thinking) also improved. Metoprolol optimally decreased BP and demonstrated cerebroprotective efficacy.