To identify the role of cardiovascular pathology, renal, renovascular and renourinal anomalies, neurogenic and endocrine diseases in arterial hypertension (AH) pathogenesis among young, call-up-aged men hospitalized for examination and primary AH diagnosis verification, 60 men aged 16-26 years were included in the study. Hemodynamics was assessed by blood pressure (BP) office measurement and ambulatory monitoring, together with B-mode echocardiography data. Renal and renourinal structure and function was assessed by static and dynamic scintigraphy, renal ultrasound, renal radiography, excretory urography, color Doppler angiography of renal arteries, measurement of microalbuminuria in morning urine and glomerular filtration rate by endogenous creatinine. Plasma levels of uric acid, red blood cell ABO antigens, and Rhesus factor were also assessed to verify familial AH predisposition. AH was not an isolated pathology, being combined with various anomalies and disorders of kidneys, renal vessels, renourinary, cardiovascular, endocrine systems, as well as with metabolic disturbances and obesity. In more than 50% of the cases, renal anomalies were explained by genetic or intrauterine factors. The results obtained point to the importance of genetic and inherited renal anomalies' role in chronic AH syndrome development among young, call-up-aged men.

According to modern views, immuno-inflammatory activation plays an important role in atrial fibrillation (AF) pathogenesis. In 97patients with arterial hypertension (AH), paroxysm and non-paroxysm levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and fibrinogen were measured in 97 patients with permanent, persisting recurrent atrial fibrillation (AF). During AF paroxysm, TNF-alpha levels were significantly increased (p = 0,0001), in contrast with relatively stable CRP and fibrinogen levels (p > 0,05). CRP inversely correlated with AF severity (p = 0,0001). TNF-alpha levels were inversely associated with high-density lipoprotein cholesterol concentration in AF-free hypertensives, AH and permanent AF individuals, and persistent recurrent AF patients during the paroxysm. AF paroxysms were linked to increased TNF-alpha concentration. The correlation between main cardiovascular risk factors and inflammatory markers was observed.

The study included 101 patients with acute Q-wave infarction. Standard examination was accompanied by assessment of myocardial repolarization dispersion assessment (Day 1 and Day 7) and Chlamydia pneumoniae and Cytomegalovirus infections. Increased fibrinogen level and Cytomegalovirus infection activity were independent risk factors of ventricular repolarization asynchrony.

Heart rate variability (HRV) dynamics was assessed in the first 24 hours of acute myocardial infarction (AMI). HRV parameters (SDNN, rMSSD, pNN50) were linked to various post-thrombolysis AMI clinical variants.

The aim of the study was to investigate the dynamics of main endogenous intoxication (EI) parameters in the first 14 days of myocardial infarction (MI), as well as to study their role in MI severity assessment. In total, 56 patients with acute Q-wave MI, hospitalized in the first 24 hours, were examined: 41 individuals without cardiogenic shock (CS), 15 patients with CS symptoms at admission. Among 15 CS patients, 12 died from progressing left ventricular failure on Days 1-2. Blood levels of creatine phosphokinase (KK), total and effective albumin (ТА, ЕА), middle-mass molecules (МММ), white blood cells (WBC), and WBS subpopulations were measured. On this basis, albumin binding reserve (ABR), toxicity index (TI), intoxication coefficient (1С), WBC intoxication index (WBC II) were calculated. Increased toxemia levels were observed through the whole study period. WBC, WBC II, KK levels peaked in the first 1-2 days of MI. TI and МММ levels were constantly increased (for at least 2 weeks), corresponding to clinical status severity. Blood Albumin and toxemia measurement facilitates rapid (in the first few post-admission minutes) assessment of clinical status severity in MI patients, therefore assisting in identifying individuals who need intensive monitoring and aggressive treatment.

The authors propose the method of individual assessment of immuno-correcting agents' effects on peripheral white blood cells activity (chemiluminescent test). In cardiosurgery patients individually selected immuno-correcting agents more effectively normalize immune status and correct immune dysbalance.

Endothelial vasoactive function was assessed in 66 children and adolescents aged 11-16 years, with obesity and metabolic syndrome (MS). Pathological result of rheovasography stress test was observed in 71,4% of MS children, pointing to endothelial dysfunction (ED) presence. In MS children, vasoconstriction was identified more often than in obese children -by 1, 77 times (p < 0,05). Therefore, there is a need for early ED correction in MS children.

In total, 156 patients with Functional Class (FC) II-III effort angina (EA) received standard therapy (beta-adrenoblockers, ACE inhibitors, disaggregants) plus trimetazide (60 mg/d) for 16 weeks. Control group included 40 patients with FC II-III EA, receiving standard therapy only. Combined therapy was associated with: nitroglycerine dose reduction; physical stress tolerance increase; decrease of qualitative and quantitative signs of pain and painless myocardial ischemia, supraventricular and ventricular extrasystoles, QC dispersion; increase in timely and spectral parameters of heart rate variability.

То assess angiotensin II receptor blocker effects on platelet aggregation in arterial hypertension (AH) and metabolic syndrome (MS), 34 patients were administered valsartanfor 16 weeks. The dynamics of anthropometry parameters, blood lipids, plasma and platelet lipid peroxidation, blood and blood cell antioxidant potential, as well as platelet aggregation was investigated. Statistical analysis included Student and systemic multi-factor analysis methods. In AH and MS patients, valsartan improved peroxidation syndrome and platelet aggregation. For weight reduction, valsartan should be combined with non-pharmaceutical methods.

The author calculated age-specific primary disability rates due to cardiovascular disease (including coronary heart disease and cerebrovascular pathology) for the period of 1996-2005. In 2004-2005, disability increased significantly, especially in retired population, that has an important practical value. Form Seven of Medico-Social Expertise Bureau was used as primary information source.