INFLUENCE OF THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON POST-OPERATION COURSE IN CORONARY HEART DISEASE

Abstract

Aim. To study the influence of chronic obstructive pulmonary disease (COPD) on post-operation period course in coronary heart disease (CHD) patients after coronary bypass surgery (CBG).

Material and methods. Totally, 92 patients included, with CHD. Two groups were formed: 1st — 50 patients with CHD, 2nd — 42 patients with CHD and COPD. We studied the condition of ventilation via bodypletismography method, and registered oxygen consumption at rest and assessed the effectiveness of pulmonary ventilation — oxygen utilization coefficient (OUC2 , mL/L). Via the method of monofactor logistic regression analysis we calculated independent predictors of cardiovascular and respiratory complications during the nearest period of CBG.

Results. After CBG the number of in-hospital complications in the 2nd group was higher than in the 1st. In 2nd group there were more prevalent respiratory failure, atrial fibrillation, cerebral function alteration. As predictor for complications after CBG was COPD (OR 2,1; CI 1,7-2,9; p=0,002). Combination of low values of the forced expiration by 1 s (FEV1) — less than 60% from normal with increase of residual volume (RV) more than 130% is significant predictor for the increase of ventilatory support (VS) (OR 2,5; CI 1,9-3,2; p=0,01). At baseline, decrease of OUC2 less than 20 mL/L is also the predictor for RS prolongation (OR 1,9; CI 1,4-2,8; p=0,003).

Conclusion. COPD in CHD increases the chances of complicated clinical course of in-hospital period 2,1 times. Such specifics of baseline disorder in ventilation system as decrease FEV1 less than 60% with increase of RV more 130%, and significant decrease of effectiveness of pulmonary ventilation — OUC2 less than 20 mL/L increase chances for RS duration after CBG 2,5 and 1,9 times, respectively.