Fatty acid binding protein as a prognostic indicator in patients with acute heart failure
https://doi.org/10.15829/1560-4071-2026-6808
EDN: NTIYNE
Abstract
Aim. To compare the prognosis of patients with acute heart failure (AHF) with positive and negative cardiac fatty acid binding protein (cFABP) tests.
Material and methods. In 63 patients hospitalized for severe Killip class III-IV AHF, cFABP was measured within the first 3 hours of symptom onset using a qualitative method with individual test kits. Patients were followed for 12 [9; 13] months. Results. Patients with a positive cFABP test had higher in-hospital and overall mortality. Troponin I levels above the 99th percentile are associated with higher long-term mortality, while N-terminal pro-brain natriuretic peptide is not associated with the death risk in patients with severe AHF.
Conclusion. cFABP can be considered a prognostic marker of adverse outcome in patients with severe AHF.
About the Authors
M. S. Bychkova
Pirogov Russian National Research Medical University
Russian Federation
Competing Interests:
Russian Federation
assistant of the Department of Propaedeutics of Internal Diseases №2 of the Institute of Clinical Medicine.
Ostrovityanova str., 1, Moscow, 117997
Competing Interests:
none
E. O. Zvyagina
Tula State University
Russian Federation
Competing Interests:
Russian Federation
Boldina str., 128, Tula, 300028
Competing Interests:
none
E. V. Reznik
Pirogov Russian National Research Medical University; Savelyeva City Clinical Hospital № 31
Russian Federation
Competing Interests:
Russian Federation
Lobachevsky str., 42, Moscow, 119415
Competing Interests:
none
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What is already known about the subject?
- Cardiac fatty acid binding protein (cFABP) has been extensively studied as an early diagnostic and prognostic marker for myocardial infarction.
- For use in acute heart failure (AHF), data on the marker’s diagnostic and prognostic value are conflicting.
What might this study add?
- cFABP is associated with higher mortality in patients with Killip class III-IV AHF in the short and long term.
How might this impact on clinical practice?
- cFABP determination using high-quality assays will help quickly assess patients’ prognosis, unlike other standard laboratory markers routinely assessed in AHF.
Review
For citations:
Bychkova M.S., Zvyagina E.O., Reznik E.V. Fatty acid binding protein as a prognostic indicator in patients with acute heart failure. Russian Journal of Cardiology. 2026;31(5):6808. (In Russ.) https://doi.org/10.15829/1560-4071-2026-6808. EDN: NTIYNE
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