A new look at the myocardial fibrosis: "cold" and "hot" phenotypes. Pathogenesis features and potential therapeutic strategies
Natalia A. Dragomiretskaya,
Ivan I. Volchkov,
Andrey K. Belov,
Liliya A. Gontsova,
Maria V. Vetluzhskaya,
Valery I. Podzolkov Abstract
Fibrosis is a process characterized by excessive accumulation of extracellular matrix components in response to injury, ischemia, and chronic metabolic and immune inflammation. Normally, extracellular matrix homeostasis is regulated by maintaining a balance between the intensity of fibrogenesis and fibrolysis. In this review, for the first time in the Russian literature, a new concept of "cold" and "hot" fibrosis is highlighted, based on the peculiarities of the interaction of the extracellular matrix and the immune system. The role of biologically active substances acting as candidate biomarkers for fibrosis and antifibrotic response is discussed. The development of such a biomarker concept can be considered as a basis for the creation of antifibrotic therapy strategies relevant for the treatment of various cardiac diseases.
About the Authors
Natalia A. Dragomiretskaya
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Russian Federation
Russian Federation
Ivan I. Volchkov
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Russian Federation
Russian Federation
Andrey K. Belov
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Russian Federation
Russian Federation
Liliya A. Gontsova
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Russian Federation
Russian Federation
Maria V. Vetluzhskaya
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Russian Federation
Russian Federation
Valery I. Podzolkov
ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)
Russian Federation
Russian Federation
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Dragomiretskaya N.A., Volchkov I.I., Belov A.K., Gontsova L.A., Vetluzhskaya M.V., Podzolkov V.I. A new look at the myocardial fibrosis: "cold" and "hot" phenotypes. Pathogenesis features and potential therapeutic strategies. Russian Journal of Cardiology. :6397. (In Russ.)
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