CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS
https://doi.org/10.15829/1560-4071-2016-1-41-46
Abstract
Aim. Study of toxic effect of anthracycline anibiotics on the heart in various periods of application.
Material and methods. We studied 94 patients with lymphomas before, at the moment and in long-term follow-up of chemotherapy. All patients underwent AHM with HRV and QTc duration. In EchoCG we studied systolic and diastolic LV function; the latter — with values of V1/3, IF and RF in the first third of diastole.
Results. In some patients at the moment of anthracycline application we found the prolonged QTc with statistically lower HRV and diastolic parameters (IF and RF of LV). In 11 from 24 patients, assessed in dynamics, we found the signs of CHF, followed with consequent decrease of EDV, iEDV amd RF of LV.
Conclusion. In some patients at the moment of anthracycline antibiotics load there is covert diastolic dysfunction of the LV and predominance of SNS on the heart that might lead later to remodeling of myocardium with the development of anthracyclineinduced cardiomyopathy.
About the Authors
K. V. Shuykova
N. I. P irogov Russian National Research Medical University (RNRMU), Moscow, Russia
Russian Federation
Russian Federation
E. I. Emelina
N. I. P irogov Russian National Research Medical University (RNRMU), Moscow, Russia
Russian Federation
Russian Federation
G. E. Gendlin
N. I. P irogov Russian National Research Medical University (RNRMU), Moscow, Russia
Russian Federation
Russian Federation
G. I. Storojakov
N. I. P irogov Russian National Research Medical University (RNRMU), Moscow, Russia
Russian Federation
Russian Federation
References
1. Stewart B, Wild CP. World Cancer Report 2014. http://globocan.iarc.fr/Default.aspx.
2. Kaprin AD, Starinskiy VV, Petrova GV. Malignant neoplasms in Russia in 2012 (morbidity and mortality). M.: FGBI “MNIOI them. P. A. Herzen “Russian Ministry of Health; 2014. Russian (Каприн А. Д., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России в 2012 году (заболеваемость и смертность). М.: ФГБУ “МНИОИ им. П . А. Герцена” Минздрава России; 2014).
3. Raj S, Franco VI, Lipshultz SE. Anthracycline-Induced Cardiotoxicity: A Review of Pathophysiology, Diagnosis, and Treatment. Curr Treat Options Cardio Med (2014) 16: 315.
4. Curigliano G, Cardinale D, Suter T, et al. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines. Annals of Oncology. 2012. 23 (Suppl 7): vii155-vii166.
5. Gendlin GE, Storozhakov GI, Shuykova KV, et al. Acute cardiovascular events during antitumor drugs treatment: clinical cases. Clinical oncohematology. 2011; 4(2): 155-64
6. Russian (Гендлин Г. Е., Сторожаков Г. И., Шуйкова К . В. и др. Острые сердечно-сосудистые события во время применения противоопухолевых химиопрепаратов: клинические наблюдения. Клиническая онкогематология. 2011; 4 (2): 155-64).
7. Douraid KS, Kakil IR. Chemotherapy Induced Cardiomyopathy: Pathogenesis, Monitoring and Management. J. Clin. Med Res. 2009; 1(1): 8-12.
8. Emelina EI. The cardiovascular system in patients lymphoproliferative diseases treated with anthracycline antibiotics. Dissertations for the degree of candidate of medical sciences. Moscow. 2007. (Емелина Е. И. Состояние сердечно-сосудистой системы у больных лимфопролиферативными заболеваниями, получавших антрациклиновые антибиотики. Дисс. на соискание ученой степени кандидата медицинских наук. Москва. 2007).
9. Satlykova DF. Role of radionuclide 4D-tomoventriculography in a comprehensive assessment of violations of systolic and diastolic function of the heart in patients with heart failure with preserved and reduced left ventricular ejection fraction. Dissertations for the degree of candidate of medical sciences. Moscow. 2014. (Сатлыкова Д. Ф. Роль радионуклидной 4D-томовентрикулографии в комплексной оценке нарушений систолической и диастолической функции сердца у пациентов с сердечной недостаточностью с сохраненной и сниженной фракцией выброса левого желудочка. Диссертация на соискание ученой степени кандидата медицинских наук. Москва. 2014).
10. Iskhakov ID. Radiation diagnostics and monitoring of mediastinal tumor and cytostatic cardiomyopathy at lymphogranulomatosis and lymphosarcoma. Abstract of dissertation for the degree of candidate of medical sciences. Moscow. 2005. (Исхаков И. Д. Лучевая диагностика и мониторинг опухоли средостения и цитостатической кардиопатии при лимфогранулематозе и лимфосаркомах. Автореферат диссертации на соискание ученой степени кандидата медицинских наук. Москва. 2005).
11. Kalinkina NV. Interconnection of painless myocardial ischemia and heart rate variability in patients receiving cumulative doses of anthracyclines small. Ukrainian therapeutic journal. 2006; 4: 27-30. (Калинкина Н. В. Взаимосвязь безболевой ишемии миокарда и вариабельности сердечного ритма у пациентов, получивших малые кумулятивные дозы антрациклинов. Украинский терапевтический журнал. 2006; 4: 27-30).
12. Horacek JM, Jakl M, Horackova J, et al. Assessment of anthracycline-induced cardiotoxicity with electrocardiography. Exp Oncol. 2009. 31(2): 115-7.
13. Wasielewski M, van Spaendonck-Zwarts KY, Westerink ND, et al. Potential genetic predisposition for anthracycline-associated cardiomyopathy in families withdilated cardiomyopathy. Open Heart. 2014. 18; 1(1): e000116
Review
For citations:
Shuykova K.V., Emelina E.I., Gendlin G.E., Storojakov G.I. CHANGE OF THE LEFT VENTRICLE FUNCTIONING IN LYMPHOMA TREATED WITH ANTHRACYCLINE ANTIBIOTICS. Russian Journal of Cardiology. 2016;(1):41-46. (In Russ.) https://doi.org/10.15829/1560-4071-2016-1-41-46
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