Risk factors for coronary artery tortuosity: an original study
A. R. Yenikeeva,
I. V. Buzaev,
E. A. Badykova,
I. A. Lakman,
Yu. O. Iskhakova,
A. T. Bikmeev,
A. A. Ilyina,
E. I. Khudoyberdiev,
N. Sh. Zagidullin https://doi.org/10.15829/1560-4071-2025-6045
EDN: NUGPBI
Abstract
Aim. To study the relationship between hypertension (HTN) and coronary artery tortuosity (CAT), as well as to determine the predictors of coronary artery tortuosity (CAT).
Material and methods. In this retrospective, non-randomized, uncontrolled study, 296 patients with coronary artery disease were examined, including 148 with and 148 without CAT according to coronary angiography.
Results. CAT in patients correlated with the age of manifestation — 0,154 (p=0,008) and the duration of HTN — 0,148 (p=0,011). Logistic regression revealed the following factors influencing CAT: age of HTN manifestation (odds ratio (OR) 4,9, 95% confidence interval (CI): 1,4-20,3), body mass index (OR 4,3, 95% CI: 1,8-11,4), HTN duration (OR 4,4, 95% CI: 2,0-9,9), diabetes/impaired glucose tolerance (OR 4,6, 95% CI: 1,1-19,5) and a prior myocardial infarction (OR 3,1, 95% CI: 1,3-8,7).
Conclusion. The duration and age of HTN manifestation correlated with CAT presence, while age, body mass index, diabetes, and myocardial infarction were risk factors for tortuosity development.
About the Authors
A. R. Yenikeeva
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
I. V. Buzaev
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
E. A. Badykova
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
I. A. Lakman
Ufa University of Science and Technology
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
Yu. O. Iskhakova
Ufa University of Science and Technology
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
A. T. Bikmeev
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
A. A. Ilyina
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
E. I. Khudoyberdiev
Bashkir State Medical University
Tajikistan
Competing Interests:
Tajikistan
Ufa
Competing Interests:
None
N. Sh. Zagidullin
Bashkir State Medical University
Russian Federation
Competing Interests:
Russian Federation
Ufa
Competing Interests:
None
References
1. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953-2041. doi:10.1093/eurheartj/ehy686.
2. Muromtseva GA, Kontsevaya AV, Konstantinov VV, et al. The prevalence of non-infectious diseases risk factors in russian population in 2012-2013 years. The results of ESSE-RF. Cardiovascular Therapy and Prevention. 2014;13(6):4-11. (In Russ.) doi:10.15829/1728-8800-2014-6-4-11.
3. Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. The lancet. 2005;365(9455):217-23. doi:10.1016/S0140-6736(05)-17741-1.
4. Ciurică S, Lopez-Sublet M, Loeys BL, et al. Arterial tortuosity: novel implications for an old phenotype. Hypertension. 2019;73(5):951-60. doi:10.1161/HYPERTENSIONAHA.118.11647.
5. Eleid MF, Guddeti RR, Tweet MS, et al. Coronary artery tortuosity in spontaneous coronary artery dissection: angiographic characteristics and clinical implications. Circulation: Cardiovascular Interventions. 2014;7(5):656-62. doi:10.1161/CIRCINTERVENTIONS.114.001676.
6. Yurdam F, Kış M, Demir Yu, et al. Predictors of coronary tortuosity in patients with chronic coronary syndrome. Kardiologiia. 2023;63(8):56-61. (In Russ.) doi:10.18087/cardio.2023.8.n2485.
7. Tutunnik EI. Mathematical methods in psychology: study-methodological guidelines. Electron. Spb: SPbGIPSR, 2012; 172 p. (In Russ.)
8. Jiang L, Yang Z, Wang D, et al. Diabetes prediction model for unbalanced community follow-up data set based on optimal feature selection and scorecard. Digital Health. 2024;10:20552076241236370. doi:10.1177/20552076241236370.
9. Edlitz Y, Segal E. Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards. Elife. 2022;11: e71862. doi:10.7554/eLife.71862.
10. Konigstein M, Ben-Yehuda O, Redfors B, et al. Impact of Coronary Artery Tortuosity on Outcomes Following Stenting: A Pooled Analysis From 6 Trials. JACC Cardiovasc Interv. 2021;14(9):1009-18. doi:10.1016/j.jcin.2020.12.027.
11. Huang H, Fu JJ, Yao PG, et al. Age and duration of hypertension are associated with carotid artery tortuosity. Frontiers in Neurology. 2024;15:1307984. doi:10.3389/fneur.2024.1307984.
12. Tapp RJ, Owen CG, Barman SA, et al. Associations of Retinal Microvascular Diameters and Tortuosity With Blood Pressure and Arterial Stiffness: United Kingdom Biobank. Hypertension. 2019;74(6):1383-90. doi:10.1161/HYPERTENSIONAHA.119.13752.
13. Groves SS, Jain AC, Warden BE, et al. Severe coronary tortuosity and the relationship to significant coronary artery disease. West Virginia Medical Journal. 2009;105(4):14-8.
14. Kahe F, Sharfaei S, Pitliya A, et al. Coronary artery tortuosity: a narrative review. Coronary artery disease. 2020;31(2):187-92. doi:10.1097/MCA.0000000000000769.
15. Hanboly NH, Ghany MMA, El-Kaffas SMH, Ahmed TU. Prevalence, risk factors, and coronary angiographic profile in patients with tortuous coronary artery. Cor Vasa. 2021;63:547-54. doi:10.33678/cor.2021.057.
16. Chiha J, Mitchell P, Gopinath B, et al. Gender differences in the prevalence of coronary artery tortuosity and its association with coronary artery disease. IJC Heart Vasc. 2017;14:23-7. doi:10.1016/j.ijcha.2016.11.005.
17. Elamragy A, Yakoub S, AbdelGhany M, Ammar W. Coronary tortuosity relation with carotid intima-media thickness, coronary artery disease risk factors, and diastolic dysfunction: is it a marker of early atherosclerosis? The Egyptian Heart Journal. 2021;73:1-9. doi:10.1186/s43044-021-00157-6.
Supplementary files
- Coronary artery tortuosity may indicate concomitant vasculopathy and microvascular ischemia.
- Coronary artery tortuosity correlated with the time of hypertension manifestation.
- The risk factors for coronary artery tortuosity were age, body mass index, diabetes/impaired glucose tolerance, and prior myocardial infarction.
Review
For citations:
Yenikeeva A.R., Buzaev I.V., Badykova E.A., Lakman I.A., Iskhakova Yu.O., Bikmeev A.T., Ilyina A.A., Khudoyberdiev E.I., Zagidullin N.Sh. Risk factors for coronary artery tortuosity: an original study. Russian Journal of Cardiology. 2025;30(6):6045. (In Russ.) https://doi.org/10.15829/1560-4071-2025-6045. EDN: NUGPBI
Views:
24
Email this article 