SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE
https://doi.org/10.15829/1560-4071-2014-4-ENG-22-27
Abstract
Aim. This work aims to study the safety of tirofiban alone and in combination with various treatments in acute ischemic stroke (AIS).
Material and methods. 120 AIS patients were included in this study. There were 3 groups as below: Group A (tirofiban alone, n=68), Group B (tirofiban plus thrombolytic therapy, n=26), and Group C (tirofiban plus bridging therapy, n=26). Risk factors, stroke severity, initial imaging, treatment regimens, complications and longterm outcomes were analyzed.
Results. Eight patients (6,7%) in Group A, 6 patients (23,1%) in Group B and 2 patients (7,7%) in Group C had hemorrhage during or after treatment. Sixteen patients (6 in Group A, 8 in Group B and 2 in Group C) died during hospital admission. The mortality rate was 13,3% (8,8% for Group A, 30,7% for Group B and 7,7% for Group C, respectively) in the acute phase. A favorable outcome (mRS 0–2) at the first three months after stroke was only observed in 43,3% of patients (44,1% in Group A, 46,7% in Group B and 36,4% in Group C). The average Barthel index was 72,3 in Group A, 84,4 in Group B and 56,8 in Group C (total score: 71,0).
Conclusion. The stroke treatment with tirofiban is safe in AIS. A large randomized controlled trial in the future will be needed to decrease the minor bleeding complication of tirofiban therapy.
About the Authors
Yan-Jun Zhang
Department of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, China
Department of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou 450003, China. Tel: 86–0371–67077323
Qing Liu
Department of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, China
Qin Zhan
Department of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, China
Qiong Li
Department of Geriatrics, People’s Hospital of Zhengzhou, Zhengzhou, China
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Review
For citations:
Zhang Ya., Liu Q., Zhan Q., Li Q. SAFETY OF TIROFIBAN FOR PATIENTS WITH ACUTE ISCHEMIC STROKE IN ROUTINE CLINICAL PRACTICE. Russian Journal of Cardiology. 2014;(4-ENG):22-27. https://doi.org/10.15829/1560-4071-2014-4-ENG-22-27
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