T-cell immune response in initiation, progression, and destabilization of atherosclerosis: a review
https://doi.org/10.15829/1560-4071-2024-6017
Abstract
A detailed characterization of the diversity, clonality, and antigen specificity of the T-cell repertoire contributes to the understanding of the adaptive immune response role in a wide range of diseases, including arteriosclerosis. This article discusses the differentiation of T-lymphocytes and the factors leading to their activation in atherosclerosis. Furthermore, the article discusses the data obtained during the analysis of T-cell repertoires in carotid and coronary artery atherosclerosis using new sequencing technologies, such as single-cell sequencing. The importance and peculiarity of studying the diversity of T-lymphocyte subphenotypes, their antigenic specificity, and their interaction with other cells in atherosclerosis are emphasized. The aim of this review was to synthesize data from studies examining the T-cell immune response in atherosclerosis, utilizing T-cell receptor sequencing techniques, including those based on single-cell sequencing technology.
About the Authors
M. S. Nazarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
Tomsk
A. A. Sleptsov
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Russian Federation
Tomsk
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk National Research Medical Center; Siberian State Medical University
Russian Federation
Russian Federation
Tomsk
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Supplementary files
- Modern sequencing technologies, especially those performed using single-cell technology, make it possible to reveal the features of T-cell immune response subphenotypes in atherosclerosis.
- Clonal expansion and autoreactivation of T-cells play an important role in atherosclerosis initiation and progression.
- Understanding the spatial diversity of T-cell subphenotypes, their antigen specificity and immune interactions within atherosclerotic plaques using innovative experimental and bioinformatic approaches is critical for translating knowledge into clinical practice and developing effective treatments.
Review
For citations:
Nazarenko M.S., Sleptsov A.A., Puzyrev V.P. T-cell immune response in initiation, progression, and destabilization of atherosclerosis: a review. Russian Journal of Cardiology. 2024;29(11S):6017. (In Russ.) https://doi.org/10.15829/1560-4071-2024-6017
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