The influence of genetic characteristics on psychological readaptation after myocardial infarction: a review
https://doi.org/10.15829/1560-4071-2024-5979
Abstract
Pathological personality traits (anxiety, depressive, hypochondriacal) significantly worsen the treatment and rehabilitation of patients with acute myocardial infarction. The aim of the work was to study the influence of genetic characteristics of patients on psychological readaptation in patients with acute coronary pathology. The review lists the identified candidate genes that affect the depression occurrence in these patients and represent potential targets for therapeutic intervention. Nucleotide sequence variants associated with a poor response to antidepressants in this category of patients are discussed. The use of genetic methods in examination, further consideration of the individual characteristics of each patient when choosing therapy, prescribing a rehabilitation course will allow for an individual approach to each patient, which in turn should improve the prognosis of the disease.
About the Authors
S E. Golovenkin
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Krasnoyarsk
S. Yu. Nikulina
Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Krasnoyarsk
M. G. Bubnova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Moscow
V. N. Maksimov
Research Institute for Therapy and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and Genetics
Russian Federation
Russian Federation
Novosibirsk
References
1. 2020 Clinical practice guidelines for Acute ST-segment elevation myocardial infarction. Russian Journal of Cardiology. 2020;25(11):4103. (In Russ.).
2. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Russian Journal of Cardiology. 2021; 26(3):4418. (In Russ.).
3. Acute myocardial infarction with ST segment elevation electrocardiograms: rehabilitation and secondary prevention. Russian clinical guidelines. CardioSomatica. 2014;(S1): 5-41. (In Russ.).
4. Cardiac rehabilitation and secondary prevention. Edited by D.M. Aronov. - Moscow: GEOTAR-Меdia, 2021. - 464c. (In Russ.).
5. Nonka TG, Lebedeva EV, Repin AN. Clinical features of coronary artery disease and 5-year survival of patients after myocardial infarction against the background of depressive disorders. Terapevticheskii arkhiv. 2024;96(1):17-21. (In Russ.).
6. Ambrosetti M, Abreu A, Corra U, et al. Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Eur J Prev Cardiol. 2021;28(5):460-495. doi:10.1177/2047487320913379.
7. Zateyshchikov DA, Favorova OO, Chumakova OS. Molecular cardiology: from decoding the genetic nature and mechanisms of the diseases development to the introduction into the clinic. Terapevticheskii Arkhiv. 2022;94(4):463-6. (In Russ.).
8. Meshkov AN, Kiseleva AV, Ershova AI, et al. ANGPTL3, ANGPTL4, APOA5, APOB, APOC2, APOC3, LDLR, PCSK9, LPL gene variants and coronary artery disease risk. Russian Journal of Cardiology. 2022;27(10):5232. (In Russ.).
9. Nalesnik EO, Muslimova EF, Afanasiev SA, et al. Association of ACE gene polymorphisms with cardiovascular events in patients after elective percutaneous coronary interventions. Russian Journal of Cardiology. 2022;27(10):4968.
10. Yakhontov DA, Ostanina YuO, Kononchuk VV, et al. MicroRNA level in patients with stable coronary artery disease with borderline coronary artery stenosis. Russian Journal of Cardiology. 2022;27(10):5224.
11. Lebedeva EV, Sergienko TN, Nonka TG, et al. Psychotherapeutic aspects of work in the practice of a cardiologist in preparing patients with coronary artery disease for coronary bypass surgery. Siberian Bulletin of Psychiatry and Narcology. 2017;(2):81-90. (In Russ.).
12. Lebedeva EV, Gutkevich EV, Ivanova SA, et al. The phenomenon of comorbidity of depression and coronary disease in the light of modern advances in genetics (literature review). Siberian Bulletin of Psychiatry and Narcology. 2012;(6):41-7. (In Russ.).
13. Lozhkina NG, Tolmacheva AA, Khasanova MX, et al. Genetic predictors of five-year outcomes of acute coronary syndrome. Russian Journal of Cardiology. 2019;(10):86-90. (In Russ.).
14. Ponasenko AV, Tsepokina AV, Khutornaya MV, et al. Interleukin 18 levels in patients with stable coronary artery disease is associated with IL18RAP and IL18R1 gene polymorphism and the risk of myocardial infarction. Russian Journal of Cardiology. 2020;25(10):3977. (In Russ.).
15. Brazhnik VА, Minushkina LO, Averkova АО, et al. Polymorphism of TNF gene in acute coronary syndrome patients: data from the registries ORACLE I and ORACLE II. Russian Journal of Cardiology. 2018;(10):22-7. (In Russ.).
16. Golimbet VE, Volel BA, Kopilov FY, et al. Anxiety and polymorphism Val66Met the gene BDNF - predictors of depression severity in coronary heart disease. Cardiologiia. 2015;55(1):9-13. (In Russ.).
17. Belyalov FI. Depression, anxiety and stress in patients with coronary heart disease. Terapevticheskii Arkhiv. 2017;8:104-9. (In Russ.).
18. Sumin AN, Sheglova AV, Anchkova MI, et al. Clinical and psychological associations and coping strategies for personality type D and depression in patients with coronary heart disease. Siberian Journal of Clinical and Experimental Medicine. 2024;39(1):65-74. (In Russ.).
19. Grazhdan IK, Kopilov FY, Barskiy VI, et al. The relationship of genotypes 5-HT2A (а-1438G) of receptors with the onset of coronary heart disease and personal anxiety. Cardiology and Cardiovascular Surgery. 2016;9(1):58-68. (In Russ.).
20. Golimbet VE, Volel BA, Korovaiceva GI, et al. The association of inflammatory factor genes with neuroticism, anxiety and depression in men with coronary heart disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(3):74-9. (In Russ.).
21. Carmin CN, Ownby RL, Fontanella C, et al. Impact of Mental Health Treatment on Outcomes in Patients With Heart Failure and Ischemic Heart Disease. J Am Heart Assoc. 2024;13(7):e031117. doi:10.1161/JAHA.123.031117.
22. Greden JF, Parikh SV, Rothschild AJ, et al. Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and raterblinded, randomized, controlled study. J Psychiatr Res. 2019;111:59-67. doi:10.1016/j.jpsychires.2019.01.003.
23. Benitez J, Cool CL, Scotti DJ. Use of combinatorial pharmacogenomic guidance in treating psychiatric disorders. Per Med. 2018;15(6):481-94. doi:10.2217/pme-2018-0074.
24. Lu Y, Wang Z, Georgakis MK, et al. Genetic Liability to Depression and Risk of Coronary Artery Disease, Myocardial Infarction, and Other Cardiovascular Outcomes. J Am Heart Assoc. 2021;10(1):e017986. doi:10.1161/JAHA.120.017986.
25. Nakatani D, Sato H, Sakata Y, et al.; Osaka Acute Coronary Insufficiency Study Group. Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. Am Heart J. 2005;150(4):652-8. doi:10.1016/j.ahj.2005.03.062.
26. Kangelaris KN, Vittinghoff E, Otte C, et al. Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. J Gen Intern Med. 2010;25(10):1030-7. doi:10.1007/s11606-010-1403-0.
27. Kang HJ, Bae KY, Kim SW, et al. Relationship between interleukin-1β and depressive disorder after acute coronary syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2017;72:55-9. doi:10.1016/j.pnpbp.2016.09.001.
28. Kim JM, Stewart R, Kang HJ, et al. Serotonergic genes and depressive disorder in acute coronary syndrome: The Korean depression in ACS (K-DEPACS) study. Eur Neuropsychopharmacol. 2015;25(6):882-8. doi:10.1016/j.euroneuro.2015.02.006.
29. Garrels E, Kainth T, Silva B, et al. Pathophysiological mechanisms of post-myocardial infarction depression: a narrative review. Front Psychiatry. 2023;14:1225794. doi:10.3389/fpsyt.2023.1225794.
30. Popp S, Schmitt-Böhrer A, Langer S, et al. 5-HTT Deficiency in Male Mice Affects Healing and Behavior after Myocardial Infarction. J Clin Med. 2021;10(14):3104. doi:10.3390/jcm10143104.
31. Golimbet VE, Volel' BA, Dolzhikov AV, et al. Association of 5-HTR2A and 5-HTR2C serotonin receptor gene polymorphisms with depression risk in patients with coronary heart disease. Bull Exp Biol Med. 2014;156(5):680-3. doi:10.1007/s10517-014-2424-1.
32. Brandt J, Warnke K, Jörgens S, et al. Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study. J Neural Transm (Vienna). 2020;127(12):1651-62. doi:10.1007/s00702-020-02243-6.
33. Gonzales TK, Yonker JA, Chang V, et al. Myocardial infarction in the Wisconsin Longitudinal Study: the interaction among environmental, health, social, behavioural and genetic factors. BMJ Open. 2017;7(1):e011529. doi:10.1136/bmjopen-2016-011529.
34. Chen M, Wang Z, Xu H, et al. Genetics of mood instability and risk of cardiovascular diseases: A univariable and multivariable Mendelian randomization study. J Affect Disord. 2024;347:406-13. doi:10.1016/j.jad.2023.11.052.
35. Dai Z, Li Q, Yang G, et al. Using literature-based discovery to identify candidate genes for the interaction between myocardial infarction and depression. BMC Med Genet. 2019;20(1):104. doi:10.1186/s12881-019-0841-8.
36. Li GH, Cheung CL, Chung AK, et al. Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study. Psychol Med. 2022;52(9):1765-76. doi:10.1017/S0033291720003566.
37. McCaffery JM, Duan QL, Frasure-Smith N, et al. Genetic predictors of depressive symptoms in cardiac patients. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(3): 381-8. doi:10.1002/ajmg.b.30824.
38. Yanchen Zhu, Zhengbo Wu, Yahui Wang, et al. Role of Blood Lipids in the Shared Genetic Etiology Between Major Depressive Disorder and Myocardial Infarction: A Large-scale Multi-trait Association Analysis medRxiv 2024.04.08.24305481. doi:10.1101/2024.04.08.24305481.
39. Wang M, Cheng L, Gao Z, et al. Investigation of the shared molecular mechanisms and hub genes between myocardial infarction and depression. Front Cardiovasc Med. 2023;10:1203168. doi:10.3389/fcvm.2023.1203168.
40. Peng B, Meng H, Guo L, et al. Anxiety disorder and cardiovascular disease: a twosample Mendelian randomization study. ESC Heart Fail. 2024;11(2):1174-81. doi:10.1002/ehf2.14676.
41. Dhaibar HA, Kamberov L, Carroll NG, et al. Exposure to Stress Alters Cardiac Gene Expression and Exacerbates Myocardial Ischemic Injury in the Female Murine Heart. Int J Mol Sci. 2023;24(13):10994. doi:10.3390/ijms241310994.
42. Zhang F, Cao H, Baranova A.Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases. Front Cardiovasc Med. 2021; 8:735136. doi:10.3389/fcvm.2021.735136.
43. Frey A, Popp S, Post A, et al. Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain. Front Behav Neurosci. 2014;8:376. doi:10.3389/fnbeh.2014.00376.
44. Amare AT, Schubert KO, Tekola-Ayele F, et al. The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression. J Neural Transm (Vienna). 2019;126(1):35-45. doi:10.1007/s00702-018-01966-x.
Supplementary files
- Molecular genetic analysis has enabled the identification of mechanisms underlying pathological changes resulting from various diseases.
- The article discusses issues related to the influence of candidate genes on the occurrence of depression in patients with acute myocardial infarction, as well as considers potential targets for therapeutic intervention and lists variants of the nucleotide sequence associated with a poor response to antidepressants in this category of patients.
- The assessment of the patient's individual characteristics derived from genetic analysis helps to implement the personalized approach to therapy and rehabilitation in acute myocardial infarction.
Review
For citations:
Golovenkin S.E., Nikulina S.Yu., Bubnova M.G., Maksimov V.N. The influence of genetic characteristics on psychological readaptation after myocardial infarction: a review. Russian Journal of Cardiology. 2024;29(11S):5979. (In Russ.) https://doi.org/10.15829/1560-4071-2024-5979
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