Efficiency of physical rehabilitation of patients with heart failure after myocardial infarction
https://doi.org/10.15829/1560-4071-2025-5950
EDN: MGSEBV
Abstract
Aim. To study the effectiveness of a 6-month training program in patients with New York Heart Association (NYHA) class II-III heart failure (HF) after myocardial infarction (MI).
Material and methods. Patients (n=40) with left ventricular (LV) ejection fraction (EF) <45% after MI were included. Patients were randomized into the main group (n=20) with training and drug therapy and the control group (n=20) with therapy only. Training program and follow-up lasted 6 months.
Results. According to the bicycle ergometry after 6 months, the main group patients demonstrated a significant increase in the intensity (by 16,4%, p<0,01) and duration (by 21,3%, p<0,01) of physical activity (PA) against a decrease in these parameters in patients of control group (by 13,9%, p<0,01 and 20,4%, p<0,01, respectively). Only in the trained patients, LVEF increased after 6 months (by 6,5%, p=0,03) versus decrease (by 8,6%, p=0,024) in the control group. Systemic vascular resistance (SVR) against the background of physical training after 6 months decreased by 180±64 dyn·s·cm−5 (p=0,001) and did not change in the control group. Minnesota Living with Heart Failure Questionnaire parameters improved after 6 months with PA (by 28,4±3,8%, p=0,001) and worsened without it (by 26,9±3,6%, p=0,001). With the training program, there was a decrease in the number of angina attacks (by 31,1%, p=0,022), complaints of dyspnea (by 15%, p=0,044) and muscle fatigue (by 21,6%, p=0,039). In the control group, these indicators did not change.
Conclusion. The 6-month training program for patients with NYHA class II-III HF contributed to a decrease in the severity of clinical symptoms, improved tolerance to PT, echocardiography parameters and quality of life. It is advisable to involve patients with HF and reduced LVEF in cardiac rehabilitation programs based on physical training.
About the Authors
D. M. AronovRussian Federation
David M. Aronov - MD, PhD, Professor; chief scientific researcher of department of rehabilitation and secondary prevention for Cardiovascular Disease.
Moscow
Competing Interests:
None
M. G. Bubnova
Russian Federation
Marina G. Bubnova - MD, PhD, Professor; head of department of rehabilitation and secondary prevention for Cardiovascular Disease.
Moscow
Competing Interests:
None
References
1. Savarese G, Becher PM, Lund LH, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272-87. doi:10.1093/cvr/cvac013.
2. Polyakov DS, Fomin IV, Belenkov YuN, et al. Chronic heart failure in the Russian Federation: what has changed over 20 years of follow-up? Results of the EPOCH-CHF study. Kardiologiia. 2021;61(4):4-14. (In Russ.) doi:10.18087/cardio.2021.4.n1628.
3. Shlyakhto EV, Belenkov YuN, Boytsov SA, et al. Interim analysis of a prospective observational multicenter registry study of patients with chronic heart failure in the Russian Federation "PRIORITETCHF": initial characteristics and treatment of the first included patients. Russian Journal of Cardiology. 2023;28(10):5593. (In Russ.) doi:10.15829/1560-4071-2023-5593. EDN AMDHTV.
4. Drapkina OM, Boytsov SA, Omelyanovskiy VV, et al. Socio-economic impact of heart failure in Russia. Russian Journal of Cardiology. 2021;26(6):4490. (In Russ.) doi:10.15829/1560-4071-2021-4490.
5. van den Berge JC, van Vark LC, Postmus D, et al. Determinants of quality of life in acute heart failure patients with and without comorbidities: a prospective, observational study. Eur J Cardiovascular Nursing. 2022;21:205-12. doi:10.1093/eurjcn/zvab061.
6. Keteyian SJ, Patel M, Kraus WE, et al. Variables measured during cardiopulmonary exercise testing as predictors of mortality in chronic systolic heart failure. J Am Coll Cardiol. 2016;67:780-9. doi:10.1016/j.jacc.2015.11.050.
7. McDonagh TA, Metra M, Adamo M, et al. ESC Scientific Document Group. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599-726. doi:10.1093/eurheartj/ehab368.
8. Buono MGD, Arena R, Borlaug BA, et al. Exercise Intolerance in Patients With Heart Failure. J Am Coll Cardiol. 2019;73:2209-25.
9. Piepoli MF, Crisafulli A. Pathophysiology of human heart failure: importance of skeletal muscle myopathy and reflexes. Experimental Physiology. 2014;99(4):609-15. doi:10.1113/expphysiol.2013.074310.
10. Aimo A, Saccaro LF, Borrelli C, et al. The ergoreflex: how the skeletal muscle modulates ventilation and cardiovascular function in health and disease. Eur J Heart Failure. 2021;23:1458-67. doi:10.1002/ejhf.2298.
11. Passantin A, Vecchia LAD, Corrà U, et al. The Future of Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure. Front. Cardiovasc. Med. 2021;8:709898. doi:10.3389/fcvm.2021.709898.
12. van Tol BAF, Huijsmans RJ, Kroon DW, et al. Effects of exercise training on cardiac performance, exercise capacity and quality of life in patients with heart failure: A meta-analysis. Eur J Heart Failure. 2006;8:841-50. doi:10.1016/j.ejheart.2006.02.013.
13. Taylor RS, Walker S, Smart NA, et al. ExTraMATCH II Collaboration. Impact of exercise rehabilitation on exercise capacity and quality-of-life in heart failure: individual participant meta-analysis. J Am Coll Cardiol. 2019;73:1430-43. doi:10.1016/j.jacc.2018.12.072.
14. Sagar VA, Davies EJ, Briscoe S, et al. Exercise-based rehabilitation for heart failure: systematic review and meta-analysis. Open Heart. 2015;2(1):e000163. doi:10.1136/openhrt-2014-00016.
15. Tegegne TK, Rawstorn JC, Nourse RA, et al. Effects of exercise-based cardiac rehabilitation delivery modes on exercise capacity and health-related quality of life in heart failure: a systematic review and network meta-analysis. Open Heart. 2022;9:e001949. doi:10.1136/openhrt-2021-001949.
16. Antunes-Correa LM, Nobre TS, Groehs RV, et al. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. Am J Physiol Heart Circ Physiol. 2014;307:1655-66. doi:10.1152/ajpheart.00136.2014.
17. Lelyavina TA, Sitnikova MYu, Galenko VL, et al. The role of muscle tissue in the pathogenesis of chronic heart failure — the potential of exposure (FORMA study). Russian Journal of Cardiology. 2019;(10):58-65. (In Russ.) doi:10.15829/1560-4071-2019-10-58-65.
18. Tucker WJ, Beaudry RI, Liang Y, et al. Metaanalysis of exercise training on left ventricular ejection fraction in heart failure with reduced ejection fraction: a 10-year update. Prog Cardiovasc Dis. 2019;62:163-71. doi:10.1016/j.pcad.2018.08.006.
19. Bozkurt B, Fonarow GC, Goldberg LR, et al. Cardiac Rehabilitation for Patients With Heart Failure. JACC Expert Panel. J Am Coll Cardiol. 2021;77:1454-69. doi:10.1016/j.jacc.2021.01.030.
20. Taylor RS, Walker S, Smart NA, et al. ExTraMATCH II Collaboration. Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials. Eur J Heart Fail. 2018;20:1735-43. doi:10.1002/ejhf.1311.
21. Flynn KE, Pina IL, Whellan DJ, et al., HF-ACTION Investigators. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301:1451-9. doi:10.1001/jama.2009.457.
22. Sabbag A, Mazin I, Rott D, et al. The prognostic significance of improvement in exercise capacity in heart failure patients who participate in cardiac rehabilitation programme. Eur J Prev Cardiol. 2018;25:354-61. doi:10.1177/2047487317750427.
Supplementary files
- The development of heart failure (CHF) after myocardial infarction significantly worsens exercise tolerance, quality of life and survival of patients.
- The prognosis of patients with HF is one of the most unfavorable, despite the introduction of effective treatment methods into practice.
- Involvement of patients with HF in cardiac rehabilitation programs based on physical training leads to an increase in exercise tolerance, improvement of clinical symptoms and quality of life after 3 months with an effect increase after 6 months.
Review
For citations:
Aronov D.M., Bubnova M.G. Efficiency of physical rehabilitation of patients with heart failure after myocardial infarction. Russian Journal of Cardiology. 2025;30(1):5950. (In Russ.) https://doi.org/10.15829/1560-4071-2025-5950. EDN: MGSEBV