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Российский кардиологический журнал

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ЭФФЕКТ ВОЗДЕЙСТВИЯ СЕВОФЛЮРАНА НА АДРИАМИЦИН-ИНДУЦИРОВАННЫЕ ПОВРЕЖДЕНИЯ МИОЦИТОВ

https://doi.org/10.15829/1560-4071-2014-1-ENG-32-34

Аннотация

Целью исследования является изучение потенциального защитного эффекта севофлюрана на адриамицин- индуцированные повреждения миоцитов. Мы подготовили первичную культуру миоцитов новорожденных крыс и подвергли клетки воздействию адриамицина. Мы обнаружили, что воздействие адриамицина индуцирует апоптоз клеток, снижает жизнеспособность клеток, что может быть обратимо воздействием севофлюрана после медикаментозного лечения, возможно, через регулирование Bcl-2 антиапоптозных путей. В исследовании предлагается потенциальная роль севофлурана в области клинического ведения пациентов после химиотерапии адриамицином.

Об авторах

Li-hua Fan
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China


Xin Han
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China


Qing-quan Lian
Department of Anesthesiology, Wenzhou Medical College, the second Affiliated Hospital, Zhejiang, Wenzhou 325027, China


Jun Li
Department of Anesthesiology, Wenzhou Medical College, the second Affiliated Hospital, Zhejiang, Wenzhou 325027, China


Hou-xing Lei
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China


NIing Zhang
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China


Xiang-dong Xu
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China


Xiang-hong Lu
Department of Anesthesiology, Wenzhou Medical College, the Sixth Affiliated Hospital, Zhejiang, Lishui 323000, China


Список литературы

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Рецензия

Для цитирования:


Fan L., Han X., Lian Q., Li J., Lei H., Zhang N., Xu X., Lu X. ЭФФЕКТ ВОЗДЕЙСТВИЯ СЕВОФЛЮРАНА НА АДРИАМИЦИН-ИНДУЦИРОВАННЫЕ ПОВРЕЖДЕНИЯ МИОЦИТОВ. Российский кардиологический журнал. 2014;(1-ENG):32-34. https://doi.org/10.15829/1560-4071-2014-1-ENG-32-34

For citation:


Fan L., Han X., Lian Q., Li J., Lei H., Zhang N., Xu X., Lu X. EFFECT OF SEVOFLURANE EXPOSURE ON ADRIAMYCIN-INDUCED INJURIES TO MYOCYTES. Russian Journal of Cardiology. 2014;(1-ENG):32-34. https://doi.org/10.15829/1560-4071-2014-1-ENG-32-34

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ISSN 1560-4071 (Print)
ISSN 2618-7620 (Online)