vASCULAR AND CARDIAC REMODELLING AND COMbINATION THERAPY OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC ObSTRUCTIvE PULMONARY DISEASE
https://doi.org/10.15829/1560-4071-2014-1-95-100
Abstract
Aim. To assess cardiac and vascular structure and function, blood flow parameters, endothelial dysfunction, and cytokine status in patients with arterial hypertension (Ah) and chronic obstructive pulmonary disease (COPD), who were administered combination Co-renitec therapy.
Material and methods.The study included 37 patients with Ah and COPD, who underwent laboratory, functional, and ultrasound examination.
Results.During the 6-month combination Co-renitec therapy, the parameters of clinical status, circadian blood pressure profile, and endothelial, vascular, and cardiac structure and function were assessed in patients with Ah and COPD.
Conclusion. The combination Co-renitec therapy was associated with normalised
blood pressure levels, improved clinical and hemodynamic status, cardiac and vascular structure and function, and blood flow and microcirculation, as well as with reduced levels of the markers of endothelial dysfunction and systemic inflammation.
About the Authors
L. A. Shpagina
Novosibirsk state Medical University, Department of hospital Therapy and MedicalRehabilitation
Russian Federation
Russian Federation
I. S. Shpagin
Novosibirsk state Medical University, Department of hospital Therapy and MedicalRehabilitation
Russian Federation
Russian Federation
T. I. Pospelova
Новосибирский Государственный медицинский университет МЗ и СР РФ, кафедра госпитальной терапии и медицинской реабилитации
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
Novosibirsk state Medical University, Department of hospital Therapy and MedicalRehabilitation
O. N. Gerasimenko
Novosibirsk state Medical University, Department of hospital Therapy and MedicalRehabilitation; City Clinical hospital No. 2, Novosibirsk, Russia
Russian Federation
Russian Federation
N. A. Sukhaterina
Novosibirsk state Medical University, Department of hospital Therapy and MedicalRehabilitation; City Clinical hospital No. 2, Novosibirsk, Russia
Russian Federation
Russian Federation
Ya. M. Alicheva
Novosibirsk state Medical University, Department of hospital Therapy and MedicalRehabilitation; City Clinical hospital No. 2, Novosibirsk, Russia
Russian Federation
Russian Federation
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Review
For citations:
Shpagina L.A., Shpagin I.S., Pospelova T.I., Gerasimenko O.N., Sukhaterina N.A., Alicheva Ya.M. vASCULAR AND CARDIAC REMODELLING AND COMbINATION THERAPY OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC ObSTRUCTIvE PULMONARY DISEASE. Russian Journal of Cardiology. 2014;(1):95-100. (In Russ.) https://doi.org/10.15829/1560-4071-2014-1-95-100
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