Периваскулярная жировая ткань в патогенезе сердечно-сосудистых заболеваний

Периваскулярная жировая ткань (ПВЖТ) является активным регулятором сосудистого гомеостаза. В физиологических условиях она поддерживает нормальную функцию сосудов, выделяя антиатерогенные, противовоспалительные и вазодилатирующие биологически активные вещества. Дисфункциональная периваскулярная жировая ткань секретирует провоспалительные цитокины и адипокины, играющие важную роль в развитии сердечно-сосудистых заболеваний. В этом обзоре рассматривается функция периваскулярной жировой ткани в норме и патологии, ее вклад в патогенез атеросклероза, артериальной гипертензии, аневризмы аорты и васкулитных синдромов. Кроме того, представлены новые методы неинвазивного исследования ПВЖТ и потенциальные стратегии для таргетного лечения сердечно-сосудистых заболеваний.

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