Some pro- and anti-inflammatory cytokines, their genetic polymorphism and postinfarct cardiac remodeling
https://doi.org/10.15829/1560-4071-2020-4007
Abstract
The role of molecular genetic factors in cardiovascular disease (CVD) development has been actively studied in recent years. In patients with acute myocardial infarction and heart failure, the genetic component contributes to the determination of inflammation and persistence of inflammatory mediators in the myocardium. The genetic component in combination with traditional CVD risk factors determines the clinical course of the disease, the severity and its outcome. This review summarizes the data on relationship of proand anti-inflammatory cytokines with coronary artery disease and its clinical manifestations.
About the Authors
A. M. Nikolaeva
Cardiology Research Institute, Tomsk National Research Medical Center
Russian Federation
Tomsk
Russian Federation
Tomsk
N. P. Babushkina
Research Institute of Medical Genetics, Tomsk National Research Medical Center
Russian Federation
Tomsk
Russian Federation
Tomsk
V. V. Ryabov
Cardiology Research Institute, Tomsk National Research Medical Center;
National Research Tomsk State University;
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
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Review
For citations:
Nikolaeva A.M., Babushkina N.P., Ryabov V.V. Some pro- and anti-inflammatory cytokines, their genetic polymorphism and postinfarct cardiac remodeling. Russian Journal of Cardiology. 2020;25(10):4007. (In Russ.) https://doi.org/10.15829/1560-4071-2020-4007
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