Некоторые про- и противовоспалительные цитокины, полиморфные варианты их генов и постинфарктное ремоделирование сердца

Влияние молекулярно-генетических факторов на развитие сердечно-сосудистых заболеваний (ССЗ) уже на протяжении ряда лет является предметом активного изучения. У пациентов с острым инфарктом миокарда и сердечной недостаточностью в детерминации общего воспалительного фона и персистенции воспалительных медиаторов в миокарде очевидно наличие генетической компоненты. Генетический фон в комбинации с традиционными факторами риска ССЗ определяет характер клинического течения болезни, степень тяжести и ее исход. В настоящем обзоре обобщены данные ассоциативных исследований генов прои противовоспалительных цитокинов с ишемической болезнью сердца и ее клиническими проявлениями.

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