Association between biomarkers and progression of post-infarction myocardial remodelling
https://doi.org/10.15829/1560-4071-2013-1-65-69
Abstract
Aim. To study the association between the levels of inflammation and myocardial remodelling biomarkers and the progression of post-infarction left ventricular (LV) remodelling, based on the cardiac magnetic resonance tomography data.
Material and methods. The study included 60 patients with ST segment elevation myocardial infarction, who underwent the standard examination, measurement of serum biomarker levels, and cardiac magnetic resonance tomography, in order to assess the progression of myocardial remodelling.
Results. Progressing post-infarction myocardial remodelling was observed in 28,3% of the patients. There was an association between the levels of matrix metalloproteinase (MMP) 1 precursor, MMP-9, tissue inhibitor of MMP-1, N-terminal pro-brain natriuretic peptide (N-proBNP), interleukin-6 (IL-6), end-systolic and enddiastolic volume indices,LV ejection fraction, and damaged myocardial mass index.
Conclusion. The study emphasised the important role of the increased levels of MMP and their tissue inhibitor, N-proBNP, and IL-6 in the process of structural and functional post-infarctionLV remodelling.
About the Authors
G. A. Kukharchik
I. M. Mechnikov North-Western State Medical University, St. Petersburg, Russia
Russian Federation
Russian Federation
A. M. Pavlova
I. M. Mechnikov North-Western State Medical University, St. Petersburg, Russia
Russian Federation
Russian Federation
N. N. Nesterova
I. M. Mechnikov North-Western State Medical University, St. Petersburg, Russia
Russian Federation
Russian Federation
N. A. Mitrofanov
I. M. Mechnikov North-Western State Medical University, St. Petersburg, Russia
Russian Federation
Russian Federation
L. B. Gaikovaya
I. M. Mechnikov North-Western State Medical University, St. Petersburg, Russia
Russian Federation
Russian Federation
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Review
For citations:
Kukharchik G.A., Pavlova A.M., Nesterova N.N., Mitrofanov N.A., Gaikovaya L.B. Association between biomarkers and progression of post-infarction myocardial remodelling. Russian Journal of Cardiology. 2013;(1):65-69. (In Russ.) https://doi.org/10.15829/1560-4071-2013-1-65-69
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