GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME
https://doi.org/10.15829/1560-4071-2014-10-19-22
Abstract
Aim. To evaluate the relationship of 8 mononucleotide polymorphisms (MNP) with negative longterm prognosis of the acute coronary syndrome.
Material and methods. Totally 280 patients with acute coronary syndrome included (ACS), who during 1 year follow up were underwent the solid endpoints evaluation (cardiovascular death, hospitalization for recurrent ischemic event and repeated revascularization).
Results. In the analysis of rs4804611 in group with negative outcomes there is significantly more prevalent genotype GG (9,1% vs. 1,8%), chances relation 5,57 (95% CI 1,35-22,96); credibility of the differences kept in men (p=0,021). In the analysis rs2549513 in the group with positive prognosis the AA genotype was more prevalent (70,6% vs. 53%), hazard ratio 0,47 (95% CI 0,26-0,85), and in the group with negative prognosis genotype AC, chances relation 2,32 (95% CI 1,28-4,20; р=0,007).
While separated by gender credible differences were shown only in men (p=0,008).
Conclusion. Evaluation of genetic markers rs4804611 and rs2549513 can significantly increase prognostic value in riskometry of ACS outcomes.
About the Authors
N. G. Lozhkina
Novosibirsk State Medical University of the MH RF
Russian Federation
Russian Federation
V. N. Maksimov
Novosibirsk State Medical University of the MH RF; Scientific-Research Institute for Therapy and Prevention of the SD RAMS, Novosibirsk
Russian Federation
Russian Federation
P. S. Orlov
Scientific-Research Institute for Therapy and Prevention of the SD RAMS; Institute for Cytology and Genetics of SD RAMS, Novosibirsk
Russian Federation
Russian Federation
Kuimov A. D.
Novosibirsk State Medical University of the MH RF
Russian Federation
Russian Federation
M. I. Voevoda
Scientific-Research Institute for Therapy and Prevention of the SD RAMS; Institute for Cytology and Genetics of SD RAMS, Novosibirsk
Russian Federation
Russian Federation
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Review
For citations:
Lozhkina N.G., Maksimov V.N., Orlov P.S., D. K.A., Voevoda M.I. GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME. Russian Journal of Cardiology. 2014;(10):19-22. (In Russ.) https://doi.org/10.15829/1560-4071-2014-10-19-22
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