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Российский кардиологический журнал

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УЛЬТРАЗВУКОВЫЕ МАРКЕРЫ ДОКЛИНИЧЕСКОГО АТЕРОСКЛЕРОЗА СОННЫХ И БЕДРЕННЫХ АРТЕРИЙ В ОЦЕНКЕ СЕРДЕЧНО-СОСУДИСОГО РИСКА

https://doi.org/10.15829/1560-4071-2018-8-92-98

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Аннотация

Более половины сердечно-сосудистых событий происходит у лиц с низким или умеренным сердечно-сосудитым риском, который оценивается на основании традиционных факторов риска. При этом с помощью ультразвукового исследования артерий удается выявить атеросклероз уже на ранних стадиях его развития. Высокая частота наличия субклинического атеросклероза у лиц низкого и умеренного сердечно-сосудистого риска, который одновременно является реализацией как традиционных, так и еще «необъясненных» факторов риска, ультразвуковые маркеры атеросклероза имеет высокий потенциал улучшить стратификацию сердечно-сосудистого риска. В данном обзоре рассмотрены ультразвуковые маркеры атеросклероза с позиции их ассоциации с традиционными факторами риска, способности улучшать прогностическую ценность имеющихся шкал оценки риска, а также возможности влиять на исходы. Прогностическая значимость маркеров рассмотрена в рамках первичной профилактики среди представителей общей популяции, среди лиц высокого риска, а также с позиции количественного индикатора степени атеросклеротического поражения или способности выступать в качестве суррогатного маркера сердечно-сосудистых заболеваний.

Об авторах

А. И Ершова
ФГБУ "Национальный медицинский исследовательский центр профилактической медицины" Минздрава России
Россия
Ершова Александра Игоревна — кандидат медицинских наук, старший научный сотрудник


С. А. Бойцов
ФГБУ "Национальный медицинский исследовательский центр кардиологии" Минздрава России
Бойцов Сергей Анатольевич — доктор медицинских наук, профессор, член-корр. РАН, директор


О. М. Драпкина
ФГБУ "Национальный медицинский исследовательский центр профилактической медицины" Минздрава России
Драпкина Оксана Михайловна — член-корр. РАН, доктор медицинских наук, профессор, директор 


Т. В. Балахонова
ФГБУ Национальный медицинский исследовательский центр кардиологии Минздрава России
Балахонова Татьяна Валентиновна — главный научный сотрудник отдела ультразвуковых методов исследований


Список литературы

1. Hulten E, Villines TC, Cheezum MK, et al. Calcium score, coronary artery disease extent and severity, and clinical outcomes among low Framingham risk patients with low vs high lifetime risk: results from the CONFIRM registry. J Nucl Cardiol. 2014 Feb;21(1):29-37; quiz 38-9. doi: 10.1007/s12350-013-9819-7.

2. Piepoli MF, Hoes AW, Agewall S, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016 Sep;252:207-274. doi: 10.1016/j.atherosclerosis.2016.05.037.

3. Romanens M, Mortensen MB, Sudano I, et al. Extensive carotid atherosclerosis and the diagnostic accuracy of coronary risk calculators. Prev Med Rep. 2017 Mar 14;6:182-186. doi: 10.1016/j.pmedr.2017.03.006.

4. Polonsky TS, Greenland P. CVD screening in low-risk, asymptomatic adults: clinical trials needed. Nat Rev Cardiol. 2012 Oct;9(10):599-604. doi: 10.1038/nrcardio.2012.114.

5. Spence JD. Technology Insight: ultrasound measurement of carotid plaque--patient management, genetic research, and therapy evaluation. Nat Clin Pract Neurol. 2006 Nov;2(11):611-9. DOI: 10.1038/ncpneuro0324

6. Spence JD, Barnett PA, Bulman DE, et al. An approach to ascertain probands with a non-traditional risk factor for carotid atherosclerosis. Atherosclerosis. 1999 Jun;144(2):429-34.

7. Strong JP, Malcom GT, McMahan CA, et al. Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA. 1999 Feb 24;281(8):727-35.

8. Touboul PJ, Hennerici MG, Meairs S, et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis. 2012;34(4):290-6. doi: 10.1159/000343145.

9. Spence JD, Eliasziw M, DiCicco M, et al. Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy. Stroke. 2002 Dec;33(12):2916-22.

10. Held C, Hjemdahl P, Eriksson SV, et al. Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris. Eur Heart J. 2001 Jan;22(1):62-72. DOI: 10.1053/euhj.1999.2006.

11. Thorsson B, Eiriksdottir G, Sigurdsson S, et al. Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: the REFINE-Reykjavik study with comparison with the Tromsø study. BMJ Open. 2018 May 31;8(5):e019385. doi: 10.1136/bmjopen-2017-019385.

12. Willeit J, Kiechl S. Prevalence and risk factors of asymptomatic extracranial carotid artery atherosclerosis. A population-based study. Arterioscler Thromb. 1993 May;13(5):661-8.

13. Mannami T, Konishi M, Baba S, et al. Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factors in the general population of a Japanese city: the Suita study. Stroke. 1997 Mar;28(3):518-25.

14. Vikan T, Johnsen SH, Schirmer H, et al. Endogenous testosterone and the prospective association with carotid atherosclerosis in men: the Tromsø study. Eur J Epidemiol. 2009;24(6):289-95. doi: 10.1007/s10654-009-9322-2.

15. Zhernakova YV, Kaveshnikov VS, Serebriakova VN, et al. The prevalence of carotid atherosclerosis in spontaneous populations in Tomsk. Systemic Hypertension. 2014; 4: 37-42. (In Russ.)

16. Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, et al. Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation. 2015 Jun 16;131(24):2104-13. doi: 10.1161/CIRCULATIONAHA.114.014310.

17. Fernández-Friera L, Fuster V, López-Melgar B, et al. Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors. J Am Coll Cardiol. 2017 Dec 19;70(24):2979-2991. doi: 10.1016/j.jacc.2017.10.024.

18. Urazalina SJ, Semenova AE, Sergienko IV, et al. Subclinical atherosclerosis as cardiovascular events risk factor. Cardiovascular Therapy and Prevention. 2012; 11: 3: 82-86. (In Russ.)

19. Iglesias del Sol A, Bots ML, Grobbee DE, et al. Carotid intima-media thickness at different sites: relation to incident myocardial infarction; The Rotterdam Study. Eur Heart J. 2002 Jun;23(12):934-40. DOI: 10.1053/euhj.2001.2965.

20. Lorenz MW, von Kegler S, Steinmetz H, et al. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006 Jan;37(1):87-92. DOI: 10.1161/01.STR.0000196964.24024.ea

21. Lorenz MW, Markus HS, Bots ML, et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007 Jan 30;115(4):459-67. DOI: 10.1161/CIRCULATIONAHA.106.628875.

22. Polak JF, Pencina MJ, Pencina KM, et al. Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med. 2011 Jul 21;365(3):213-21. doi: 10.1056/NEJMoa1012592.

23. Nambi V, Chambless L, Folsom AR, et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol. 2010 Apr 13;55(15):1600-7. doi: 10.1016/j.jacc.2009.11.075.

24. Den Ruijter HM, Peters SA, Anderson TJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012 Aug 22;308(8):796-803. doi: 10.1001/jama.2012.9630.

25. Kastelein JJ, Akdim F, Stroes ES, et al. ENHANCE Investigators. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med. 2008 Apr 3;358(14):1431-43. doi: 10.1056/NEJMoa0800742.

26. Finn AV, Kolodgie FD, Virmani R. Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):177-81. doi: 10.1161/ATVBAHA.108.173609.

27. Spence JD, Hegele RA. Noninvasive phenotypes of atherosclerosis: similar windows but different views. Stroke. 2004 Mar;35(3):649-53. DOI: 10.1161/01.STR.0000116103.19029.DB.

28. de Barros IL, Costa L, Bezerra B, et al. Predictors of subclinical carotid atherosclerosis in middle-aged women. PLoS One. 2018 May 23;13(5):e0197582. doi: 10.1371/journal.pone.0197582.

29. Ershova AI, Balakhonova TV, Meshkov AN, et al. Ultrasound markers that describe plaques are more sensitive than mean intima-media thickness in patients with familial hypercholesterolemia. Ultrasound Med Biol. 2012 Mar;38(3):417-22. doi: 10.1016/j.ultrasmedbio.2011.11.014.

30. Inaba Y, Chen JA, Bergmann SR. Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis. Atherosclerosis. 2012 Jan;220(1):128-33. doi: 10.1016/j.atherosclerosis.2011.06.044.

31. Gepner AD, Young R, Delaney JA, et al. Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis. Circ Cardiovasc Imaging. 2015 Jan;8(1). pii: e002262. doi: 10.1161/CIRCIMAGING.114.002262.

32. Polak JF, Szklo M, Kronmal RA, et al. The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis. J Am Heart Assoc. 2013 Apr 8;2(2):e000087. doi: 10.1161/JAHA.113.000087.

33. Sakaguchi M, Kitagawa K, Nagai Y, et al. Equivalence of plaque score and intima-media thickness of carotid ultrasonography for predicting severe coronary artery lesion. Ultrasound Med Biol. 2003 Mar;29(3):367-71.

34. Morito N, Inoue Y, Urata M, et al. Increased carotid artery plaque score is an independent predictor of the presence and severity of coronary artery disease. J Cardiol. 2008 Feb;51(1):25-32. doi: 10.1016/j.jjcc.2007.09.003.

35. Ikeda N, Kogame N, Iijima R, et al. Carotid artery intima-media thickness and plaque score can predict the SYNTAX score. Eur Heart J. 2012 Jan;33(1):113-9. doi: 10.1093/eurheartj/ehr399.

36. Handa N, Matsumoto M, Maeda H, et al. Ischemic stroke events and carotid atherosclerosis. Results of the Osaka Follow-up Study for Ultrasonographic Assessment of Carotid Atherosclerosis (the OSACA Study). Stroke. 1995 Oct;26(10):1781-6.

37. Brook RD, Bard RL, Patel S, et al. A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery disease. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):656-62. DOI: 10.1161/01.ATV.0000200079.18690.60.

38. Johnsen SH, Mathiesen EB, Joakimsen O, et al. Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromsø Study. Stroke. 2007 Nov;38(11):2873-80. DOI: 10.1161/STROKEAHA.107.487264.

39. Yerly P, Rodondi N, Viswanathan B, et al. Association between conventional risk factors and different ultrasound-based markers of atherosclerosis at carotid and femoral levels in a middle-aged population. Int J Cardiovasc Imaging. 2013 Mar;29(3):589-99. doi: 10.1007/s10554-012-0124-3.

40. Laclaustra M, Casasnovas JA, Fernández-Ortiz A, et al. Femoral and Carotid Subclinical Atherosclerosis Association With Risk Factors and Coronary Calcium: The AWHS Study. J Am Coll Cardiol. 2016 Mar 22;67(11):1263-74. doi: 10.1016/j.jacc.2015.12.056.

41. Pasterkamp G, Schoneveld AH, Hillen B, et al. Is plaque formation in the common carotid artery representative for plaque formation and luminal stenosis in other atherosclerotic peripheral arteries? A post mortem study. Atherosclerosis. 1998 Mar;137(1):205-10.

42. Protogerou AD, Fransen J, Zampeli E, et al. The Additive Value of Femoral Ultrasound for Subclinical Atherosclerosis Assessment in a Single Center Cohort of 962 Adults, Including High Risk Patients with Rheumatoid Arthritis, Human Immunodeficiency Virus Infection and Type 2 Diabetes Mellitus. PLoS One. 2015 Jul 31;10(7):e0132307. doi: 10.1371/journal.pone.0132307.

43. Dalager S, Falk E, Kristensen IB, et al. Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: an autopsy study. J Vasc Surg. 2008 Feb;47(2):296-302. doi: 10.1016/j.jvs.2007.10.037.

44. Belcaro G, Nicolaides AN, Ramaswami G, et al. Carotid and femoral ultrasound morphology screening and cardiovascular events in low risk subjects: a 10-year follow-up study (the CAFES-CAVE study(1)). Atherosclerosis. 2001 Jun;156(2):379-87.

45. Ershova A.I., Meshkov A.N., Shalnova S.A., et al. Ultrasound parameters of carotid and femoral atherosclerosis in patients with coronary heart disease. Profilakticheskaya meditsina. 2014;17(6): 56-63. (In Russ.)

46. Hirano M, Nakamura T, Kitta Y, et al. Short-term progression of maximum intima-media thickness of carotid plaque is associated with future coronary events in patients with coronary artery disease. Atherosclerosis. 2011 Apr;215(2):507-12. doi: 10.1016/j.atherosclerosis.2011.01.014.

47. Baldassarre D, Veglia F, Hamsten A, et al. Progression of carotid intima-media thickness as predictor of vascular events: results from the IMPROVE study. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2273-9. doi: 10.1161/ATVBAHA.113.301844.

48. Lorenz MW, Gao L, Ziegelbauer K, et al. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLoS One. 2018 Apr 12;13(4):e0191172. doi: 10.1371/journal.pone.0191172.

49. Spence JD. Recent advances in pathogenesis, assessment, and treatment of atherosclerosis. F1000Res. 2016 Jul 28;5. DOI: 10.12688/f1000research.8459.1.

50. Nambi V, Bhatt DL. Primary Prevention of Atherosclerosis: Time to Take a Selfie? J Am Coll Cardiol. 2017 Dec 19;70(24):2992-2994. doi: 10.1016/j.jacc.2017.10.068.


Для цитирования:


Ершова А.И., Бойцов С.А., Драпкина О.М., Балахонова Т.В. УЛЬТРАЗВУКОВЫЕ МАРКЕРЫ ДОКЛИНИЧЕСКОГО АТЕРОСКЛЕРОЗА СОННЫХ И БЕДРЕННЫХ АРТЕРИЙ В ОЦЕНКЕ СЕРДЕЧНО-СОСУДИСОГО РИСКА. Российский кардиологический журнал. 2018;(8):92-98. https://doi.org/10.15829/1560-4071-2018-8-92-98

For citation:


Ershova A.I., Boytsov S.A., Drapkina О.M., Balakhonova Т.V. ULTRASOUND MARKERS OF PREMANIFEST ATHEROSCLEROSIS OF CAROTID AND FEMORAL ARTERIES IN ASSESSMENT OF CARDIOVASCULAR RISK. Russian Journal of Cardiology. 2018;(8):92-98. (In Russ.) https://doi.org/10.15829/1560-4071-2018-8-92-98

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