РОЛЬ ПУЛЬС-УРЕЖАЮЩЕЙ ТЕРАПИИ В ДОПОЛНИТЕЛЬНОМ УЛУЧШЕНИИ КЛИНИЧЕСКИХ ЭФФЕКТОВ РЕВАСКУЛЯРИЗАЦИИ МИОКАРДА У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА СО СТАБИЛЬНОЙ СТЕНОКАРДИЕЙ

Обзор посвящён роли ивабрадина в процедуре чрескожного коронарного вмешательства (ЧКВ) и коронарного шунтирования (КШ) у больных ишемической болезнью сердца (ИБС) со стабильной стенокардией. Приводятся данные о том, что реваскуляризация миокарда с помощью ЧКВ в сочетании с современной медикаментозной терапией не оказывает достаточного клинического эффекта. Авторы обосновывают возможность дополнения клинического эффекта ЧКВ или КШ у этих больных назначением им ивабрадина на фоне достаточных (до максимальных) доз бета-адреноблокаторов (БАБ). Ингибирование f-каналов кардиомиоцитов с помощью ивабрадина оказывает положительное влияние на основные клинические конечные точки. Сообщается о роли различных плеотропных эффектов ивабрадина, усиливающих эффективность препарата.

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