LASER DOPPLEROGRAPHIC FLOWMETRY IN ASSESSMENT OF FUNCTIONAL CONDITION OF THE SKIN MICROVESSELS IN PATIENTS WITH MICROVASCULAR ANGINA
https://doi.org/10.15829/1560-4071-2015-3-58-63
Abstract
Aim. To study functional condition of the skin microvessels by laser doppler flowmetry (LDF) with functional tests comparing to the parameters of myocardial flow reserve by the data of single-photon emission computed tomography (SPECT) in patients with microvascular angina (MVA).
Material and methods. Totally 44 patients with MVA included at the age of 58 [51;62] years and 30 healthy voluteers. LDF was performed on the skin of forearm with functional tests and perfusion SPECT with exercise or pharmacological test with sodium adenosinetriphosphate.
Results. By LDF of the skin data and warm test, in patients with MVA there is statistically significant decrease of dilatatory microcirculatory reserve comparing to healthy subjects. A relationship is revelaled of dilatatory potential by LDF of the skin with electrical stimulation, and the parameters of myocardial perfusion reserve by SPECT of myocardium with exercise test in MVA.
About the Authors
I. E. Karpova
FSBI Russian Cardiological Scientific-Production Complex of HM RF, Institute of Clinical Cardiology n. a. A. L. Myasnikov, Moscow
Russian Federation
Russian Federation
A. A. Fedorovich
FSBI Russian Cardiological Scientific-Production Complex of HM RF, Institute of Clinical Cardiology n. a. A. L. Myasnikov, Moscow
Russian Federation
Russian Federation
G. N. Soboleva
FSBI Russian Cardiological Scientific-Production Complex of HM RF, Institute of Clinical Cardiology n. a. A. L. Myasnikov, Moscow
Russian Federation
Russian Federation
L. E. Samoylenko
FSBI Russian Cardiological Scientific-Production Complex of HM RF, Institute of Clinical Cardiology n. a. A. L. Myasnikov, Moscow
Russian Federation
Russian Federation
A. N. Rogoza
FSBI Russian Cardiological Scientific-Production Complex of HM RF, Institute of Clinical Cardiology n. a. A. L. Myasnikov, Moscow
Russian Federation
Russian Federation
Yu. A. Karpov
FSBI Russian Cardiological Scientific-Production Complex of HM RF, Institute of Clinical Cardiology n. a. A. L. Myasnikov, Moscow
Russian Federation
Russian Federation
References
1. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007; 356: 830-40.
2. Working Group for management of stable coronary artery disease of the European Society of Cardiology (ESC). Guidelines for management of stable coronary artery disease Russ J Cardiol 2014; 7: 7-79. Russian (Рабочая группа по лечению стабильной ишемической болезни сердца Европейского общества кардиологов (ESC). Рекомендации по лечению стабильной ишемической болезни сердца ESC 2013. Российский кардиологический журнал 2014; 7: 7-79).
3. Lanza GA, Crea F. Primary coronary mycrovascular dysfunction: clinical presentation, pathophysiology, and management. Circulation 2010; 121: 2317-25.
4. Alekseeva OP, Dolbin IV, Fedorenko AA. Cardiac syndrome X (Pathogenesis and Treatment): monograf. — N. N ovgorod: Izdatel’stvo NGMA, 2007. 120 p. Russian (Алексеева О. П., Долбин И . В., Федоренко А. А. Кардиальный синдром Х (особенности патогенеза и лечения): монография. — Н. Новгород: Издательство НГМА, 2007. 120 с).
5. Sirotin BZ, Zhmereneckij KV. Microcirculation in cardiovascular diseases: monograph/ BZ. Sirotin, K. V. Zhmereneckij. Habarovsk: Izdatelstvo DVGMU, 2008. 150 p. Russian (Сиротин Б . З., Жмеренецкий К . В. Микроциркуляция при сердечно-сосудистых заболеваниях: монография / Б. З. С иротин, К. В. Жмеренецкий. — Хабаровск: Изд-во ДВГМУ, 2008. — 150 с).
6. Lockhart CJ, Hamilton PK, Quinn CE, et al. End-organ dysfunction and cardiovascular outcomes: the role of the microcirculation. Clin Sci. 2009; 116(3): 175-90.
7. Yamamoto-Suganuma R, Aso Y . Relationship between post-occlusive forearm skin reactive hyperaemia and vascular disease in patients with Type 2 diabetes — a novel index for detecting micro- and macrovascular dysfunction using laser Doppler flowmetry. Diabet Med. 2009; 26(1): 83-8.
8. IJzerman RG, de Jongh RT, Beijk MA, et al. Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin. Eur J Clin Invest. 2003; 33(7): 536-42.
9. Holowatz LA, Thompson-Torgerson CS, Kenney WL. The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol 2008; 105(1): 370-2.
10. Sax FL, Cannon RO 3rd, Hanson C, et al. Impaired forearm vasodilator reserve in patients with microvascular angina. Evidence of a generalized disorder of vascular function? N Engl J Med 1987; 317: 1366-70.
11. Karpova IE, Samojlenko LE, Soboleva GN, et al. Single photon emission computed tomography 99mTc-MIBI with pharmacological test with sodium adenosine triphosphate in the diagnosis of myocardial ischemia in patients with microvascular angina. Kardiologija 2014;7:4-8. Russian (Карпова И . Е., Самойленко Л. Е., Соболева Г . Н. и др. Применение однофотонной эмиссионной компьютерной томографии с 99mТс- МИБИ в сочетании с фармакологической пробой с аденозинтрифосфатом натрия в диагностике ишемии миокарда у больных с микроваскулярной стенокардией. Кардиология 2014;7:4-8).
12. Boytsov S . A., Fedorovich A. A., Rogoza A. N . The main parameters of microcirculatory blood flow in normal by laser Doppler flowmetry. Collection of scientific works of the N. I. Pirogov’s National Medical and Surgical Center 2009;2:86-101. Russian (Бойцов С . А., Федорович А. А., Рогоза А. Н. Основные параметры микроциркуляторного кровотока в норме по данным лазерной допплеровской флоуметрии. Сборник научных трудов Национального медико-хирургического центра им. Н. И . Пирогова 2009; том II: 86-101).
13. Krupatkin AI, Sidorov VV. Functional diagnostic of state of microcirculation-tissue systems: vibrations, information, nonlinearity (Manual for Physicians). M.: Knizhnyj dom “LIBROKOM”, 2013. 496 p. Russian (Крупаткин А. И ., Сидоров В. В. Ф ункциональная диагностика состояния микроциркуляторно-тканевых систем: колебания, информация, нелинейность (Руководство для врачей). М.: Книжный дом “ЛИБРОКОМ”, 2013. 496 с).
14. Khan F, Patterson D, Belch JJ, et al. Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography. Clin Sci 2008; 115(9): 295-300.
15. Szolcsanyi J. Neuroregulation of cutaneous microcirculation: the shadow of Sir Thomas Lewis.Trends in Pharmacological Science 2013; 34(11): 591-2.
16. Arildsson M, Asker CL, Salerud EG, et al. Skin capillary appearance and skin microvascular perfusion due to topical application of analgesia cream. Microvascular Research 2000; 59: 14-23.
17. Lim TK, Choy AJ, Khan F, et al. Therapeutic development in cardiac syndrome X: a need to target the underlying pathophysiology. Cardiovasc Ther 2009; 27(1): 49-58.
Review
For citations:
Karpova I.E., Fedorovich A.A., Soboleva G.N., Samoylenko L.E., Rogoza A.N., Karpov Yu.A. LASER DOPPLEROGRAPHIC FLOWMETRY IN ASSESSMENT OF FUNCTIONAL CONDITION OF THE SKIN MICROVESSELS IN PATIENTS WITH MICROVASCULAR ANGINA. Russian Journal of Cardiology. 2015;(3):58-63. (In Russ.) https://doi.org/10.15829/1560-4071-2015-3-58-63
Views:
885
Email this article 