Long-term prognosis of CHD depends on fat tissue levels of lipophylic antioxidants and polyunsaturated fatty acids in patients with acute myocardial infarction
Abstract
To assess influence of the natural fat tissue levels of lipophylic antioxidants and polyunsaturated fatty acids (PUFA) in patients with acute myocardial infarction (MI), on coronary heart disease (CRD) progression. Sixty patients, who had MI in 1991-92, were surveyed and included into the main group of EURAMIC study. According to the variants of CHD progression (death, recurrent MI, stroke, myocardial revascularization), all participants were divided into two groups: 25 individuals without CHD progression (Pr-), and another 35 - with CHD progression (Pr+). To study complex influence of traditional CVD risk factors, lipophylic antioxidants and PUFA levels on the long-term prognosis, as well as for assessing the individual input of each variable, multiple regression analysis was used. The results obtained have demonstrated the following: 1. Carotinoid and PUFA levels in fat tissue of acute MI patients did influence the long-term prognosis of CHD. 2. In patients with MI, decreased level of low-density lipoprotein cholesterol was a significant predictor of poor prognosis. 3. In initially normostenic MI patients, further increase in body mass index associated with worse CHD prognosis.
About the Authors
I. G. Shiman
ГУ «Государственный научно-исследовательский центр профилактической медицины МЗ и СР России
Russian Federation
Russian Federation
V. P. Mazaev
ГУ «Государственный научно-исследовательский центр профилактической медицины МЗ и СР России
Russian Federation
Russian Federation
Yu. M. Popov
ГУ «Государственный научно-исследовательский центр профилактической медицины МЗ и СР России
Russian Federation
Russian Federation
S. V. Ryazanova
ГУ «Государственный научно-исследовательский центр профилактической медицины МЗ и СР России
Russian Federation
Russian Federation
G. V. Kuznetsova
ГУ «Государственный научно-исследовательский центр профилактической медицины МЗ и СР России
Russian Federation
Russian Federation
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Review
For citations:
Shiman I.G., Mazaev V.P., Popov Yu.M., Ryazanova S.V., Kuznetsova G.V. Long-term prognosis of CHD depends on fat tissue levels of lipophylic antioxidants and polyunsaturated fatty acids in patients with acute myocardial infarction. Russian Journal of Cardiology. 2004;(4):58-64. (In Russ.)
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