EVALUATION OF CARVEDILOL EFFECTS ON THE BASIC DATA OF LEFT VENTRICLE SYSTOLIC AND DIASTOLIC FUNCTION AFTER ACUTE MYOCARDIAL INFARCTION

We have examinated 106 patients with primary acute myocardial Q-infarction. Favourable effects of carvedilol on basic parameters of central, intracardial and peripheral hemodynamic was identificated. Carvedilol did not increase general peripheral vascular resistance during long-term carvedilol administration. It is determined that carvedilol contributes to decrease in left ventricular volume values in patients with acute myocardial infarction by reducing pre- and postloading. The drug improves myocardial contractility, and so does transmitral blood flow parameters. Carvedilol promotes to stabilization left ventricular systolic and diastolic function of patients with primary acute myocardial infarction. The treatment with carvedilol reduces end-systolic size (7,1%) and volume (14,3%), general peripheral (28,5%) and specific peripheral (14%) vascular resistance. Carvedilol increases ejection fraction (14%), fraction shortening (10,1%). 

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