ПОВЫШЕННАЯ ЧУВСТВИТЕЛЬНОСТЬ ЛИПОПРОТЕИНОВ НИЗКОЙ ПЛОТНОСТИ К ОКИСЛЕНИЮ КАК ФАКТОР РИСКА АТЕРОСКЛЕРОЗА
Аннотация
Повышенная чувствительность липопротеинов низкой плотности к окислению какфактор риска атеросклероза.
Об авторах
Ю. П. Никитин
Научно-исследовательский институт терапии СО РАМН, Новосибирск
Россия
Россия
Ю. И. Рагино
Научно-исследовательский институт терапии СО РАМН, Новосибирск
Россия
Россия
Список литературы
1. Душкин М.И., Зыков А.А., Пивоварова Е.Н. Влияние природных полифенольных соединений на окислительную модификацию липопротеинов низкой плотности // Бюлл. экспер. биол. мед. - 1993. -№ 10. - С. 393-395.
2. Душкин М.И., Зенков Н.К., Менщикова Е.Б. и др. Влияние ингибиторов цитохромаР-450 на окислительную модификацию липопротеинов низкой плотности // Вопр. мед. химии. - 1996. -№ 1. -С. 23-29.
3. Зенков Н.К., Душкин М.И., Меньщикова Е.Б., Рагино Ю.И. Ин- гибирование мелатонином окисления липопротеинов низкой плотности. //Бюлл. экспер. биол. имед. -1996. -№. 10. -С.399-402.
4. Климов А.Н., Никульчева Н.Г. Липиды, липопротеиды и атеросклероз // Санкт-Питербург: Питер Пресс. -1995. -298 с.
5. Ланкин В.З., Вихерт А.М., Тихазе А.К., Согоян С.М., Бондарь Т.Н. Роль перекисного окисления липидов в этиологии и патогенезе атеросклероза // Вопр. мед. химии -1989. -№ 3. С. 18-24.
6. Меньщикова Е.Б., Зенков Н.К., Шергин С.М. Биохимия окислительного стресса: оксиданты и антиоксиданты //Новосибирск. -1994. -203 с.
7. Никитин Ю.П., Душкин М.И., Рагино Ю.И. Резистентность к окислению субфракций липопротеинов низкой плотности у больных ишемической болезнью сердца. // Кардиология. -1998. - № 10. -С. 48-52.
8. Орехов А.Н., Тертов В.В., Назарова В.Л. Множественные модификации липопротеидов низкой плотности в крови больных атеросклерозом //Бюлл. экспер. биол. имед. -1995. -№.8. -C.118-121.
9. Рагино Ю.И., Душкин М.И., Никитин Ю.П. Снижение резистентности к окислению липопротеинов очень низкой плотности и отдельных субфракций липопротеинов низкой плотности у больных инсулиннезависимым сахарным диабетом // Тер.- архив. -1999. -№. 4. -С. 52-55.
10. Рагино, А.В. Рабко, М.И. Душкин. Резистентность к окислению гепарин-осажденных в-липопротеинов сыворотки крови у больных инфарктом миокарда. // Клин. лаб. диагностика. - 1999. -№ 7. -С. 3-5.
11. Рагино Ю.И., Латынцева Л.Д., Иванова М.В., Никитин Ю.П. Резистентность к окислению липопротеинов низкой плотности у больны хартериальной гипертонией при приеме валсартана и эналаприла. // Клиническая фармакология и терапия. -1999. -№ 4. -С. 32-34.
12. Тихазе А.К., Ланкин В.З., Михин В.П., Ревенко В.М., Лупанов В.П. Антиоксидант пробукол как регулятор интенсивности процессов свободнорадикального перекисного окисления липидов в крови больных коронарным атеросклерозом // Тер. архив. -1997. -№ 9. -С. 38-41.
13. Austin M.A., King M., Vranizan K.M. and Krauss R.M. Atherogenic lipoprotein phenotype A proposed genetic marker for coronary heart disease risk //Circulation. -1990. -V.82. -P.495-506.
14. Aviram M., Dankner G., Cogan U. et al. Lovastatin inhibits lowdensity lipoprotein oxidation and alters its fluidity and uptake by macrophages: in vitro and in vivo studies // Metabolism. -1992. -V. 41. -P. 229-235.
15. Aviram M., Kasem E. Dietary olive oil reduces the susceptibility of low-density lipoprotein to lipid peroxidation and inhibits lipoprotein uptake by macrophages // Ann. Nutr. Metabol. -1993. -V. 37. -P. 75-84.
16. Aviram M. Oxidative modification of low density lipoprotein and its relation to atherosclerosis // Isr. J. Med. Sci. -1995. -V.31. -P.241-249.
17. Aviram M. Macrophages, LDL oxidation and atherosclerosis // Atherosclerosis - XI. - 1998. -P. 483-492.
18. Ayaori M., Ishikawa T., Yoshida H. et al. Beneficial effects of alcohol withdrawal on LDL particle size distribution and oxidative susceptibility in subjects with alcohol-induced hypertriglyceridemia // Arterioscler. Thromb. Vasc. Biol. -1997. -V. 17. -P. 2540-2547.
19. Berliner J.A., Territo M.C., Sevanian A. et al. Minimally modified low density lipoprotein stimulates monocyte-endothelial interactions. // J. Clin. Invest. -1990. -V.85. -P.1260-1266.
20. Berliner J.A., Territo M., Navab M. et al. Minimally modified lipoproteins in diabetes // Diabetes. -1992. -V. 41. -P. 74-76.
21. Betteridge D.J. Lipids and atherogenesis in diabetes mellitus // Atherosclerosis. -1996. -V.124. -P. 543-547.
22. Campos H., Blijlevens E., Mc Namara J.R. et al. LDL particle size distribution //Arterioscler. Thromb. -1992. -V.12. -P.1410-1419.
23. Chait A., Brazg R.L., Krauss R.M. Increased oxidative susceptibility of LDL subfractions in subjects with the atherogenic lipoprotein phenotype //Arterioscler. Thromb. -1991. -V.11. -P.1425a.
24. Chapman M.J., Laplaud P.M., Luc G. et al. Further resolution of the low density lipoprotein spectrum in normal human plasma: physicochemical characteristics of discrete subspecies separated by density gradient ultracentrifugation //J. Lipid Res. -1988. -V.29. -P.442-458.
25. Chapman M.J., Lund-Katz S., Phillips M.C. et al. LDL subfractions: properties and functions //Atherosclerosis. -1995. -P.977-979.
26. Chapman M.J., Bruckert E. The atherogenic role of triglycerides and small, dense low density lipoproteins: impact of ciprofibrate therapy //Atherosclerosis. -1996. -V.124. -P.921-928.
27. Chappey B., Myara I., Benoit M.O. et al. Characteristics of ten charge-differing subfractions isolated from human native low-density lipoproteins (LDL). No evidence of peroxidative modifications // Biochеm. et Biophysica Acta. -1995. -V.1259. -P.261-270.
28. Cominacini L., Garbin U., Cenci B. et al. Predisposition to LDL oxidation during copper-catalyzed oxidative modification and its relation to α-tocopherol content in humans // Clin. Chem. Acta. - 1991. -V. 204. -P. 57-68.
29. Cominacini L., Pastorino A.M., Garbin U. et al. The susceptibility of low-density lipoprotein to in vitro oxidation is increased in hypercholesterolemic patients //Nutrition. -1994. -V.10. -P.527-531.
30. Day A.P., Kemp H.J., Bolton C. et al. Effect of concentrated red grape juice consumption on serum antioxidant capacity and lowdensity lipoprotein oxidation // Ann. Nutr. Metabol. -1997. -V. 41. - P. 353-357.
31. De Graaf J., Hak-Lemmers H.L.M., Hectors M.P.S. et al. Enhanced susceptibility to In Vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects // Arterioscler. Thromb. -1991. -V. 11. -P.2988-306.
32. De Graaf J., Demacker P.N.M., Stalenhoef A.F.H. LDL oxidation and coronary atherosclerosis //Lancet. -1992. -V.340. -P.123-124.
33. Dejager S., Bruckert E., Chapman M.J. Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia //J. Lipid Res. -1993. - V.34. -P.295-308.
34. De Rijke Y.B., Vogelezang C.J.M., Van Berkel T.J.C. et al. Susceptibility of low-density lipoproteins to oxidation in coronary bypass patient //Lancet. -1992. -V.340. -P.858-859.
35. Destypere J.P. Modified lipoproteins in diabetes //J. Intern. Med. - 1994. -V.236. -P.69-74.
36. Diekmann T., Demacker P.N.M., Kastelein J.J.P. et al. Increased oxidizability of low-density lipoproteins in hypothyroidism // J. of Clin. Endocrin. Metabol. -1998. -V. 83. -P. 1752-1755.
37. Dugas T.R., Morel D.W., Harrison E.H. Impact of LDL carotenoid and a-tocopherol content on LDL oxidation by endothelial cells in culture // J. Lipid Res. -1998. -V. 39. -P. 999-1007.
38. Dushkin M.I., Schwartz Ya.Sh. Effect of verapamil and nifedipine on cholesteryl ester metabolism and low density lipoprotein oxidation in macrophages // Biochem. Pharmacol. -1995. -V.49. N 3. -Р. 389-397.
39. Dushkin M.I., Zenkov N.K., Menshikova E.B., Pivovarova E.N., Lyubimov G.Yu., Volsky N.N. Ketokonazole inhibits oxidative modification of LDL .// Atherosclerosis. -1995. -V. 114. -Р. 9-18.
40. Esterbauer H., Jurgens G., Quehenberger O., Koller E. Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes //J. Lipid Res. -1987. - V.28. -P. 495-509.
41. Esterbauer H., Striege G., Puhl H., Rotheneder M. Continuous monitоring of in vitro oxidation of human LDL // Free Rad. Res. Commun. -1989. -V.6. -P.67-72.
42. Esterbauer H., Dieber-Rotheneder M., Waeg G. et al. Biochemical, structural and functional properties of oxidised low-density lipoprotein //Chem. Res. Toxicol. -1990. -V.3. -P.77-92.
43. Esterbauer H., Puhl H., Dieber-Rotheneder M. et al. Effect of antioxidants on oxidative modification of LDL //Ann. Med. -1991. -V.23. -P.573-581.
44. Esterbauer H., Dieber-Rotheneder M., Striegl G., Waeg G. Role of vitamin E in prevention of LDL oxidation. // Am. J. Clin. Nutr. - 1991. -V.53. -P.3145-3215.
45. Esterbauer H., Gebicki J., Puhl H., Jurgens G. The role lipid peroxidation and antioxidants in oxidative modification of LDL. // Free Rad. Biol. Med. -1992. -V.13. -P.341-390.
46. Esterbauer H. and Jurgens G. Mechanistic and genetic aspects of susceptibility of LDL to oxidation //Curr. Opin. Lipidol. -1993. - V.4. -P.114-124.
47. Esterbauer H., Wag G., Puhl H. Lipid peroxidation and its role in atherosclerosis //Br. Med. Bul. -1993. -V.49. -P.566-576.
48. Fuhrman B., Oiknine J., Aviram M. Iron induces lipid peroxidation incultured macrophages and affects their secretory properties. // Atherosclerosis. -1994. -V.11. -P.65-78.
49. Fuhrman B., Lavy A., Aviram M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation // Am. J. Clin. Nutr. -1995. -V. 61. -P. 549-554.
50. Fuhrman B., Ben-Yaish L., Attias J., Hayek T., Aviram M. Tomato’s lycopene and β-carotene inhibit low-density lipoprotein oxidation and this effect depends on the lipoprotein vitamin E content // Nutr. Metab. Cardiovasc. Dis. -1997. - V. 7. -P. 433-443.
51. Gey K.F., Puska P. Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology //Ann. NY Acad.Sci.-1989. -V. 570.-P.268-282.
52. Gey K.F., Puska P., Jordan P., Moser U.K. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology // Am. J. Clin. Nutr. -1991. -V.53. - P.326S-334S.
53. Goldstein J.L., Ho Y.K., Brown M.S., Jnnerarity T.L., Mahley R.W. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine - very low-density lipoproteins // J. Biol. Chem. -1980. - V.255. -N.5. -P.1839-1848.
54. Haberland M.E., Olch C.L., Fogelman A.M. Role of lysines in mediating interaction of modified low-density lipoproteins with the scavenger receptor of human monocyte macrophages // J. Biol. Chem. -1988. -V.259. -N.18. -P.11305-11311.
55. Hayek T., Oiknine J., Dankner G. et al. HDL apolipoprotein A-I attenuates oxidative modification of low-density lipoprotein: studies in transgenic mice. // Eur. J. Clin. Chem. Clin. Biochem. -1995. -V. 33. -P. 721-725.
56. Hayek T., Fuhrman B., Via J. et al. Reduced progression of atherosclerosis in the apolipoprotein E deficient mice following consumption of red wine, or its polyphenols quercetin, or catechin, is associated with reduced susceptibility of LDL to oxidation and to aggregation / / Arterioscler. Thromb. Vasc. Biol. -1997. -V. 17. -P. 2744-2750.
57. Heinecke J.W., Baker L., Rosen H., Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. // J. Clin. Invest. -1986. -V.77. -P.757-763.
58. Jones A.A., Disilvestro R.A., Coleman M., Wagner T.L. Copper supplementation of adult men: effects on blood copper enzyme activities and indicators of cardiovascular disease risk // Metabolism - Clinical and Experimental. -1997. -V. 46. -P. 1380-1383.
59. Keidar S., Shapira C., Kaplan M., Brook J.G., Aviram M. Lowdensity lipoprotein isolated from hypertensive patients exhibits increased propensity for oxidation and enhanced uptake by macrophages. //Harefua. -1992. -V.122. -P. 415-418.
60. Keidar S., Kaplan M., Hoffman A., Brook J.G., Aviram M. Angiotensin II stimulates macrophage-mediated lipid peroxidation of low-density lipoprotein. //Atherosclerosis. -1995. -V. 115. -P. 201-215.
61. Kostner K., Hornykewycz S., Yang P. et al. Is oxidative stress causally linked to unstable angina pectoris? A study in 100 CAD patients and matched controls // Cardiovasc. Res. -1997. -V. 36. - P. 330-336.
62. Krauss R.M. Low-density lipoprotein subclasses and risk of coronary artery disease //Curr. Opin. Lipidol. -1991. -V.2. -P.248-252.
63. Krauss R.M. Heterogeneity of plasma low-density lipoproteins and atherosclerosis risk //Curr. Opin. Lipidol. -1994. -V.5. -P.339-348.
64. Lamb D.J., Willins G.M., Leake D.S. The oxidative modification of LDL by human lymphocytes. // Atherosclerosis. -1992. -V.92. -P.87-91.
65. Leake D.S., Rankin S.H. The oxidative modidication of LDL by macrophages //Biochem. J. -1990. -V.270. -P.741-748.
66. Leake D.S. Effects of mildly oxidised low-density lipoprotein on endothelial cell function //Curr. Opin. Lipidol. -1991. -V.2. -P.301-305.
67. Levy Y., Ben-Amotz A., Aviram M. Effect of dietary supplementation of β-carotene to humans on its binding to plasma LDL and on the lipoprotein susceptibility to undergo oxidative modification: comparison of the synthetic all transisomer with the natural algae β-carotene // J. Nutr. Envir. Med. -1995. -V. 5. -P. 13-22.
68. Lyons T.J. Clycation and oxidation: a role in the pathogenesis of atherosclerosis. // Am. J. Cardiol. -1993. -V.71. -P.26В-31В.
69. Mackness M.I., Mackness B., Durrington P.N. et al. Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins // Curr. Opin. Lipid. -1996. -V. 7. -P. 69-76.
70. Nigon F., Lesnik P., Rouis M., Chapman M.J. Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor //J. Lipid Res. -1991. - V.32. -P.1741-1753.
71. Nouroozzadeh J., Tajaddinisarmadi J., Ling K.L.E., Wolff S.P. Low density lipoprotein is the major carrier of lipid hydroperoxides in plasma - Relevance to determination of total plasma lipid hydroperoxide concentrations.//Biochem. J. -1996. -V. 313. -P. 781-786.
72. Obrien R.C., Luo M. The effects of gliclazide and other sulfonylureas on low-density lipoprotein oxidation in vitro // Metabolism - Clin. and Experim. -1997. -V. 46. -P. 22-25.
73. Otero P., Viana M., Herreta E., Bonet B. Antioxidant and prooxidant effects of ascorbic acid, dehydroascorbic acid and flavonoids on LDL submitted to different degrees of oxidation // Free rad. res. - 1997. -V. 27. -P. 619-626.
74. Palinski W., Rosenfeld M.E., Yla-Herttuala A. et al. Low density lipoprotein undergoes oxidative modification in vivo. // Proc. Natl. Sci. USA. -1989. -V.86. -P.1372-1376.
75. Parthasarathy S., Khoo J.C., Miller E., Bamett J., Witztum J.L., Steinberg D. Low density lipoprotein enriched in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis. // Proc. Natl. Acad. Sci. USA. - 1990. -V.87. -P.3894-3898.
76. Pinchuk I., Schnitzer E., Lichtenberg D. Kinetic analysis of copperinduced peroxidation of LDL // Biochem. Biophys. Acta - Lipids Lip. Metab. -1998. -V. 1389. -P. 155-172.
77. Qin X.F., Swertfeder D.K., Zheng S.Q. et al. Apolipoprotein AIV: a potent endogenous inhibitor of lipid oxidation // Am. J. Physiology - Heart and circul. physiology. -1998. -V. 43. -P. H1836-H1840.
78. Reaven P.D., Parthasarathy S., Beltz W.F., Witztum J.L. Effect of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans // Arterioscler. Thromb. -1992. -V. 12. -P. 318-324.
79. Regnstrom J., Nilsson J., Tornvall P. et al. Susceptibility low-density lipoprotein to oxidation and coronary atherosclerosis in man //Lancet. -1992. -V.339. -P.1183-1186.
80. Shaikh M., Martini S., Quiney J.R. et all. Modified plasma-derived lipoproteins in human atherosclerotic plaques. // Atherosclerosis. - 1988. -V.69. -P165-172.
81. Siekmeier R., Wulfroth P., Wieland H. et al. Low density lipoprotein susceptibility to in vitro oxidation in healthy smokers and nonsmokere //Clinic. Chem. -1996. -V.42. -P.524-530. 82. Stampfer M.J., Rimm E.B. Epidemiologic evidence for vitamin E in the prevention of cardiovascular disease // Am. J. Clin. Nutr. - 1995. -V. 62 (suppl.). -P. 1365S-1369S.
82. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol: modification of low density lipoprotein that increase its atherogenicity. // N. Engl. J. Med. -1989. -V.320. -P.915-924.
83. Steinberg D. and workshop participants. Antioxidants in the prevention of human atherosclerosis. // Circulation. -1992. -V. 85. -P. 2338-2344.
84. Steinberg D. LDL oxidation and atherogenesis // Atherosclerosis IX, R and L Creative Commun. Ltd., Tel Aviv, Israel -1992. -P.41-46.
85. Steinbrecher U.P., Parthasarathy S., Leake D.S, Witztum J.L.,Steinberg D. Modification of low density lipoprotein by endothelial cells invoves lipid peroxidation and degradation of low density lipoprotein phospholipids. // Proc. Natl. Acad. Sci. USA. - 1984. -V.81. -P.3883-3887.
86. Steinbrecher U.P. Oxidatively modified lipoproteins //Curr. Opin. Lipidol. -1990. -V.1. -P.411-415.
87. Stephens N.J., Parsons A., Schofield P.M. et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study // Lancet. -1996. -V. 347. -P. 781-786.
88. Tribble D.L., Holl L.G., Wood P.D., Krauss R.M. Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size //Atherosclerosis. -1992. -V.93. -P.189-199.
89. Tribble D.L., Krauss R.M., Lansberg M.G. et al. Greater oxidative susceptibility of the surfase monolayer in small dense LDL may contribute to differences in copper-induced oxidation among LDL density subfractions //J. of Lipid Research. -1995. -V.36. -P.662-671.
90. Vanderveen C., Carpenter K.L.H., Taylor S.E. et al. Factors affecting events during oxidation of LDL: correlation of multiple parameters of oxidation // Free Rad. Res. -1997. -V. 27. -P. 459-476.
91. Vanjaarsveld H., Pool G.F., Barnard H.C. Influence of ferritin levels on LDL cholesterol concentration in women // Res. Commun. mol. pathol. pharmacol. -1997. -V. 98. -P. 201-208.
92. Vijayalingam S., Parthiban A., Shanmugasundaram K.R., Mohan V. Abnormal antioxidant status in impaired glucose tolerance and NIDDM //Diabetic Med. -1996. -V. 13. -P.715-720.
93. Yla-Herttuala S., Palinski W., Rosenfeld M.E., Parthasarathy S., Carrew T.E., Butler S. et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man // J. Clin. Invest. -1989. -V.84. -P.1086-1095.
94. Yla-Herttuala S. Biochemistry of the arterial wall in developing atherosclerosis. // Ann. NY Acad. Sci. -1991. -V.623. -P.40-59.
95. Yla-Herttuala S. Macrophages and oxidized low density lipoproteins in the pathogenesis of atherosclerosis // Ann. Med. -1991. -V.23. - P.561-567.
96. Yokozawa T., Dong E.B. Influence of green tea and its three major components upon low-density lipoprotein oxidation // Experim. toxicol. pathol. -1997. -V. 49. -P. 329-335.
97. Zieden B., Molgaard J., Olsson A.G. Low-density lipoprotein oxidation and coronary atherosclerosis //Lancet. -1992. -V.340. -P.727-728.
Рецензия
Для цитирования:
Никитин Ю.П., Рагино Ю.И. ПОВЫШЕННАЯ ЧУВСТВИТЕЛЬНОСТЬ ЛИПОПРОТЕИНОВ НИЗКОЙ ПЛОТНОСТИ К ОКИСЛЕНИЮ КАК ФАКТОР РИСКА АТЕРОСКЛЕРОЗА. Российский кардиологический журнал. 2002;(1):61-70.
For citation:
Nikitin Y.P., Ragino Y.I. INCREASED LDLP SENSITIVITY TO OXIDATION AS A RISK FACTOR FOR ATHEROSCLEROSIS. Russian Journal of Cardiology. 2002;(1):61-70. (In Russ.)
Просмотров:
539
Послать статью по эл. почте 