THRESHOLD PROGNOSTIC INDICES OF QT AND RR VARIABILITY AND DURATION IN AN UNORGANIZED MALE POPULATION
Abstract
QT duration and variability, as well as RR dispersion are considered noninvasive tools for identifying persons prone to life-threatening ventricular arrhythmias and sudden death. Under the auspices of the WHO ”Monica” project in Novosibirsk a representative sample of unorganized male population aged 25 to 64 was evaluated by standard epidemiological methods. Fatal endpoints were established by retrieving sample cases from the overall morality register. Resting ECG was analyzed in a blinded mode (in respect to the other studied data) with the Minnesota criteria. QT and QTc duration and dispersion were measured manually in addition, as well as the temporal parameters of RR variability. Threshold prognostic indices were calculated through a combination of ROC analysis (search for “separation points” on the characteristic curve) and “survival” estimation methods (Cox model, Gehan’s Wilcoxon test, Kaplan-Meier curves) The indices developed (QTc and QTc max >=420-440 mses, DQT and DQTc>=60 msec, SDNN<=20 msec) outline persons with 2 to 3-fold increased risk of all causes death and 4 to 5-fold increased risk of cardiovascular death.
About the Authors
Y. P. Nikitin
НИИ терапии Сибирского отделения РАМН, Новосибирск
Russian Federation
Russian Federation
A. A. Kuznetsov
НИИ терапии Сибирского отделения РАМН, Новосибирск
Russian Federation
Russian Federation
S. K. Malyutina
НИИ терапии Сибирского отделения РАМН, Новосибирск
Russian Federation
Russian Federation
G. I. Simonova
НИИ терапии Сибирского отделения РАМН, Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Nikitin Y.P., Kuznetsov A.A., Malyutina S.K., Simonova G.I. THRESHOLD PROGNOSTIC INDICES OF QT AND RR VARIABILITY AND DURATION IN AN UNORGANIZED MALE POPULATION. Russian Journal of Cardiology. 2002;(5):47-53. (In Russ.)
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