Koronary heart disease clinical course, post-infarction remodeling, psychological status, and hospitalization time in patients with various ACE genotypes
Abstract
Clinical, instrumental and psychosomatic associations of ACE gene insertion/deletion (I/D) polymorphism were studied in inpatients with coronary heart disease (CHD): unstable angina (UA) - 32, myocardial infarction (MI) - 80. The control group included 66 healthy volunteers (CG). ACE gene D allele was more prevalent than I allele (p < 0.02) in CHD and MI patients. These groups also had significant difference in DD genotype prevalence, comparing to CG (p < 0.05). According to echocardiography results, severe left ventricular hypertrophy (IVH) was associated with DD genotype. According to psychometry data, patients with DD genotype had increased levels of total hostility and Type A behavior manifestation than patients with ID or II genotype (p < 0.05). Prolonged hospitalization time in MI patients with DD genotype was significantly associated with severity of Type A behavior and various hostility components (p < 0.05).
About the Authors
I. A. Melentyev
Российский государственный медицинский университет
Russian Federation
Russian Federation
A. A. Vershinin
Российский государственный медицинский университет
Russian Federation
Russian Federation
E. A. Kolesnikova
Российский государственный медицинский университет
Russian Federation
Russian Federation
A. S. Melentyev
Российский государственный медицинский университет
Russian Federation
Russian Federation
N. A. Malygina
Российский научноFисследовательский институт геронтологии
Russian Federation
Russian Federation
I. V. Kostomarova
Российский научноFисследовательский институт геронтологии
Russian Federation
Russian Federation
V. P. Zaitsev
Российский научный центр восстановительной медицины и курортологии
Russian Federation
Russian Federation
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Review
For citations:
Melentyev I.A., Vershinin A.A., Kolesnikova E.A., Melentyev A.S., Malygina N.A., Kostomarova I.V., Zaitsev V.P. Koronary heart disease clinical course, post-infarction remodeling, psychological status, and hospitalization time in patients with various ACE genotypes. Russian Journal of Cardiology. 2006;(3):6-16. (In Russ.)
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