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ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ: ГЕНЕТИКА, КЛИНИКА, ЭКСПЕРИМЕНТ

https://doi.org/10.15829/1560-4071-2017-10-133-139

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Аннотация

Материал лекции посвящен рассмотрению генетико-физиологических механизмов гипертонической болезни (ГБ). Дается очень краткая историческая справка о первоначальном формировании клинических представлений о ГБ. Приводятся рассуждения об этиологии ГБ, рассмотрены ее эволюционно-генетические корни в связи с формированием основных систем регуляции АД. Более подробно излагаются сведения о генетической основе гипертензивных состояний и ГБ. Отдельно говорится о моногенных формах артериальной гипертензии и о полигенной основе ГБ, которой представлено подавляющее число случаев гипертензивных состояний человека. Рассмотрены современные методы выявления генетических основ ГБ и подчеркивается важность установления основных этиологических факторов — генетических, эпигенетических и средовых — и их взаимодействия для разработки рациональных методов терапии и профилактики ГБ.

Об авторе

А. Л. Маркель
ФИЦ Институт цитологии и генетики СО РАН; Новосибирский Государственный университет
Россия

Аркадий Львович Маркель — зав. лабораторией эволюционной генетики



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Для цитирования:


Маркель А.Л. ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ: ГЕНЕТИКА, КЛИНИКА, ЭКСПЕРИМЕНТ. Российский кардиологический журнал. 2017;(10):133-139. https://doi.org/10.15829/1560-4071-2017-10-133-139

For citation:


Markel А.L. ESSENTIAL SYSTEMIC HYPERTENSION: GENETICS, CLINICS, EXPERIMENT. Russian Journal of Cardiology. 2017;(10):133-139. (In Russ.) https://doi.org/10.15829/1560-4071-2017-10-133-139

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