ACE INHIBITOR ZOFENOPRIL IN COMPLEX THERAPY OF CHRONIC HEART FAILURE AND DILATED CARDIOMYOPATHY
Abstract
The study assessed the effectiveness of an ACE inhibitor zofenopril in the treatment of patients with dilated cardiomyopathy (DCMP), complicated by chronic heart failure (CHF). The effects of the medication on clinical status, left ventricular (LV) remodelling, systolic and diastolic function were examined. This six-month study included 35 patients (28 men and 7 women; mean age 49 years). The control group, comparable by age and gender distribution, included 30 healthy people. All patients in the main group received zofenopril (7,5-15 mg/d). Clinical status was evaluated by NYCA Functional Class (FC) of CHF, 6-minute walk test results, and the CHF clinical status assessment scale. The analysed echocardiography parameters reflected LV myocardial remodelling, systolic and diastolic function. In 6 months, zofenopril therapy was linked to improved clinical status, quality of life, and LV systolic function, together with reduced CHF symptoms and LV remodelling. Long-term zofenopril therapy resulted in the reversion of restrictive diastolic dysfunction type into non-restrictive in most patients.
About the Authors
Z. T. Astakhova
Северо-Осетинская государственная медицинская академия Росздрава, кафедра госпитальной терапии с курсом ЛФК и спортивной медицины, Владикавказ
Russian Federation
Russian Federation
D. S. Zagalova
Северо-Осетинская государственная медицинская академия Росздрава, кафедра госпитальной терапии с курсом ЛФК и спортивной медицины, Владикавказ
Russian Federation
Russian Federation
References
1. Беленков Ю.Н. Хроническая сердечная недостаточность в России – опыт 25 лет: где мы находимся и куда должны идти?//Сердечная недостаточность. 2003. Т.4. № 1.
2. Беленков Ю.Н., Агеев Ф.Т., Мареев В.Ю. Парадоксы сердечной недостаточности: взгляд на проблему не рубеже веков.// Сердечная недостаточность.–2000. Т. 1. № 2. – С.40–44.
3. Кобалава Ж.Д. Киякбаев Г.К. Зофеноприл. Клинико– фармакологические аспекты. Москва. ООО “Мед- ЭкспертПресс” 2006.
4. Мареев В.Ю. Результаты наиболее интересных исследований по проблеме сердечной недостаточности в 1999 году.// Сердечная недостаточность.– 2000.– Т. 1.– № 1.– С. 8–17.
5. Никитин Н.П., Аляви А.Л. Медикаментозное лечение сердечной недостаточности, вызванной дилатационной кардиомиопатией: влияние на клинический статус, ремоделирование и систолическую функцию левого желудочка.// Кардиология. – 1999. – Т.39. – №5. – С.28-35.
6. Borghi C, Ambrosioni E; Survival of Myocardial Infarction Long– term Evaluation–2 Working Party. Double–blind comparison between zofenopril and lisinopril in patients with acute myocardial infarction: results of the Survival of Myocardial Infarction Long–term Evaluation–2 (SMILE–2) study// Am Heart J. 2003 Jan;145(1):80–87.
7. Buikema H, Monnink SH, Tio RA, et al. Comparison of zofenopril and lisinopril to study the role of the sulfhydryl–group in improvement of endothelial dysfunction with ACE–inhibitors in experimental heart failure// Br J Pharmacol. 2000 Aug;130(8):1999–2007.
8. CONSENSUS Study Group. Effects of enalapril on mortality in severe congestive heart failure – results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)// N Engl J Med 1987; 323:1429-1435.
9. Evangelista S, Manzini S.Antioxidant and cardioprotective properties of the sulphydryl angiotensin–converting enzyme inhibitor zofenopril// J Int Med Res. 2005 Jan– Feb;33(1):42–54.
10. Marzo A, Dal Bo L, Mazzucchelli P, et al. Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers// Arzneimittelforschung. 2002;52(4): 233–42.
11. Nony P., Boissel J., Girard P. et al. Relative efficacy of angiotensin converting enzyme inhibitors on mortality of patients with congestive heart failure: implications of randomized trials and role of the etiology (ischemic or non- ischemic) of heart failure// Eur Heart J 1992; 13: 1101-1108.
12. The SOLVD Investigators. Effects of enalaril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure// N Eng J Med 1991; 325: 293-331.
Review
For citations:
Astakhova Z.T., Zagalova D.S. ACE INHIBITOR ZOFENOPRIL IN COMPLEX THERAPY OF CHRONIC HEART FAILURE AND DILATED CARDIOMYOPATHY. Russian Journal of Cardiology. 2010;(2):74-77. (In Russ.)
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