AFOBAZOLE EFFECTIVENESS IN THE COMPLEX TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION
https://doi.org/10.15829/1560-4071-2014-2-89-95
Abstract
Aim.To study the potential increase in the treatment effectiveness due to accounting for psychological and emotional status features of patients with arterial hypertension (AH). Material and methods. Psychological status features were assessed in 300 patients with essential AH, aged 35 years and older, who attended the Moscow City Polyclinics No. 9. The main group (n=264) was administered antihypertensive therapy and Afobazole (30 mg/d), while the control group (n=36) received only antihypertensive therapy. The number of ambulance calls and the regularity of antihypertensive pharmacological therapy over the last 3 years were assessed. The Spielberger-Khanin and Strelau scales were used for the questionnaire-based assessment of psychological and emotional status. All participants underwent Holter blood pressure (BP) monitoring at baseline and 6 and 18 months after the start of the treatment.
Results. Our variant of antihypertensive therapy was clinically effective and associated with normalised BP parameters, decreased levels of state and trait anxiety, and reduced number of hospital admissions due to the main disease and comorbidities.
Conclusion. Adding Afobazole to the long-term complex treatment of AH patients facilitates stable positive dynamics of BP parameters, normalisation of psychological characteristics, increased duration (up to 6-12 months) of clinical stability periods, and a halved number of hospital readmissions over the following 1,5 years.
About the Authors
E. A. Chumakova
Moscow City Polyclinic No. 9
Russian Federation
Russian Federation
N. I. Gaponova
A.I. Evdokimov Moscow State Medico-Stomatological University
Russian Federation
Russian Federation
T. N. Berezina
Moscow City University of Psychology and Pedagogics, Moscow,
Russia.
Russian Federation
Russian Federation
References
1. Akarachkova ES, Vershinina SV. Vegetative dystonia syndrome or depression? Depressive disorders in somatic practice. Russian Medical Journal 2010, 26 (18):24-6. Russian (Акарачкова Е. С., Вершинина С. В. Синдром вегетативной дистонии или депрессия? Депрессивные расстройств в общесоматической практике. Русский медицинский журнал 2010, 26 (18):24-6).
2. Kobalava ZhD, Kotovskaja JuV. Hypertension: the keys to diagnosis and treatment. Moscow: Izdatel'stvo Fortje Art, 2007. Russian (Кобалава Ж. Д., Котовская Ю.В. Артериальная гипертония: ключи к диагностике и лечению. Москва: Издательство Фортэ Арт, 2007).
3. Smulevich AB, Syrkin AL. Psychocardiology. M. Publisher: Medical Information Agency; 2005. Russian (Смулевич А. Б., Сыркин А. Л. Психокардиология. М.: Издательство: Медицинское информационное агентство; 2005).
4. Berezina TN. Relationship base odors and basic emotions. Questions of psychology. 2012, 4: 106-16 Russian (Березина Т. Н. Взаимосвязь базовых запахов и базовых эмоций Вопросы психологии. 2012, 4: 106-16).
5. Berezina TN. Probabilistic model of longevity. Psychology and Psychotechnique. 2013, 4: 390-400. Russian (Березина Т. Н. Вероятностная модель продолжительности жизни. Психология и психотехника. 2013, 4: 390-400).
6. Boytsov SA, Urinovskij AM, Kuznetsov RL, et al. Structure of the risk factors of target organ damage and metabolic changes in hypertensive patients in different age groups. Kardiologija. 2009, 4: 19-24. Russian (Бойцов С. А., Уриновский А. М., Кузнецов Р. Л. и др. Структура факторов риска, поражений органов-мишеней и метаболических изменений у больных артериальной гипертензией в различных возрастных группах. Кардиология. 2009, 4: 19-24).
7. Glezer MG. Combination therapy with modern treatment strategy in patients with arterial hypertension. Russian Medical Journal. 2008, 16 (11): 1579-86. Russian (Глезер М. Г. Комбинированная терапия современная стратегия лечения паци¬ентов с артериальной гипертонией. Русский медицинский журнал. 2008, 16 (11): 1579-86).
8. Vorob'eva OV. Clinical features of depression in general practice (according to the program COMPAS). Consilium Medicum. 2004, 6: 84-7. Russian (Воробьева О. В. Клинические особенности депрессии в общемедицинской практике (по результатам программы КОМПАС). Consilium Medicum. 2004, 6: 84-7).
9. Romasenko LV. Depression and cardiovascular disease. Neurology, neuropsychiatry, psychosomatika. 2009, 3-4: 8-11. Russian (Ромасенко Л. В. Депрессия и сердечно-сосудистые заболевания Неврология, нейропсихиатрия, психосоматика. 2009, 3-4: 8-11).
10. Ruo B, Rumsfeld JS, Hlatky MA, et al. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA. 2003, 290: 215-21.
11. Pickering TG, Davidson K, Shimbo D. Is depression a risk factor for coronary heart disease? J. Am. Coll. Cardiol. 2004, 44 (2): 472-3.
12. Vasjuk JuA, Dovzhenko TV. Features pathogenetic relationship of depression and cardiovascular disease. Psychiatric disorders in general medicine. 2007, 2 (1): 1-11. Russian (Васюк Ю. А., Довженко Т. В. Особенности патогенетической взаимосвя¬зи депрессии и сердечно-сосудистых заболеваний. Психические расстройства в общей медицине. 2007, 2 (1): 1-11).
13. Shal'nova SA, Balanova JuA, Konstantinov VV, et al. Hypertension prevalence, awareness, antihypertensive drugs and treatment efficacy among the population of the Russian Federation. Russian Journal of Cardiology. 2006, 4: 45-50 Russian (С. А. Шальнова, Ю.А. Баланова, В. В. Константинов и др. Артериальная гипертония: распространен¬ность, осведомленность, прием антигипертензивных препаратов и эффективность лечения среди населения Российской Федерации. Российский кардиологический журнал. 2006, 4: 45-50).
14. Glassman AH. Depression and cardiovascular comorbidity. Dialogues Clin. Neumsci. 2007, 9: 9-17.
Review
For citations:
Chumakova E.A., Gaponova N.I., Berezina T.N. AFOBAZOLE EFFECTIVENESS IN THE COMPLEX TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION. Russian Journal of Cardiology. 2014;(2):89-95. (In Russ.) https://doi.org/10.15829/1560-4071-2014-2-89-95
Views:
1279
Email this article 