BLOOD LIPID AND NON-LIPID BIOMARKERS IN NOVOSIBIRSK MEN WITH CORONARY ATHEROSCLEROSIS
Abstract
Blood lipid (total cholesterol (CH), triglycerides, low and high-density lipoprotein CH (LDL-CH, HDL-CH), lipoprotein (a)) and non-lipid (high-sensitive C-reactive protein (hsCRP), homocysteine, interleukins (IL) beta, 6, and 8, tumor necrosis factor (TNF), metalloproteinase (MP) 3 and 9) were measured in 96 Novosibirsk men, aged 42–70 years, with angiography-confirmed coronary atherosclerosis and Functional Class II-IV stable effort angina, but without acute coronary syndrome. More than 70% of the patients demonstrated an increase in blood levels of total CH, LDL-CH, hsCRP, homocysteine, IL-6, IL-8, and especially MP-9 (elevated in 100% of the men examined).
About the Authors
Yu. I. Ragino
Научно-исследовательский институт терапии СО РАМН
Russian Federation
Russian Federation
A. M. Chernyavsky
ФГУ Новосибирский НИИ патологии кровообращения Росздрава, Новосибирск
Russian Federation
Russian Federation
A. V. Tikhonov
Научно-исследовательский институт терапии СО РАМН
Russian Federation
Russian Federation
S. Yu. Tsymbal
ФГУ Новосибирский НИИ патологии кровообращения Росздрава, Новосибирск
Russian Federation
Russian Federation
Ya. V. Polonskaya
Научно-исследовательский институт терапии СО РАМН
Russian Federation
Russian Federation
E. V. Semaeva
ФГУ Новосибирский НИИ патологии кровообращения Росздрава, Новосибирск
Russian Federation
Russian Federation
M. V. Ivanova
Научно-исследовательский институт терапии СО РАМН
Russian Federation
Russian Federation
M. I. Voevoda
Научно-исследовательский институт терапии СО РАМН
Russian Federation
Russian Federation
References
1. Воевода М.И., Семаева Е.В., Рагино Ю.И. и др. Липидные и липопротеиновые нарушения при коронарном атеросклерозе. Сравнение с популяционными данными // Российский кардиологический журнал, 2005; № 4: 58–63.
2. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации. III пересмотр // Всероссийское научное общество кардиологов, Москва, 2007, 26 с.
3. Рагино Ю.И., Чернявский А.М., Полонская Я.В. и др. Активность воспалительно-деструктивных изменений в процессе формирования нестабильной атеросклеротической бляшки // Кардиология, 2007; 9: 62–67.
4. Adachi T., Naruko T., Itoh A. et al. Neopterin is associated with plaque inflammation and destabilisation in human coronary atherosclerotic lesions // Heart, 2007, 93 (12): 1537–1541.
5. Anderson K.M., Castelli W.P., Levy D. Cholesterol and mortality. 30-year follow-up from the Framingham study // J. Am. Med. Assoc., 1987; V. 257: 2176–2180.
6. Armstrong E.J., Morrow D.A., Sabatine M.S. Inflammatory biomarkers in acute coronary syndromes: part I: introduction and cytokines // Circulation, 2006, 113 (6): e72–75.
7. Armstrong E.J., Morrow D.A., Sabatine M.S. Inflammatory biomarkers in acute coronary syndromes: part IV: matrix metalloproteinases and biomarkers of platelet activation // Circulation, 2006, 113 (9): e382–385.
8. Boekholdt S.M., Peters R.J., Hack C.E. et al. IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study // Arterioscler. Thromb. Vasc. Biol., 2004, 24 (8): 1503–1508.
9. Bucova M., Bernadic M., Buckingham T. C-reactive protein, cytokines and inflammation in cardiovascular diseases // Bratisl. Lek. Listy., 2008, 109 (8): 333–340.
10. Empana J.-P., Canoui-Poitrine F., Luc G. et al. on behalf of the PRIME Study Group. Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study // Eur. Heart J., 2008, 29: 1966–1974.
11. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult treatment panel III) // JAMA, 2001, Vol. 285: 2486–2497.
12. Fruchart J.-C. Pathophysiology of stages of development of atherosclerosis / Handbook of dyslipidemia and atherosclerosis // France, University of Lille, 2003; Part 1, p. 1–65.
13. Koenig W., Khuseyinova N., Baumert J. et al. Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984–2002 // Arterioscler. Thromb. Vasc. Biol., 2006, 26 (12): 2745–2751.
14. Kronenberg F., Kronenberg M.F., Kiechl S. et al. Role of lipoprotein (a) and apolipoprotein (a) in atherogenesis: prospective results from the Bruneck study //Circulation, 1999; 100: 1154–1161.
15. Pearson T.A., Mensah G.A., Alexander R.W. et al. Centers for Disease Control and Prevention; American Heart Association. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association // Circulation, 2003, 107 (3): 499–511.
16. Sukhija R., Fahdi I., Garza L. et al. Inflammatory markers, angiographic severity of coronary artery disease, and patient outcome // Am. J. Cardiol., 2007, 99 (7): 879–884.
17. Wald D.S., Law M.R., Wald N.J. and Morris J.K. Serum homocystein and coronary heart disease. Coronary heart epidemiology // Oxford: University press, 2005; V. 16: 239–250.
18. White A.J., Duffy S.J., Walton A.S. et al. Matrix metalloproteinase-3 and coronary remodeling: implications for unstable coronary disease // Cardiovasc. Res., 2007, 75 (4): 813–820.
Review
For citations:
Ragino Yu.I., Chernyavsky A.M., Tikhonov A.V., Tsymbal S.Yu., Polonskaya Ya.V., Semaeva E.V., Ivanova M.V., Voevoda M.I. BLOOD LIPID AND NON-LIPID BIOMARKERS IN NOVOSIBIRSK MEN WITH CORONARY ATHEROSCLEROSIS. Russian Journal of Cardiology. 2009;(2):31-35. (In Russ.)
Views:
439
Email this article 