LIPID PROFILE AND CALCIUM AND PHOSPHATE METABOLISM IN PATIENTS WITH CORONARY HEART DISEASE AND AORTIC STENOSIS
Abstract
Aim. To compare the parameters of lipid profile and calcium and phosphate metabolism in patients with coronary heart disease (CHD) or CHD combined with aortic stenosis (AS). Material and methods. The study included 147 CHD patients, aged over 60, with stable angina pectoris, (functional Class (FC) I–IV) and degenerative calcific AS. The comparison group included 41 CHD patients without calcification or stenosis of aortal valve. In all participants, the parameters of lipid profile and calcium and phosphate metabolism were assessed. Results. Dyslipidemia was more prevalent in CHD patients without AS (85,4% vs. 68%). AS was linked to lower levels of total cholesterol and triglycerides. However, the combination of AS and mitral calcification was characterised by higher levels of low-density and non-high-density lipoprotein cholesterol (LDL–CH and non-HDL–CH). More severe AS was associated with decreased levels of non-HDL–CH and elevated levels of parathyroid hormone, ionized calcium, and alkaline phosphatase. There was a direct correlation between the levels of parathyroid hormone and the presence of calcific AS (r=0,532; p=0,013). Conclusion. The results obtained confirm the disturbance of lipid and calcium metabolism among patients with calcific AS, which suggests that this cardiac valve pathology could be regarded as a manifestation of ectopic calcinosis.
About the Authors
O. A. Rodicheva
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
S. Yu. Levashov
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
E. G. Volkova
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
References
1. Iung B., Gohlke-Barwolf C., Tornos P. Et al. Recommendations on the management of the asymptomatic patient with valvular heart disease. ESC working group report. Eur Heart J 2002; 23 (16):1253–66.
2. Andropova O. V. Forecasting of formation and progressing of degenerative aortic stenosis on risk factors. Avtoref. M 2005, p. 31. Russian (Андропова О. В. Прогнозирование формирования и прогрессирования дегенеративного аортального стеноза по факторам риска. Автореф. дис. к. м.н. М. 2005, с. 31).
3. Karpova N. Y. The calcific aortic stenosis in clinic of internal diseases – interrelation with a system calcium and bone metabolism. Dis. MD. M 2007, р. 50. Russian (Карпова Н. Ю. Кальцинированный аортальный стеноз в клинике внутренних болезней – взаимосвязь с системным обменом кальция и костным метаболизмом. Дис. д. м.н. Москва 2007. с. 50).
4. Pohle K., Maffert R., Ropers D. Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors. Circulation 2001; 87:807–9.
5. Milovanova L. Ju., Milovanov S. Ju., Kozlovsky L. V. Disoders of mineral metabolism in chronic renal disease stages III–IV. Clinical nephrology 2011; 1: 58–67. Russian (Милованова Л. Ю., Милованов С. Ю., Козловская Л. В. Нарушения фосфорно-кальциевого обмена при хронической болезни почек III–IV стадий. Клиническая нефрология 2011; 1: 58–67).
6. Elisa Poggianti R. N., Lucia Venneri M. D. et al. Aortic Valve Sclerosis Is Associated With Systemic Endothelial Dysfunction. J Am Coll Cardiol 2003; 41:136–41.
7. Ortlepp J. R., Schmitz F., Bozoglu T. et al. Cardiovascular risk factors in patients with aortic stenosis predict prevalence of coronary artery disease but not of aortic stenosis: an angiographic pair matched case–control study. Heart 2003; 89:1019–22.
8. Boon A., Cheriex E., Lodder J. et al. Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart. 1997; 78:472–4.
9. Matthew A., Allison M. A., Cheung P., et al. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 2006; 113:861–6.
10. Linhartova K., Veselka J. Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. Circulation 2008; 72 (2):245–50.
11. Akat K., Kaden JJ., Ortlepp JR. et al. Calcium metabolism in adults with severe aortic valve stenosis and preserved renal function. Am J Cardiol 2010; 15; 105 (6):862–4.
12. Milovanova L. Yu., Nikolaev A. Yu., Milovanov Yu. S. Hyperphosphataemia as a risk factor of cardiovascular diseases in chronic hemodialysis patients. Nephrology and dialysis. 2002; 2 (4):113–7. Russian (Милованова Л. Ю., Николаев А. Ю., Милованов Ю. С. Гиперфосфатемия как фактор риска сердечно-сосудистых заболеваний у больных ХПН на хроническом гемодиализе. Нефрология и диализ. 2002; 2 (4):113–7).
Review
For citations:
Rodicheva O.A., Levashov S.Yu., Volkova E.G. LIPID PROFILE AND CALCIUM AND PHOSPHATE METABOLISM IN PATIENTS WITH CORONARY HEART DISEASE AND AORTIC STENOSIS. Russian Journal of Cardiology. 2012;(6):55-59. (In Russ.)
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