CENTRAL HEMODYNAMICS IN ELDERLY PATIENTS WITH CHRONIC HEART FAILURE: THE EFFECTS OF COMPLEX TREATMENT INCLUDING PERINDOPRIL/INDAPAMIDE AND LOW-INTENSITY LASER THERAPY

Aim. To assess and compare the effects of perindopril/indapamide (Noliprel) and low-intensity laser therapy (LILT) on central hemodynamic parameters in elderly patients with chronic heart failure (CHF). Material and methods. In total, 160 CHF patients, aged 60–96 years, were randomised into four groups. Group 1, “Noliprel” (n=26), received Noliprel and other medications; Group 2, “LILT” (n=54), received LILT and other medications (not Noliprel); Group 3, “Noliprel + LILT” (n=27), was administered complex treatment with LILT and Noliprel; and Group 4, a comparison group (n=53), received pharmacological therapy only. At baseline and 20 days after the start of the treatment, central hemodynamic parameters were assessed, using Doppler echocardiography method. Results. At baseline, our participants typically had normal systolic function, in combination with diastolic dysfunction and increased heart chamber size. By the end of the treatment phase, reverse cardiac remodelling was observed in Noliprelreceiving patients. In the “LILT” group, myocardial function improvement was not accompanied by marked morphological changes. The combination of Noliprel and LILT had a complementary beneficial effect on intracardiac hemodynamics, particularly in Functional Class III CHF. Conclusion. In elderly CHF patients, including Noliprel and LILT into the complex CHF treatment demonstrated a larger positive effect on central hemodynamics, compared to the standard treatment.

chronic heart failure, elderly age, central hemodynamics, Noliprel, lowintensity laser therapy

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