ROENTGEN-STRUCTURAL AND ROENTGEN-SPECTRAL ANALYSIS OF SERUM FACIES IN CARDIOVASCULAR DISEASE DIAGNOSTICS

In patients with various clinical forms of coronary heart disease (CHD), essential arterial hypertension (EAH), or chronic heart failure (CHFD), roentgen-structural and roentgen-spectral analysis of serum facies was performed. In total, 159 patients were examined (mean age 57,2±6,08 years). All participants were divided into six groups: Group I – with Functional Class (FC) III effort angina (n=19); Group II – with healing myocardial infarction, MI (n=10); Group III – with paroxysmal recurrent atrial fibrillation, PRAF (n=19); Group IV – with Stage II EAH (n=34); Group V – with FC III–IV ischemic CHF (n=17); and Group VI – relatively healthy people (n=30). Microphotography of the serum facies was performed using electronic microscopy (S-3400N); energy-dispersive spectral analysis of the facies was also performed. Increased peripheral zone with spherical crystals, together with globular formations and decalcination in the centre was linked to the diagnosis of stable angina. Peripheral zone decrystallization, increased central zone with rosette-like crystals, and weight percentage of phosphorus >0,5% was observed in MI patients. No obvious zone separation, increased number of radial fissures, migration of crystal mass from central to peripheral area, and weight percentages of carbon, magnesium, and calcium in the central area of >10%, <0,01%, and <0,4%, respectively, were registered in EAH. PRAF was characterised by several crystallization centres in the central zone, absence of calcium, and weight percentage of phosphorus of 0,6±0,12 in the centre. CHF patients demonstrated total crystallization of the centre, singular peripheral crystals, and maximal weight percentage of carbon in the peripheral zone (72,0±0,43%), with phosphorus and calcium identified, respectively, in the central zone only and both central and peripheral zones. Atherosclerosis and associated clinical conditions are among the diseases with an important pathogenetic role of crystallization.

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